DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncoa6 and Ncoa6

DIOPT Version :9

Sequence 1:	NP_001097088.3	Gene:	Ncoa6 / 33761	FlyBaseID:	FBgn0031698	Length:	2467	Species:	Drosophila melanogaster
Sequence 2:	NP_062799.2	Gene:	Ncoa6 / 56406	MGIID:	1929915	Length:	2069	Species:	Mus musculus

Alignment Length:	2580	Identity:	565/2580 - (21%)
Similarity:	826/2580 - (32%)	Gaps:	940/2580 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQLEP-SLVRILVSLPWDAAQRLRQLANDGNPELRALNIQSVQFEGDSVINLKVG---GQDIKIT 65
            |::|| :.||:..::|.:||:|||.||...|.:||.|.|.|||.||:..|||.:|   .||:::.
Mouse    86 QKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALGQNRSQDVRMN 150

  Fly    66 KDNVNETLEAAGSLSGNKSGLLATGF---DGPS----TSKAA----------SAFMQQQQQRILQ 113
                       |.::...|..:..||   .||.    ||.||          |:.|.......||
Mouse   151 -----------GPVASGNSVRMEAGFPMASGPGLIRMTSPAAVMTPQGGNMSSSMMAPGPNPELQ 204

  Fly   114 ----QP--QNDA-------ISLQQRRAAAAGL-----GLQKMP------------LHTTQQQQQQ 148
                :|  |:||       :.:||:...:..|     .:|.:|            |...||||||
Mouse   205 PRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLPPAHHSMQPVPVNRQMNPANFPQLQQQQQQQQQ 269

  Fly   149 QQQQQVAVTPAVFKSPNTVCPMEGKVPLLLPSPSATRDFPFESMRQARVLQGREAGGLGPPLPPP 213
            |||||                          .....:....:..:|.:.||.|       ||
Mouse   270 QQQQQ--------------------------QQQQQQQQQQQQQQQQQQLQTR-------PL--- 298

  Fly   214 PPPNVTLKVLKTQQQQAPQNGELTPTTPTSAAPTPPG---SKSQFIQPPPPPYPGLGAATASS-- 273
                       .|.||.||......|.||. .|.|||   ..|..:| |||....||..|.:.
Mouse   299 -----------QQHQQQPQGIRPQFTAPTQ-VPVPPGWNQLPSGALQ-PPPAQGSLGTMTTNQGW 350

  Fly   274 ----VSSPIAIAGVSAKPAIVTAPSQLNHPLGHPPLPTATSTGSNNIAISSPLLVNLLQNDGNGM 334
                :.||:. |.:.|:|::.|..:. :||  .||.|    .||..   :|....|..|     |
Mouse   351 KKAPLPSPMQ-AQLQARPSLATVQTP-SHP--PPPYP----FGSQQ---ASQAHTNFPQ-----M 399

  Fly   335 SNPNQLKSPQQQQQQSPLIGMSPSGAQMMNSPMRSSGPA-TPSDFLMGDVLSPVVPSSPTTPQAA 398
            |||.|..:||.:..|.   |.|.....:....:.:..|| :||.|..|   ||.  ||||..|.
Mouse   400 SNPGQFTAPQMKGLQG---GPSRVPTPLQQPHLTNKSPASSPSSFQQG---SPA--SSPTVNQT- 455

  Fly   399 APPCPPPVVMRNLQQQQQQHQQAMLSPSGNANHLYTQQQQQGPQQQQPQQQQQGPPHRFQQQHQQ 463
                                                 |||.||:..|.....||    |||
Mouse   456 -------------------------------------QQQMGPRPPQNNPLSQG----FQQ---- 475

  Fly   464 MSPQAVALRQQQLQRQQQMRFMQPQQQLQGQQQPQQQFQPAPDCFNNMGMGPMQQQQIRHQLRP- 527
              |.:...|...:|:..     .|...:..||||..|             ||       ..|.|
Mouse   476 --PVSSPGRNPMVQQGN-----VPPNFMVMQQQPPNQ-------------GP-------QSLHPG 513

  Fly   528 -GGLPLAPPPPHPQQQQQQRLMGLSMPQASPQQQFMSGASPLGPALSPASSHHSMHSPLMSNHQA 591
             ||:|...||            |.|..||:|  .||.|..|...|.:|            .|..|
Mouse   514 LGGMPKRLPP------------GFSAGQANP--NFMQGQVPSTTAATP------------GNSGA 552

  Fly   592 QQQQQPQMVSPAATPGPTAPSEMAGQLMPANQHVPAAPPPDYNQAAVNSRWPLAGINKPMDSATK 656
            .|.|..|.|..|...|       ||.  |.||...:..||:..|.:      |.||:..:::
Mouse   553 LQLQANQNVQHAGGQG-------AGP--PQNQMQVSHGPPNMMQPS------LMGIHGNINN--- 599

  Fly   657 SSFQEFTRYQMQYNLQQQQQQVSLPGQPQ----QQQQQPQQQQLPPPALPTQQQQQQQSHVQQPQ 717
                               ||....|.||    ..|.||||.  ||..|....||...|   |.|
Mouse   600 -------------------QQAGSSGVPQVTLGNMQGQPQQG--PPSQLMGMHQQIVPS---QGQ 640

  Fly   718 VAGQTQGQVDSLISLSVLDTLTTNDLDALLPTLNCDLDSTLSLEDKNELESLLQDAKDLDLDLIE 782
            :| |.||                        |||          .:|.:
Mouse   641 MA-QQQG------------------------TLN----------PQNPM---------------- 654

  Fly   783 DNLSAVDMRDALNTLQEAPLEQQQQQ----QQQQAAMQPQQQTAQMMQMPYQQQPQQQQQMQQQL 843
                         .|..|.|..|.|.    |.|.....||:.|.....:| ||.||......|.:
Mouse   655 -------------ILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLP-QQGPQMMAPHNQMM 705

  Fly   844 MMQQQQRQQQLPQMQQ---RQQQHLQRQLQLQQQQ----------------------QQQQQQQL 883
            ..|.|...||.|.::|   .|.|..:.|...|.|.                      |...|...
Mouse   706 GPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSG 770

  Fly   884 QIVQRQQQQQQSQLQVQHPQ-QPQRPPQKQFIINPHTGDMEPMASDDSETEAEEETAQPQFRNSH 947
            |::.:|.....|..||...| |..|||..    :||.....    :|..|.|.
Mouse   771 QMLPQQGPVNNSPSQVMGIQGQVLRPPGP----SPHMAQQH----NDPVTTAN------------ 815

  Fly   948 SGLGSFNFNPANDMLLPTNLFSEEDSNSAQQHPMGISSDQERSRDSLASNKSATSRARKTPVSKA 1012
                       ||:.| :.:..:.....|...|..:.|.|..|  :..|:.|....:...|...|
Mouse   816 -----------NDVNL-SQMMPDVSMQQASMVPPHVQSMQGNS--ASGSHFSGHGVSFNAPFGGA 866

  Fly  1013 -NHSNFSAGDNSPRSSN-----SSPLI-------------GLNSPQSVNANAGGAPSKKAKPNLL 1058
             |.|..|.|.|.....|     :|||:             |:|:.|: |.|| ..|.||..|
Mouse   867 PNGSQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQN-NTNA-NKPKKKKPP--- 926

  Fly  1059 RGKLQQGVKERKAKD-----------PTAAPKQKRERAKGNVKTKAAEEKIKLRLKLEKVETTPA 1112
                      ||.|:           ||...:..::...|       |:.|.|.....|:.....
Mouse   927 ----------RKKKNCHQDLNTPDNRPTGLEEVDQQSLPG-------EQGINLDTTGPKLPDFSN 974

  Fly  1113 AGAGYEGQIIINQQQQQTIVVNNHMQQLPMQ-TQLLALPTQQQQQQQQQQQQQQQQMQQPQMQIS 1176
            ...||..|.:    :|:.      :.|:|.| .|.:|.|.|..|||.|.|..||||...|....|
Mouse   975 RPPGYPTQPV----EQRP------LPQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQS 1029

  Fly  1177 QQQHQQQQQTSQL--QQQP--AQLQQQQPQQQQQQPIQQQQQHHPVYSNFQQQQQQQQQQQQNVP 1237
            |||.||||....|  ||.|  .:|...|.....:.|:....|..||            ||..|||
Mouse  1030 QQQQQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRMPV------------QQSGNVP 1082

  Fly  1238 ------GPNEPRVPPLQIRLRGKNHVVVKNTRKDRKKGQNQEASIDERQLKRSYSDQPPQQLLMD 1296
                  ||  ..|||...:.|....|   ||    ..|.|..        |..|.:.|
Mouse  1083 VMVGLQGP--ASVPPSPDKQRMPMSV---NT----PMGSNSR--------KMVYQENP------- 1123

  Fly  1297 PAESKQAKLTPPPHVNGLPILIQKTTATVASPQLPQQLQGGVATTTKTTTIVAGKNGLTISAIVE 1361
                :.:..:|...::.||                      .|:.::..::..|.|.:....:|.
Mouse  1124 ----QNSSSSPLGEMSSLP----------------------EASGSEVPSVAGGPNNMPSHLVVS 1162

  Fly  1362 AHKAQAQAQAQSLNDPQLIVGSTNTGTTPTSTTLQQQQLSKIATSLPSSITLSAINSNNNNNNVN 1426
            .:              ||::.....|.:|.|.|...........|||||
Mouse  1163 QN--------------QLMMTGPKPGPSPLSATQGATPQQPPVNSLPSS---------------- 1197

  Fly  1427 SGNNNNRLLTMKNPIKTAATITPIVGGK----PMTKNHKPPPYITAVQQLQLQKQQQQQQQQQQQ 1487
               :.:....:..|.:|:...||.....    |.|.|::||.  |...::.|
Mouse  1198 ---HGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPS--TEPSEISL------------- 1244

  Fly  1488 QQQQQQQQQQRQLAAAVTMLPSATTLKRVEITKVTPQVTAEQAP-----------SINPSPVVVA 1541
                   ..:|..|:...:.|              ||:.....|           .:||:.:...
Mouse  1245 -------SPERLNASIAGLFP--------------PQINIPLPPRPNLNRGFDQQGLNPTTLKAI 1288

  Fly  1542 AAATATLTTSSTPTTQTTQLICDRKLPVAMPPMTTVNNVVVATVNSSSAALSTLSSVSTASSASI 1606
            ..|.:.||.::.|.             .|.|....:::|||.:...|:..
Mouse  1289 GQAPSNLTITNPPN-------------FAAPQAHKLDSVVVNSGKQSNPG--------------- 1325

  Fly  1607 ITTSTSTSSPAALPSTLRNSPASNGSGTPGHGNNGGGEDSGIESMDALSEKSPHQLSSSSP--IQ 1669
               :|..:||:   ::.|:||.|:...||                      ||.:.:|.:|  ..
Mouse  1326 ---TTKRASPS---NSRRSSPGSSRKTTP----------------------SPGRQNSKAPKLTL 1362

  Fly  1670 VSKAAVTMVQQQQQQTNAIVTITTSAAVIAPVIAPTSTQAGTTPTVAPSLQQQQKQQADDEIEKA 1734
            .|:.:.||:|..:...|.:|                    |.||...|.|
Mouse  1363 ASQTSTTMLQNMELPRNVLV--------------------GPTPLANPPL--------------- 1392

  Fly  1735 LAKMEGDFPDD------------------LEDIVSSM-IKETSECASAAG-GGFLNSLESSLPA- 1778
                .|.||::                  |||...|: |.:.|:|.:|.| ...:|:....:|.
Mouse  1393 ----PGSFPNNTGLNPQNPTVPVPAMGTVLEDNKESVNIPQDSDCQNAQGRKEQVNTELKVVPTQ 1453

  Fly  1779 -ATVATVVSTASTNTSSIGSIKLNGEHHILEHDDLIKKLTESKPPAIKVKLEEM-PPLLTIKKE- 1840
             |.:|.....:..:...:...||..   :.|:.:|:.......|.::...|:.. .|.:|||..
Mouse  1454 EAKMAVPEDQSKKDGQPLDPNKLPS---VEENKNLMSPAMREAPTSLSQLLDNSGAPNVTIKPPG 1515

  Fly  1841 ----PVIKPMASGLKVEAKVEVKLEPKVEPKSEEKLQEKPPSESSSASL------QPISI----- 1890
                .|..|:.||       |...:..|.|..::     |||:..|.||      :|.|.
Mouse  1516 LTDLEVTPPVVSG-------EDLRKASVIPTLQD-----PPSKEPSTSLSSPHSSEPCSTLARSE 1568

  Fly  1891 --EIPAQVDGETPRIRTR--ASSRLESPLDAQKASPDPTTVTGVSTTAATAANAS---------- 1941
              |:.:......|.:.:|  :||.:.:||     .|:..||...|....|::|.|
Mouse  1569 LSEVSSNTAPSIPPVMSRPVSSSSISTPL-----PPNQITVFVTSNPITTSSNTSAALPTHLQSA 1628

  Fly  1942 --TTVKSL-------------SRASSTASPRVVTPTPNHNNNNNKRRRQESECGSSNDGADLGEN 1991
              :||.::             |.|.|.|.|:.:||.  ..|:::..:..:....|:.....|..|
Mouse  1629 LMSTVVTMPNVGNKVMVSEGQSAAQSNARPQFITPV--FINSSSIIQVMKGSQPSTIPATPLTTN 1691

  Fly  1992 SIKRP---------------RISSGTTSNNNATETAAEHNAGAGLP-------KKVEIESSD-SD 2033
            |...|               :.||...:.|..:.:.|. |...|.|       ..|::.|.. :.
Mouse  1692 SGLMPPSVAVVGPLHIPQNIKFSSAPVTPNVPSSSPAP-NIQTGRPLVLSSRATPVQLPSPPCTS 1755

  Fly  2034 EPLIEVAGKVRNSKQAQVEAADAAAVGVEKHVTRRNAQQ--LQPPQNKTA---------GNHAPS 2087
            .|::.....|:..|:...:.|...        |..:|.|  |.|.|..|.         |:.|..
Mouse  1756 SPVVAPNPSVQQVKELNPDEASPQ--------TNTSADQSTLPPSQPTTVVSPLLTNSPGSSANR 1812

  Fly  2088 STPALGTPRSG----------------------KAQAPVGA------------------TSAANN 2112
            .:|...:...|                      |.:...||                  |...:.
Mouse  1813 RSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGPGLEITTPGLMGTEQCST 1877

  Fly  2113 NHNSST----------ANNASVVPSSVTT-TTMPGGAVVTTSQVNSGTSVVHATRGATAAAASTT 2166
            ..:|.|          ..::.:.|||.:| ..:|||| :.||..:..|::|.:...:||......
Mouse  1878 ELDSKTPTPSAPTLLKMTSSPMGPSSTSTGPILPGGA-LPTSVRSIVTTLVPSELISTAPTTKGN 1941

  Fly  2167 NNNSASSP-----TDEKIGTRRSVRASAAANKIIYSRSNAAAAAAAAAAAAEPKGTTGKAGAAVG 2226
            :....|.|     .:||:|:...:..|.|.::.:..:...|.|...:.|..|.     :|.||:.
Mouse  1942 HGGVTSEPLAGGLVEEKVGSHPELLPSIAPSQNLAPKETPATALQGSVARPEL-----EANAAIA 2001

  Fly  2227 ANNAGNVESVAE------ARR--KTRSAVIGESMLTEGRRRRTSR 2263
            :..:...:.:.|      :||  :|....:....:..|.|:|:||
Mouse  2002 SGQSCEPKEIVEKSKTLTSRRNSRTEEPTMASESVENGHRKRSSR 2046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncoa6	NP_001097088.3	Nucleic_acid_bd	<12..>64	CDD:290532	26/54 (48%)
Ncoa6	NP_062799.2	Nucleic_acid_bd	48..189	CDD:372737	41/123 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..253		26/111 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..550		71/264 (27%)
		Med15	471..>864	CDD:312941	90/398 (23%)
		NCOA6IP-binding region. /evidence=ECO:0000250	779..933		33/157 (21%)
		LXXLL motif 1	893..897		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..1281		109/436 (25%)
		KAR9	<1082..1326	CDD:369971	77/284 (27%)
		PHA03247	<1173..1810	CDD:223021	133/664 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1315..1360		14/50 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1426..1483		9/56 (16%)
		LXXLL motif 2	1497..1501		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1499..1583		12/87 (14%)
		EP300/CRSP3-binding region. /evidence=ECO:0000250	1646..2069		96/492 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1771..1824		6/52 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1842..1913		12/74 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1959..2069		31/149 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28IB7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4616
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008009
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4925
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.980