Protein Alignment Ncoa6 and Ncoa6

DIOPT Version :10

• Sequence 1: NP_001097088.3
• Gene: Ncoa6 / 33761
• FlyBaseID: FBgn0031698
• Length: 2467
• Species: Drosophila melanogaster
• Sequence 2: NP_001263643.1
• Gene: Ncoa6 / 116464
• RGDID: 620111
• Length: 2058
• Species: Rattus norvegicus
• Alignment Length: 2577
• Identity: 547/2577 - (21%)
• Similarity: 822/2577 - (31%)
• Gaps: 945/2577 - (36%)

  Fly     5 QQLEP-SLVRILVSLPWDAAQRLRQLANDGNPELRALNIQSVQFEGDSVINLKVG---GQDIKIT 65
            |::|| :.||:..::|.:||:|||.||...|.:||.|.|.|||.||:..|||.:|   .||:::.
  Rat    86 QKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALGQNRSQDVRMN 150

  Fly    66 KDNV--NETLEAAGSLSGNKSGLLATGFDGPST------SKAASAFMQQQQQRILQ----QP--Q 116
            ...|  |.....||....:..||:.  ...|:|      ..|:|:.|.......||    :|  |
  Rat   151 GPVVSGNSVRMEAGFPMASGPGLIR--MTSPATVMMPQGGNASSSMMAPGPNPELQPRTPRPASQ 213

  Fly   117 NDA-------ISLQQRRAAAAGL-----GLQKMPLH-----------TTQQQQQQQQQQQVAVTP 158
            :||       :.:||:...:..|     .:|.:|::           ..|||||||||||
  Rat   214 SDAMDPLLSGLHIQQQSHPSGSLPPAHHPMQPVPVNRQMNPANFPQLQQQQQQQQQQQQQ----- 273

  Fly   159 AVFKSPNTVCPMEGKVPLLLPSPSATRDFPFESMRQARVLQGREAGGLGPPLPPPPPPNVTLKVL 223
                                           :..:|.:.||.|.                    |
  Rat   274 -------------------------------QQQQQQQQLQTRP--------------------L 287

  Fly   224 KTQQQQAPQNGELTPTTPTSAAPTPPG---SKSQFIQPPPPPYPGLGAATASS------VSSPIA 279
            :..|||.||......|.||. .|.|||   ..|..:| |||....||..|.:.      :.||:.
  Rat   288 QQHQQQQPQGIRPQFTAPTQ-VPVPPGWNQLPSGALQ-PPPAQGSLGPMTTNQGWKKAPLPSPMQ 350

  Fly   280 IAGVSAKPAIVTAPSQLNHPLGHPPLPTATSTGSNNIAISSPLLVNLLQNDGNGMSNPNQLKSPQ 344
             |.:.|:|::.|..:. :||  .||.|    .||..   :|....|..|     ||||.|..:||
  Rat   351 -AQLQARPSLATVQTP-SHP--PPPYP----FGSQQ---ASQAHTNFPQ-----MSNPGQFTAPQ 399

  Fly   345 QQQQQSPLIGMSPSGAQMMNSPMRSSGPA-TPSDFLMGDVLSPVVPSSPTTPQAAAPPCPPPVVM 408
            .:..|.   |.|.....:....:.:..|| :||.|..|   ||.  ||||..|.
  Rat   400 MKSLQG---GPSRVPTPLQQPHLTNKSPASSPSSFQQG---SPA--SSPTVNQT----------- 445

  Fly   409 RNLQQQQQQHQQAMLSPSGNANHLYTQQQQQGPQQQQPQQQQQGPPHRFQQQHQQMSPQAVALRQ 473
                                       |||.||:..|.....||    |||      |.:...|.
  Rat   446 ---------------------------QQQMGPRPPQNNPLSQG----FQQ------PVSSPGRN 473

  Fly   474 QQLQRQQQMRFMQPQQQLQGQQQPQQQFQPAPDCFNNMGMGPMQQQQIRHQLRP--GGLPLAPPP 536
            ..:|:..     .|...:..||||..|..|:                    |.|  ||:|...||
  Rat   474 PMVQQGN-----VPPNFMVMQQQPPSQGPPS--------------------LHPGLGGMPKRLPP 513

  Fly   537 PHPQQQQQQRLMGLSMPQASPQQQFMSGASPLGPALSPASSHHSMHSPLMSNHQAQQQQQPQMVS 601
                        |.|..||:|  .||.|..|...|.:|            .|..|.|.|..|.|.
  Rat   514 ------------GFSAGQANP--NFMQGQVPSTTAATP------------GNSGALQLQANQSVQ 552

  Fly   602 PAATPGPTAPSEMAGQLMPANQHVPAAPPPDYNQAAVNSRWPLAGINKPMDSATKSSFQEFTRYQ 666
            .|...|       ||.  |.||...:..||:..|.:      |.||:..:::
  Rat   553 HAGGQG-------AGP--PQNQMQVSHGPPNMMQPS------LMGIHGNINN------------- 589

  Fly   667 MQYNLQQQQQQVSLPGQPQ----QQQQQPQQQQLPPPALPTQQQQQQQSHVQQPQVAGQTQGQVD 727
                     ||....|.||    ..|.||||.  ||..|....||
  Rat   590 ---------QQAGSSGVPQVTLGSMQGQPQQG--PPSQLMGMHQQ-------------------- 623

  Fly   728 SLISLSVLDTLTTNDLDALLPTLNCDLDSTLSLEDKNELESLLQDAKDLDLDLIEDNLSAVDMRD 792
                              ::|:
  Rat   624 ------------------IVPS------------------------------------------- 627

  Fly   793 ALNTLQEAPLEQQQQQQQQQAAMQPQQ----QTAQMM---QMPYQQQPQQQQQMQQQLMMQQQQR 850
                        |.|..|||..:.||.    ..||:|   ||....|.|......|::...:|..
  Rat   628 ------------QGQMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQML 680

  Fly   851 QQQLPQMQQRQQQHL--QRQLQLQQQQQQQQQQQLQIVQRQQQQQQSQLQVQH-------PQQPQ 906
            .||.|||.....|.:  |.|:.|||....:     ||:..|.|..::|...|:       |.|..
  Rat   681 PQQGPQMMAPHNQMMGPQGQVLLQQNPMIE-----QIMTNQMQGNKAQFNSQNQSNVMPGPAQIM 740

  Fly   907 R--PPQKQFIINPHTGDME--------PMASDDSETEA-EEETAQPQFRNSHSGLGSFNFNPAND 960
            |  .|..|..:...||.|.        |:::..|:... :.:..:|...:.|  :...:.:||..
  Rat   741 RGPTPNMQGNMVQFTGQMSGQMLPQQGPVSNSPSQVMGIQGQVLRPPGPSPH--MAQQHTDPATT 803

  Fly   961 MLLPTNLFSEEDSNSAQQH---PMGISSDQERSRDSLASNKSATSRARKTPVSKA-NHSNFSAGD 1021
            .....||.......|.||.   |..:.|.|..|  :..|:.|....:...|...| |.:..|.|.
  Rat   804 ANNDVNLSQMMPDVSMQQTSMVPPHVQSMQGNS--ASGSHFSGHGVSFNAPFGGAPNGTQMSCGQ 866

  Fly  1022 NSPRSSNSSPLIGLNSPQSVNANAGGAPSKKAKPNLLRGKLQQ---GVKERKAKDPTAAPKQKRE 1083
            |.....|..  :.|.||..|              |||:..:..   ||..:  ::.|.|.|||
  Rat   867 NPGFPVNKD--VTLTSPLLV--------------NLLQSDISAGHFGVNNK--QNNTNANKQK-- 911

  Fly  1084 RAKGNVKTKAAEEKIKLRLKLEKVETTPAAGAGYEGQIIINQQQ---QQTIVVNNHMQQLP-MQT 1144
                  |.|...:|......|...::.|   ||.|.   ::||.   :|.|.::|...:|| ...
  Rat   912 ------KKKPPRKKKNCHQDLNTPDSRP---AGLEE---VDQQSLPGEQGINLDNTGPKLPDFSN 964

  Fly  1145 QLLALPTQQQQQQQQQQQ----------QQQQQMQQPQMQISQQQHQQQQQTSQLQQQPAQLQQQ 1199
            :....|||..:|:..||.          ..|...||||.|:.|||.|.|      ...|:|.|.|
  Rat   965 RPPGYPTQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQPQPQ------PPPPSQPQSQ 1023

  Fly  1200 QPQQQQQQPIQQQQQ----HHPVYSNFQQQQQQQQQQQQNVPGPNEPRVPPLQIRLRGKNHVVVK 1260
            |.|||....:..||.    ..||..|....:.......|.||......| |:.:.|:|
  Rat  1024 QQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRVPMQQSGNV-PVMVSLQG------- 1080

  Fly  1261 NTRKDRKKGQNQEASIDERQLKRSYSDQPPQQLLMDPAESKQAKLTP---PPHVNGLPILIQKTT 1322
                        .||:                   .|:..||....|   |...|...::.|::.
  Rat  1081 ------------PASV-------------------PPSPDKQRMPMPVNTPLGSNSRKMVYQESP 1114

  Fly  1323 ATVASP--QLPQQLQGGVATTTKTTTIVAGKNGLTISAIVEAHKAQAQAQAQSLNDPQLIVGSTN 1385
            ...:||  ::|...:.|   .::..::..|.:.:....:|..:              ||::....
  Rat  1115 QNSSSPLGEMPSLPEAG---GSEVPSVSGGPSNMPSHLVVSQN--------------QLMMTGPK 1162

  Fly  1386 TGTTPTSTTLQQQQLSKIATSLPSSITLSAINSNNNNNNVNSGNNNNRLLTMKNPIKTAATITPI 1450
            .|.:|.|.|...........|||||                   :.:....:..|.:|:...||.
  Rat  1163 PGPSPLSATQGATPQQPPVNSLPSS-------------------HGHHFPNVAAPTQTSRPKTPN 1208

  Fly  1451 VGGK----PMTKNHKPPPYITAVQQLQLQKQQQQQQQQQQQQQQQQQQQQQRQLAAAVTMLPSAT 1511
            ....    |.|.|::||.  |...::.|                    ..:|..|:...:.|
  Rat  1209 RASPRPYYPQTPNNRPPS--TEPSEISL--------------------SPERLNASIAGLFP--- 1248

  Fly  1512 TLKRVEITKVTPQVTAEQAP-----------SINPSPVVVAAAATATLTTSSTPTTQTTQLICDR 1565
                       ||:.....|           .:||:.:.....|.:.||.|:.|.
  Rat  1249 -----------PQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTVSNPPN---------- 1292

  Fly  1566 KLPVAMPPMTTVNNVVVATVNSSSAALSTLSSVSTASSASIITTSTSTSSPAALPSTLRNSPASN 1630
               .|.|....:::|||::...|:..                  :|..:||:   ::.|:||.|:
  Rat  1293 ---FAAPQAHKLDSVVVSSGKQSNPG------------------TTKRASPS---NSRRSSPGSS 1333

  Fly  1631 GSGTPGHGNNGGGEDSGIESMDALSEKSPHQLSSSSP--IQVSKAAVTMVQQQQQQTNAIVTITT 1693
            ...||                      ||.:.:|.:|  ...|:.:.|::|..:...|.:|
  Rat  1334 RKTTP----------------------SPGRQNSKAPKLTLASQTSTTLLQNMELPRNVLV---- 1372

  Fly  1694 SAAVIAPVIAPTSTQAGTTPTVAPSLQQQQKQQADDEIEKALAKMEGDFPDDLEDIVSSMIKETS 1758
                            |.||...|.|                   .|.||::
  Rat  1373 ----------------GPTPLANPPL-------------------SGSFPNN------------- 1389

  Fly  1759 ECASAAGGGFLNSLESSLPAATVATVV--STASTN-----------------TSSIGSIKLNGEH 1804
                    ..|||...::||..|.|||  :..|.|                 .:.:.::.:. |.
  Rat  1390 --------NGLNSQNPTVPAPAVGTVVEDNKESLNVPQDSDCQNSQGRKEQVNTELKAVPIQ-EA 1445

  Fly  1805 HILEHDDLIKK----LTESKPPAIKVK-------LEEMP------------PLLTIKKE-----P 1841
            .::..:|..||    |..:|.|:::..       :.|.|            |.:|||..     .
  Rat  1446 KMVVPEDQSKKDGQPLDPNKLPSVEENKTLMSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLE 1510

  Fly  1842 VIKPMASG--LKVEAKVEVKLEP-KVEPKSEEKLQEKPPSESSSASLQPISIEIPAQVDGETPRI 1903
            |..|..||  ||..:.:....:| ..||.:...|...  :|..|....|...|:.:.:....|.:
  Rat  1511 VTPPAVSGEDLKKASVIPTLQDPSSKEPSNSLNLPHS--NEPCSTLAHPELSEVSSNIAPSIPPV 1573

  Fly  1904 RTR--ASSRLESPLDAQKASPDPTTVTGVSTTAATAANAS------------TTVKSL------- 1947
            .:|  :||.:.:||     .|:..||...|....|::|.|            :||.::
  Rat  1574 MSRPVSSSSISTPL-----PPNQITVFVTSNPITTSSNTSAALPTHLQSALMSTVVTMPNVGNKV 1633

  Fly  1948 ------SRASSTASPRVVTPTPNHNNNNNKRRRQESECGSSNDGADLGENS-------------- 1992
                  |.|.|.|.|:.:||.  ..|:::..:..:....|:.....|..||
  Rat  1634 MVSEGQSAAQSNARPQFITPV--FINSSSIIQVMKGSQPSTIPATPLTTNSGLMPPSVAVVGPLH 1696

  Fly  1993 ----IK------RPRISSGTTSNN----------------------------------------- 2006
                ||      .|.:.|.:.:.|
  Rat  1697 IPQNIKFSSAPVTPNVPSSSPAPNIQTGRPLVLSSRATPVPLPSPPCTSSPVVAPNPSVQQVKEL 1761

  Fly  2007 NATETAAEHNAGAG---LPKKVEI------------ESSDSDEPLIEVAGKVRNSKQAQVEAADA 2056
            |..|.:.:.|..|.   ||.....            .|::...|:....||.:..|..|:....|
  Rat  1762 NPDEASPQTNTSADQSTLPSSQPTTVVSPLLANSPGSSANRRSPVSSSKGKGKVDKIGQILLTKA 1826

  Fly  2057 AAVGVEKHVT--RRNAQQLQPPQNKTAGNHAPSSTPAL------GTPRSGKAQAPVGATSAANNN 2113
            .     |.||  ....::......:|.|....::||.|      .|....|...|...|..
  Rat  1827 C-----KKVTGSLEKGEEQYGADGETEGPGLETTTPGLMGTEQCSTELDSKTPTPSAPTLL---- 1882

  Fly  2114 HNSSTANNASVVPSSVTT-TTMPGGAVVTTSQVNSGTSVVHATRGATAAAASTTNNNSASSP--- 2174
                ...::.:.|||.:| ..:|||| :.||..:..|::|.:...:||......:....|.|
  Rat  1883 ----KMTSSPMGPSSTSTGPILPGGA-LPTSVRSVVTTLVPSELISTAPTTKGNHGGITSEPLAG 1942

  Fly  2175 --TDEKIGTRRSVRASAAANKIIYSRSNAAA--------------AAAAAAAAAEPKGTTGKAGA 2223
              .:||:|:...:..|.|.::.:..:.:.|.              ||.|:..::|||.|..|
  Rat  1943 GLVEEKVGSHPELLPSIAPSQTLVPKESPATALQGSVGRPELEANAAIASGQSSEPKETVEK--- 2004

  Fly  2224 AVGANNAGNVESVAEARR--KTRSAVIGESMLTEGRRRRTSR 2263
                       |...:||  :|....:....:..|.|:|:||
  Rat  2005 -----------SKTPSRRNSRTEEPTMASENVENGHRKRSSR 2035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncoa6	NP_001097088.3	Nucleic_acid_bd	<12..>64	CDD:463988	26/54 (48%)
Ncoa6	NP_001263643.1	Nucleic_acid_bd	48..190	CDD:463988	40/115 (35%)
		PHA03247	<151..482	CDD:223021	96/375 (26%)
		Med15	377..>799	CDD:312941	106/428 (25%)
		PHA03247	<1052..1272	CDD:223021	62/240 (26%)
		Herpes_BLLF1	<1494..1813	CDD:282904	53/335 (16%)
		PHA03247	<1670..1937	CDD:223021	56/317 (18%)