DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncoa6 and ncoa6

DIOPT Version :9

Sequence 1:	NP_001097088.3	Gene:	Ncoa6 / 33761	FlyBaseID:	FBgn0031698	Length:	2467	Species:	Drosophila melanogaster
Sequence 2:	XP_004918586.2	Gene:	ncoa6 / 100496995	XenbaseID:	XB-GENE-982450	Length:	1920	Species:	Xenopus tropicalis

Alignment Length:	2355	Identity:	495/2355 - (21%)
Similarity:	767/2355 - (32%)	Gaps:	900/2355 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQLEP-SLVRILVSLPWDAAQRLRQLANDGNPELRALNIQSVQFEGDSVINLKV--GGQDIKITK 66
            |::|| :.||:..::|.:||:|||.||...|.:||.|.|.|||.||:..|||.:  ..|||::
Frog    83 QKVEPWNSVRVTFNIPREAAERLRLLAQSNNQQLRDLGILSVQIEGEGAINLALPHRAQDIRM-- 145

  Fly    67 DNVNETLEAAGSLSGNKSGLLATG---FDGPST------SKAASAFM----------------QQ 106
             |......:|..|.||.:....||   .:.||.      :..:||.|                .|
Frog   146 -NGPVAANSAMRLDGNFAMQGGTGIIRMNNPSMAMMSQGAHVSSAMMTPGGSNELMPRTPRPPSQ 209

  Fly   107 QQQRILQQPQNDAISLQQRRAAAAGLGLQ---------KMPLHTTQQQQQQQQQQQVAVTPAVFK 162
            |...|  .|....:::||....:..||.|         ..|:::...||.|||.:
Frog   210 QADTI--DPLVSGLNVQQSNHPSGSLGHQIHPMQNVVANRPMNSANFQQFQQQTR---------- 262

  Fly   163 SPNTVCPMEGKVPLLLPSPSATRDFPFESMRQARVLQGREAGGLGP---PLPP-----------P 213
                           ||             :.|:|.||......||   |:||           |
Frog   263 ---------------LP-------------QHAQVSQGMRQSFAGPSQVPIPPGWNQLASGALQP 299

  Fly   214 PPPNVTLKVLK------------TQQQQAPQNGEL-TPTTPTSAAPTPPGSKSQFIQPPPPPYP- 264
            ||....:..|.            .||||.||...| |..||:.               ||||||
Frog   300 PPAQTAIGTLNQGWKKSPMNTGPVQQQQFPQRPSLATVQTPSH---------------PPPPYPF 349

  Fly   265 GLGAATAS-----SVSSPIAIAGVSAKPAIVTAPSQLNHPLGHP-----PLPTATSTGSNNIAIS 319
            |...||.:     |:::|...:|...|| :...||::..||..|     |..:.:|:.......|
Frog   350 GSQQATQTHTSFPSMANPNQFSGPPGKP-LQGGPSRVTTPLQQPHLSKSPASSPSSSFQQGSPAS 413

  Fly   320 SPLLVNLLQNDGNGMSNPNQLKSPQQQQQQ---SP----LI--GMSPSGAQMMNSPMRSSGPAT- 374
            || .||.:|....|..:......||..|||   ||    :|  |.:..|..|..:|.::.||.|
Frog   414 SP-TVNQVQQQAMGPRSGQATPMPQGFQQQPVSSPSRGGMITQGTAAGGFMMQQAPQQNQGPQTI 477

  Fly   375 -----------------PSDFLMGDVLSPVVPSSPTTPQAAAPPCPPPVVMRNLQQQQQQHQQAM 422
                             .::||.|.          |.|.||..|...|    .||||.....||.
Frog   478 HAGVTKRLPPGFQAGQGNANFLQGQ----------TPPSAAGSPSNGP----GLQQQGSTSGQAT 528

  Fly   423 LSPSGN-ANHLYTQQQQQGPQQQQPQQQQQGPPHRFQQQHQQMSPQA----------VALRQQQL 476
            :..|.| ::|...|....||...|         :.....|..::.|.          :|....|.
Frog   529 VGGSVNGSSHSQMQVSHGGPNVMQ---------NNLMGIHSNLNNQQAGGSVVNQVNMASLHGQN 584

  Fly   477 QRQQQMRFMQPQQQL---QGQQQPQQQFQPAPDCFNNMGMGPM--QQQQI---RHQLRPGGLPLA 533
            |:..|...:..|||:   |||.            .|..|..|:  |.||:   |:||.|.|..:.
Frog   585 QQANQSHLLSMQQQIISSQGQM------------VNLQGQAPLNTQAQQLVLSRNQLMPQGQMMG 637

  Fly   534 PPPPHPQQQQQQRLMGLSMPQASPQQQFMSGASPLGPALSPASSHHSMHSPLMSNHQAQQQQQPQ 598
            ..|.....|..||:        :|.:|.:             .||:.|.:|   ..|:..||..|
Frog   638 TSPGQNMGQAPQRM--------TPPKQML-------------QSHNQMMTP---QGQSMMQQMEQ 678

  Fly   599 MVSPAATPGPTAPSEMAGQLMPANQHVPAAPPPDYNQAAVNSRWPLAGINKPMDSATKSSFQEFT 663
            ::.              |.....|...||......||.       :.|.|..:.:|
Frog   679 IIQ--------------GNKQGFNAQSPAGVMGGPNQI-------IRGANAGLQNA--------- 713

  Fly   664 RYQMQYNLQQQQQQVSLPGQPQQQ----------QQQPQQQQLPPPALPTQQQQQQQSH---VQQ 715
                         .|..|||..||          ..|.|..:.|.|.     |..||:|   |.|
Frog   714 -------------MVQFPGQVSQQGAVNNSSQGVNMQGQVLRAPVPG-----QHLQQTHGDGVAQ 760

  Fly   716 PQVAGQTQGQVDSLISLSVLDTLTTNDLDALLPTLN----------------------------- 751
            |                       .:||::|||.|:
Frog   761 P-----------------------GSDLNSLLPDLSMPPTGNMAPQHMQGMPGGSGPGQHFPGHG 802

  Fly   752 -----------------CDLDSTLSLEDKNELESLLQDAKDLDLDLIEDNLSA----VDMRDALN 795
                             |..:.:..|.....|.|      .|.::|::.::||    |:.:...|
Frog   803 LPFGSPFGQGGNGNQMGCGQNPSFPLNKDVTLTS------PLLVNLLQSDISAGHFGVNNKSNNN 861

  Fly   796 T-----LQEAPLEQQ-QQQQQQQAAMQPQQ----------------QTAQ-MMQMP-----YQQQ 832
            |     .::.|.::: ||.::|.:|.:|:.                :||| :.:.|     :..|
Frog   862 TPAKPKKKKPPRKKKNQQSEEQMSAPEPRMEDPDPLGIGGEQGGAVETAQKLSEFPNRPAGFPPQ 926

  Fly   833 PQQQQQMQQ---QLMMQQQQRQQQLPQMQQRQQQHLQRQLQLQQQQQQQQQQQLQIVQRQQQQQQ 894
            |.:|:.:||   |||                  |.|.:|.|.|..||....||:.::...|||.|
Frog   927 PVEQRSLQQIPSQLM------------------QQLGQQAQGQGGQQPTPPQQMMMMLMMQQQDQ 973

  Fly   895 SQLQVQHPQ-----------QPQRPPQK-----QFIINPH-TGDMEP------------------ 924
            ..:::..||           :.||.|.:     ..::|.| :|.:.|
Frog   974 KSVRLPGPQGEFNRRPSLNSEAQRMPMQPGGNMPVMVNVHGSGSIPPSPDKQRIPMAPNVSLGNN 1038

  Fly   925 ---MASDDSET-------EAEEETAQPQFRNSHSGLGSFNFNPA------NDMLLPTNLFSEEDS 973
               |...||..       ||...::.....:..:..|..|..|:      |.:::|.|......|
Frog  1039 GRKMGFPDSGNQSGSPLGEAPATSSLTDIPDQTAATGQQNNMPSHLLLSQNQLMMPGNKSGNLSS 1103

  Fly   974 NSAQQHPMGISSDQERSRDSL----------ASNKSATSRARKTPVSKANHSNF--SAGDNSPRS 1026
            .:..|   |.:..|::..:|:          ....|.|||. ||| ::|:...:  ...:|.|.|
Frog  1104 MTLSQ---GANPQQQQHANSMPGPHGHHFPSVQTPSQTSRP-KTP-NRASPRPYYPQTPNNRPPS 1163

  Fly  1027 SNSSPLIGLNSPQSVNAN-AGGAPSK-----KAKPNLLRGKLQQGVKERKAK------------D 1073
            :..|. |.| ||:.:||: ||..|.:     ..:|.|.||..|||:.....|            :
Frog  1164 TEPSE-ISL-SPERLNASIAGLFPPQINIPLPPRPTLNRGFDQQGLNPTTLKAIGQAPPGLTVNN 1226

  Fly  1074 PT--------AAPKQKRERAKGNVKTKAAEEKIKLRLK-LEKVETTPAAGAG--YEGQIIINQQQ 1127
            ||        .|.||     .||...|.|......|.. ....:|||:.|..  ...:.::..||
Frog  1227 PTGFLPSHNIVAGKQ-----TGNAGNKRASPSNSRRSSPASSRKTTPSPGRQNLKANKFVLGPQQ 1286

  Fly  1128 QQTIVVNNHMQQLPMQTQL----------------LALPTQQQQQQQQQQQQQQQQMQQPQMQIS 1176
            ...::.|..||:..||.|.                :::|......::.:...          .|:
Frog  1287 NPAMLHNLEMQRNAMQAQASMQSLVPGPPVGPYPPVSIPATCGLTEETKDSS----------AIT 1341

  Fly  1177 QQQHQQQQQTSQLQQQPAQLQ---QQQPQQQQQQPIQQQQQHHPVYSNFQQQQQQQQQQQQNVPG 1238
            |:...|..|.:..:|..|:|:   ||:.:...::  ..:::.||:              ....|.
Frog  1342 QEADSQAMQVAFKEQTEAELKAMVQQELKTTSEE--MSRKELHPM--------------DPCKPS 1390

  Fly  1239 PNEPRVPPLQIRLRGKNHVVVKNTRKDRKKGQNQEASIDE---RQLKRS---YSDQPPQQLLMDP 1297
            |.|...|            :|....:|.....:|  .:|.   ..||.|   .::.||.|||.|
Frog  1391 PAEEIKP------------MVSPAMRDAPTSLSQ--LLDHSAASSLKSSVVPITESPPLQLLSD- 1440

  Fly  1298 AESKQAKLTPPPHVNGLPILIQKTTATVASPQLPQQLQGGVATTTKTTTIVAGKNGLTISAIVEA 1362
                      .|.::.:             |.:|:.       |:....:|:..|.|   ..:..
Frog  1441 ----------DPKISDI-------------PPVPED-------TSNNNEVVSTPNPL---LQIGP 1472

  Fly  1363 HKAQAQAQAQ------SLNDPQLIVGSTNTGTTPTSTTLQQQQLSKIATSLP---SSITLSAINS 1418
            |.||.:..|.      |||.|...: ....|.|..|:::.|.|::...||.|   ||.|...:.|
Frog  1473 HAAQPKTDAMEPSTNVSLNLPSSAM-KRPAGQTSVSSSVSQSQITVFVTSNPITTSSTTTGPMTS 1536

  Fly  1419 NNNNNN-----VNSGNNNNRLLTMKNPIKTAATITPIVGGKPMTKNHKPPPYITAV-----QQLQ 1473
            :....:     ||..|..|:::..:              |:..:::...|.:||.|     ..:|
Frog  1537 HVQQQSLMPTVVNVQNMGNKVIVSE--------------GQQASQSTARPQFITPVFFNSPSIIQ 1587

  Fly  1474 LQKQQQQQQQQQQQQQQQQQQQQQRQLAAAVTMLPSATTLKRVEITKVTPQVTAEQAPSINPSPV 1538
            :.|..||..                        :|.:|:                 |.|.|.:|.
Frog  1588 VMKGSQQGN------------------------MPVSTS-----------------ASSSNLAPQ 1611

  Fly  1539 VVAAAATATLTTSSTPTTQTTQLICDRKLPVAMPPMTTVNNVVVATVNSSSAALSTLSSVSTASS 1603
            .||       ...|....|..|.       .|.||             ||:...|.::|:.|...
Frog  1612 SVA-------VVGSLHIPQNIQF-------SAGPP-------------SSTPPSSAVTSMQTTRP 1649

  Fly  1604 ASIITTSTSTSSPAALPSTLRNSPASNGSGTPGHGNNGGGEDSGIESMDALSEKSPHQLSSSSPI 1668
            . ::|...:|:.||..||.:   |..    ||...:|  .||.. .::...||:.|...|.
Frog  1650 V-LVTPPQNTAHPAQSPSVV---PPP----TPFKESN--KEDIS-SNLGVASEECPPGPSK---- 1699

  Fly  1669 QVSKAAVTMVQQQQQQTNAIVTITTSAAVIAPVIAPTSTQAGTTPTVAPSLQQQQKQQADDEIEK 1733
                                           |:::|.|                      |.:..
Frog  1700 -------------------------------PMVSPPS----------------------DSVRN 1711

  Fly  1734 ALAKMEGDFP--DDLEDIVSSMIKETSECASAAGGGFLNSLESSL----------PAATVATVVS 1786
            :.|..:|. |  |..|.::.:.:.:     :..||...:|||::.          |.|.:||...
Frog  1712 STASSKGQ-PKVDQTEQLMFTTVNK-----NVTGGILKDSLETNKDELGDGDKTPPLANLATTDP 1770

  Fly  1787 TASTNTSSIGSIKLNGEHHILEHDDLIKKLTESKPPAIKVKLEEMPPLLTIKKEPVIKPMASGLK 1851
            ..:|..||                                  :.:.|.....||.|..|.|:...
Frog  1771 EVTTAISS----------------------------------DSLCPQNPSSKEGVPAPSAAQSS 1801

  Fly  1852 VEAK-------VEVKLEPKVEPKSEEKLQEKPPSESSSASLQPIS-------------IEIPAQV 1896
            :..:       |..|.:..::..|.|..||...|:||....:|.|             .:||...
Frog  1802 IHGEFKHVGNTVPEKNDTTLDNVSAETTQETASSKSSRQEERPASNKESAPEKPGDDPQDIPESE 1866

  Fly  1897 DGETPRIRTRASSRLESPLDAQKASPDPTTVTGVSTTAATAANASTTVKSLSRASSTASPRVVTP 1961
            ..|.|:..:|.:|::|.|.:|.:        :|....:|...:||:       ..|.|||
Frog  1867 ATERPKPLSRRNSKMEEPPEALE--------SGQRKRSARPGSASS-------KESGASP----- 1911

  Fly  1962 TPNHNNNNNKRRRQE 1976
                  ...|||:.:
Frog  1912 ------TQPKRRKSK 1920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncoa6	NP_001097088.3	Nucleic_acid_bd	<12..>64	CDD:290532	26/53 (49%)
ncoa6	XP_004918586.2	Nucleic_acid_bd	45..183	CDD:372737	38/102 (37%)
		Med15	137..>475	CDD:312941	96/397 (24%)
		Med15	418..>787	CDD:312941	109/498 (22%)
		PTZ00449	<1094..>1195	CDD:185628	28/107 (26%)
		PRK13108	<1766..1914	CDD:237284	39/207 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4469
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008009
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4925
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.080