DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IARS1 and IleRS

DIOPT Version :9

Sequence 1:	NP_001365498.1	Gene:	IARS1 / 3376	HGNCID:	5330	Length:	1283	Species:	Homo sapiens
Sequence 2:	NP_524840.2	Gene:	IleRS / 45785	FlyBaseID:	FBgn0027086	Length:	1229	Species:	Drosophila melanogaster

Alignment Length:	1260	Identity:	679/1260 - (53%)
Similarity:	887/1260 - (70%)	Gaps:	85/1260 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     4 QVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIV 68
            :||||||||||||.:|:.|...|.|::|.:.||.|||:|||||||||||||||||||||||||||
  Fly    12 RVPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIV 76

Human    69 TRYAHQSGFHVDRRFGWDCHGLPVSCIVAVVFIGQRGNSLITNFQEYEIDKTLGIRGPEDVAKMG 133
            ||||:|.|:|||||||||||||||                     |:||||.|.|:|||||||||
  Fly    77 TRYAYQQGYHVDRRFGWDCHGLPV---------------------EFEIDKLLNIKGPEDVAKMG 120

Human   134 ITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVK 198
            |..||.:||.|||||:.||::.|:|:||||||.||||||||.:|||:||:||||:||||||:|||
  Fly   121 IAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVK 185

Human   199 VMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSL-----VAWTTTPWTLPSNLAVC 258
            |||:||||.|.|||||::||||:|.||.|.|..     |.|||     :.|||||||||||.|.|
  Fly   186 VMPYSTACTTSLSNFEANQNYKEVVDPCVVVAL-----EAVSLPNTFFLVWTTTPWTLPSNFACC 245

Human   259 VNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLK-CKE 322
            |:|.|.|||::||...||.:|.|:|||.:||.|::||:.|:|.|..||...|:|||.||.| ..|
  Fly   246 VHPTMTYVKVRDVKSDRLFVLAESRLSYVYKSETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGAE 310

Human   323 NGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFA 387
            ..|:.||||.||.|:.|||:||.|||||.:|||||:...:|.|.|..:||||.:|.||.|.:||.
  Fly   311 VKAYRVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFE 375

Human   388 GQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNND 452
            ||||||:||.|:..||.:|.|:.:....||||||||||||||||||||||||||:|...||..:.
  Fly   376 GQYVKDSDKQIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSS 440

Human   453 LCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKIS 517
            ..||||:.|:|||||||||:||||.||||||||||||:|.|...:|.|.|||:.:|.||||.::.
  Fly   441 QTYWVPDFVKEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVVIGSIKQLAELSGVQVE 505

Human   518 DLHRESVDHLTIPSRC-GKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEG 581
            ||||||:||:.|||.. |...|.||:.||||||||||||:||.|:||||:::|.:.|||||||||
  Fly   506 DLHRESIDHIEIPSAVPGNPPLRRIAPVFDCWFESGSMPFAQQHFPFENEKDFMNNFPADFIAEG 570

Human   582 IDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRL 646
            |||||||||||||::||||.:.||||:|.:|||||:|||||||||||||||:.::.|||||||||
  Fly   571 IDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRL 635

Human   647 YLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEE---EIEFLYN-ENTVR 707
            |||||||||||:||||||||||::|||.||||||||||:||::|.:||:   ..::.|: |..::
  Fly   636 YLINSPVVRAESLRFKEEGVRDIIKDVFLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERHLK 700

Human   708 --ESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGME 770
              :..::.|.|||||.:||:.||.|||..||||||||||.||:|.|||||||:||||:|||.|.:
  Fly   701 NMDKASVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFIDQLTNWYVRLNRRRIKGELGAD 765

Human   771 DCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPV-SVQDKDTLSIHYLMLPRVREEL 834
            .|:.:|:||:.||.::.::|||:||:|||.::|.| ||..|. :::..|  |:||.|:|..:::.
  Fly   766 QCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRL-VLFQPAGTLEHAD--SVHYQMMPVSQKKF 827

Human   835 IDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRK 899
            |....|.:|:.||||:|||||:|||:|:|:|||:.||:.||:|.:.|:.||:|:.:|:.||||||
  Fly   828 IRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRK 892

Human   900 VTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDE 964
            :|||:||.|||:.|||||||..||:||||.|||||.:||.|..:|:::....|...:....:..:
  Fly   893 LTLSSDKEKYGVTLRAEPDHKALGQRLKGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQRIELD 957

Human   965 DIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDE 1029
            ::|::|...:..||  .||||||.:.|||||:||::.:::||:|||||||:|||:||..|:|||.
  Fly   958 EVRIIYCTSEQVGG--NFEAHSDNEVLVLLDMTPNEELLEEGLAREVINRVQKLKKKAQLIPTDP 1020

Human  1030 ITVYY------KAKSE----GTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDK--VLIQEKTQLK 1082
            :.:::      |||.|    ...|..|:.::...|.|.||:...||....:.|  ::..|...||
  Fly  1021 VLIFHELAADNKAKQEVLEAQAQLAKVLSNYASIIKTAIKSEFAPYSSEQASKKRLIASELVDLK 1085

Human  1083 GSELEITLTRGSSLPGPACAYVNLNICAN-----GSEQGGVLLLENPKGDNRLDLLKLKSVVTSI 1142
            |..|::|:.....|..|...::|:::..:     |:.....|.|::......:.|..|:|.:..:
  Fly  1086 GVPLKLTICSTEELQLPNLPWLNISLAEDLVPRFGNSSKASLFLQHNVSKEIISLPTLRSELEHL 1150

Human  1143 FGVKNTELAVFHDETEIQNQTDLL-----SLSGKTLCVT-AGSAPSL---INSSSTLLCQYINLQ 1198
            ||:......::  ..:.|.:|..|     :||||.|.:| :..||.|   ...|.....::||..
  Fly  1151 FGLYGVNFNIY--VVDHQKRTTALKSIDENLSGKLLVLTRSQDAPKLSAGYELSPAPYSKFINQH 1213

Human  1199 LLNAKPQECLMGTVGTLLLENPLGQ 1223
              :.|          ::..|||||:
  Fly  1214 --SGK----------SIFTENPLGR 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IARS1	NP_001365498.1	PLN02882	6..1092	CDD:215477	646/1111 (58%)
		'HIGH' region	48..58		9/9 (100%)
		'KMSKS' region	621..625		3/3 (100%)
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	647/1112 (58%)
		IleRS_core	47..>189	CDD:173909	114/162 (70%)
		IleRS_core	<373..650	CDD:173909	193/276 (70%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	103/199 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158466
Domainoid	1	1.000	886	1.000	Domainoid score	I53
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5325
Inparanoid	1	1.050	1347	1.000	Inparanoid score	I143
Isobase	1	0.950	-	0	Normalized mean entropy	S440
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	1	1.000	-	-		FOG0004669
OrthoInspector	1	1.000	-	-		oto90031
orthoMCL	1	0.900	-	-		OOG6_100811
Panther	1	1.100	-	-	LDO	PTHR42780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3282
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.760