DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vri and TEF

DIOPT Version :9

Sequence 1:	NP_001137792.1	Gene:	vri / 33759	FlyBaseID:	FBgn0016076	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_003207.1	Gene:	TEF / 7008	HGNCID:	11722	Length:	303	Species:	Homo sapiens

Alignment Length:	219	Identity:	60/219 - (27%)
Similarity:	83/219 - (37%)	Gaps:	65/219 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PRPPTGGKEEKLLLLAP-PGKLYPEASVSTAMPEVLSGTPTNSHNKANIAMMNNVRLSNISPTLS 153
            |..||......||.:|. .||  ..||.|||.|      |::|           ..:...|.|:|
Human   111 PASPTHLAHNLLLPVAELEGK--ESASSSTASP------PSSS-----------TAIFQPSETVS 156

  Fly   154 MNGSSNEASNLHPLSMYGGSISPQSN-DSGMSDSLGKYVPGSGYGDGMMAQSPSQGGNGPQSALT 217
            ...||.|.....|..:....:....| :...:|.:...|||.
Human   157 STESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGG----------------------- 198

  Fly   218 AAQKELFSQRK-----------------QREFTPDNKKDESYWDRRRRNNEAAKRSREKRRYNDM 265
                |||:.||                 ::.|.||.:|||.||.||::||.||||||:.||..:.
Human   199 ----ELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKEN 259

  Fly   266 VLEQRVIELTKENHVLKAQLDAIR 289
            .:..|...|.|||..|:.::..:|
Human   260 QITIRAAFLEKENTALRTEVAELR 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vri	NP_001137792.1	bZIP_NFIL3	238..297	CDD:269842	24/52 (46%)
vri	NP_001137792.1	coiled coil	239..297	CDD:269842	23/51 (45%)
TEF	NP_003207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..176		15/60 (25%)
		bZIP_HLF	232..290	CDD:269843	24/52 (46%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	235..255		12/19 (63%)
		coiled coil	236..287	CDD:269843	21/48 (44%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	256..263		0/6 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810