DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vri and nfil3

DIOPT Version :9

Sequence 1:	NP_001137792.1	Gene:	vri / 33759	FlyBaseID:	FBgn0016076	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001015710.1	Gene:	nfil3 / 548427	XenbaseID:	XB-GENE-479624	Length:	462	Species:	Xenopus tropicalis

Alignment Length:	640	Identity:	138/640 - (21%)
Similarity:	221/640 - (34%)	Gaps:	257/640 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 PTLSMN----GSSNEASNLHPLSMYGGSISPQSNDSGMSDSLGKYVPGSG---YGDGMMAQSPSQ 207
            ||:...    .|.|...|:..||         ||...||:|:    ..|.   |.:|    :|::
Frog     7 PTIKREQECADSRNNMENILVLS---------SNIPDMSESM----DSSNDMLYSEG----APAK 54

  Fly   208 GGNGPQSALTAAQKELFSQRKQREFTPDNKKDESYWDRRRRNNEAAKRSREKRRYNDMVLEQRVI 272
            ..|.             |.|::|||.||.|||..||::||:|||||||||||||.||||||.::|
Frog    55 NKNS-------------SCRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDMVLENKLI 106

  Fly   273 ELTKENHVLKAQLDAIRDKFNI--SGENLVSVEKILASLPTSEQVLSNTKRAKMSGSGGSSSGSS 335
            .|.:||..||.:|.:::.||.:  |......::|:..|.....|..|::|...||.:........
Frog   107 ALGEENASLKTELLSLKLKFGLISSASYAQEIQKVTTSTAMYFQEYSSSKPNVMSYNSDHEHSVM 171

  Fly   336 PSGSGSGEGSPQGGHNGYPVGPPLSPLIYGPNGNARPEATVKSVHHIHHAGVAPPPTHLQQLVVP 400
            .|..                   :|.:.:.|..:....:...||.|:
Frog   172 TSSC-------------------ISVIKHSPQSSLSDVSEASSVEHV------------------ 199

  Fly   401 QSQTQHLYQPQPQQHQPHQQ----QQISQPPQQQQQQQEPSPSAGSSSPVISDPHNRPPSTTIAN 461
                    ||...|......    |:|.|.|.:::.
Frog   200 --------QPSTVQSNCRSTDINFQRIKQEPMEREN----------------------------- 227

  Fly   462 LQVQLQQALNRNVRPEDLDSLRKVVAAGALYNAAAVVGAPPPPPSAGLYVPAPSAYKDHLEAAAA 526
                    .:|:.| ||.::.:     |::|..               |:.         ...:.
Frog   228 --------FSRDAR-EDSNTFQ-----GSIYTN---------------YIG---------NTFSG 254

  Fly   527 WSHNVEAAVSSSAVDAVSSSSVSGSAASVLNLSRRACSPSYEHMLSSTTSSTLSSASSSGAV--- 588
            :||                                  ||...|:..|:::|..:|.:..|.|
Frog   255 YSH----------------------------------SPPLLHINRSSSNSPRTSEADEGVVGKT 285

  Fly   589 -SGDDEQE--HEPAHMAPLQLQRSS------PQQGSDANNCLPLKLRHKS-------HLGDKDAA 637
             .|:|||:  ..|.| :|::|:...      |:..|.|   ||.|||.|:       ...:.:..
Frog   286 SDGEDEQQVPKGPIH-SPVELKNGHTTIIKVPEVNSSA---LPHKLRIKAKAMQIKVEALESELN 346

  Fly   638 ATALLSL-------QHIKQEPNCSRASPPAWNDGGDNSSDERDSGISIASAEWTAQLQRKLLAPK 695
            :|..|:|       :|::.|.:              ||.....|.:|..|.:.| .:|...|.|.
Frog   347 STQKLTLPIDMSSKRHLQLEKH--------------NSETMVHSSLSPLSVQVT-NIQDWPLKPG 396

  Fly   696 E----------------------ANVVTSAERDQM-LKSQLERLESEVASIKMIL 727
            :                      .||..::|.:.: ||..:..|.:|||::|.::
Frog   397 QWHHRELDKIPSVCKTSGIVDIKDNVFKASESESLYLKQGIANLSAEVATLKRLI 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vri	NP_001137792.1	bZIP_NFIL3	238..297	CDD:269842	35/60 (58%)
vri	NP_001137792.1	coiled coil	239..297	CDD:269842	34/59 (58%)
nfil3	NP_001015710.1	bZIP_NFIL3	72..131	CDD:269842	34/58 (59%)
		coiled coil	73..131	CDD:269842	33/57 (58%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	79..95		13/15 (87%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	101..122		9/20 (45%)
		Vert_IL3-reg_TF	130..461	CDD:368956	79/487 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..304		13/41 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9444
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1450431at2759
OrthoFinder	1	1.000	-	-		FOG0002055
OrthoInspector	1	1.000	-	-		otm48977
Panther	1	1.100	-	-	O	PTHR15284
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5136
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.050