DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vri and NFIL3

DIOPT Version :9

Sequence 1:	NP_001137792.1	Gene:	vri / 33759	FlyBaseID:	FBgn0016076	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001276928.1	Gene:	NFIL3 / 4783	HGNCID:	7787	Length:	462	Species:	Homo sapiens

Alignment Length:	628	Identity:	132/628 - (21%)
Similarity:	215/628 - (34%)	Gaps:	218/628 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 VRLSNISPTLSMNGSSNEASNLHPLSMYGGSISPQSNDSGMSDSLGKYVPGSGYGDGMMAQSPSQ 207
            ::|..:........|.:.:||:..:.:...:::..|.||..             |:.::....|.
Human     1 MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTT-------------GEELLLSEGSV 52

  Fly   208 GGNGPQSALTAAQKELFSQRKQREFTPDNKKDESYWDRRRRNNEAAKRSREKRRYNDMVLEQRVI 272
            |.|...:.           |::|||.||.|||..||::||:|||||||||||||.||:|||.::|
Human    53 GKNKSSAC-----------RRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLI 106

  Fly   273 ELTKENHVLKAQLDAIRDKFNISGENLVSVEKILASLPTSEQVLSNTKRAKMSGSGGSSSGSSPS 337
            .|.:||..|||:|.:::.||.:......:.|  :..|..|..|.....:...|..........||
Human   107 ALGEENATLKAELLSLKLKFGLISSTAYAQE--IQKLSNSTAVYFQDYQTSKSNVSSFVDEHEPS 169

  Fly   338 GSGSGEGSPQGGHNGYPVGPPLSPLIYGPNGNARPEATVKSVHHIHHAGVAPPPTHLQQLVVPQS 402
            ...|.               .:|.:.:.|..:....:.|.||.|...:.|
Human   170 MVSSS---------------CISVIKHSPQSSLSDVSEVSSVEHTQESSV--------------- 204

  Fly   403 QTQHLYQPQPQQHQPHQQQQI--SQPPQQQQQQQEPSPSAGSSSPVISDPHNRPPSTTIANLQVQ 465
                    |.....|..:.||  .:|.:.:...:||....||
Human   205 --------QGSCRSPENKFQIIKQEPMELESYTREPRDDRGS----------------------- 238

  Fly   466 LQQALNRNVRPEDLDSLRKVVAAGALYNAAAVVGAPPPPPSAGLYVPAPSAYKDHL-EAAAAWSH 529
                                      |.|                    |.|:::: .:.:.:||
Human   239 --------------------------YTA--------------------SIYQNYMGNSFSGYSH 257

  Fly   530 NVEAAVSSSAVDAVSSSSVSGSAASVLNLSRRACSPSYEHMLSSTTSSTLSSASSSGAV----SG 590
                                              ||....:..|:::|..:|.:..|.|    .|
Human   258 ----------------------------------SPPLLQVNRSSSNSPRTSETDDGVVGKSSDG 288

  Fly   591 DDEQE--HEPAHMAPLQLQR------SSPQQGSDANNCLPLKLRHKS-------HLGDKDAAATA 640
            :|||:  ..|.| :|::|:.      ..|:..|.|   ||.|||.|:       ...|.:..||.
Human   289 EDEQQVPKGPIH-SPVELKHVHATVVKVPEVNSSA---LPHKLRIKAKAMQIKVEAFDNEFEATQ 349

  Fly   641 LL-------SLQHIKQE----PNCSRASPPAWNDGGDNSSDERDSGISIASAEW-TAQLQRK--- 690
            .|       |.:|.:.|    |:...:|...::....|..|     .|:.|..| ..:|..|
Human   350 KLSSPIDMTSKRHFELEKHSAPSMVHSSLTPFSVQVTNIQD-----WSLKSEHWHQKELSGKTQN 409

  Fly   691 -----LLAPKEANVVTSAERDQMLKSQLERLESEVASIKMILA 728
                 ::..|::....|...:..||..:..|.:||.|:|.::|
Human   410 SFKTGVVEMKDSGYKVSDPENLYLKQGIANLSAEVVSLKRLIA 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vri	NP_001137792.1	bZIP_NFIL3	238..297	CDD:269842	34/58 (59%)
vri	NP_001137792.1	coiled coil	239..297	CDD:269842	33/57 (58%)
NFIL3	NP_001276928.1	bZIP_NFIL3	72..131	CDD:269842	34/58 (59%)
		coiled coil	76..127	CDD:269842	31/50 (62%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	79..95		13/15 (87%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	99..106		3/6 (50%)
		Vert_IL3-reg_TF	130..461	CDD:368956	80/475 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..237		12/70 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..302		13/44 (30%)
		Necessary for transcriptional repression and sufficient for interaction with DR1. /evidence=ECO:0000269\|PubMed:8836190	299..363		17/67 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144841
Domainoid	1	1.000	71	1.000	Domainoid score	I9446
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1450431at2759
OrthoFinder	1	1.000	-	-		FOG0002055
OrthoInspector	1	1.000	-	-		otm41756
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15284
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5136
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.880