Protein Alignment vri and ATF4

DIOPT Version :9

• Sequence 1: NP_001137792.1
• Gene: vri / 33759
• FlyBaseID: FBgn0016076
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001666.2
• Gene: ATF4 / 468
• HGNCID: 786
• Length: 351
• Species: Homo sapiens
• Alignment Length: 235
• Identity: 56/235 - (23%)
• Similarity: 81/235 - (34%)
• Gaps: 48/235 - (20%)

  Fly    87 PYGPRPPTGGKEEKLLLLAPPGKLYPEASVSTAMPEVLSGTPTNSHNKANIAMMNNVRLSNISPT 151
            |.|..|.:..|.::   :||...|.|    ....|.|||.||.:|                .|..
Human   140 PIGHLPESLTKPDQ---VAPFTFLQP----LPLSPGVLSSTPDHS----------------FSLE 181

  Fly   152 LSMNGSSNEASNLHPLSMYGGSI--------SPQSNDSGMSDSLGKYVPGSGYGDGMMAQSPSQG 208
            |.......|.......:.|...|        :|..||||:..|...|:       |....|||..
Human   182 LGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYL-------GSPQHSPSTR 239

  Fly   209 GNGPQSALTAAQKELFSQRKQREFTPDNK---------KDESYWDRRRRNNEAAKRSREKRRYND 264
            |: |..:|.:......|.|.:....|..|         |.:....:..:|..||.|.|:|:|...
Human   240 GS-PNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKRAEQ 303

  Fly   265 MVLEQRVIELTKENHVLKAQLDAIRDKFNISGENLVSVEK 304
            ..|.....||.|:|..||.:.|::..:.....:.:..|.|
Human   304 EALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRK 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vri	NP_001137792.1	bZIP_NFIL3	238..297	CDD:269842	16/58 (28%)
		coiled coil	239..297	CDD:269842	15/57 (26%)
ATF4	NP_001666.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..268		17/65 (26%)
		BetaTrCP degron motif. /evidence=ECO:0000269|PubMed:11238952	215..224		4/8 (50%)
		bZIP_ATF4	279..341	CDD:269840	15/61 (25%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	280..300		6/19 (32%)
		coiled coil	281..340	CDD:269840	15/58 (26%)
		Interaction with GABBR1. /evidence=ECO:0000250	305..341		8/35 (23%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	306..334		8/27 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910