DRSC/TRiP Functional Genomics Resources

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Protein Alignment vri and Nfil3

DIOPT Version :9

Sequence 1:NP_001137792.1 Gene:vri / 33759 FlyBaseID:FBgn0016076 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_059069.1 Gene:Nfil3 / 18030 MGIID:109495 Length:462 Species:Mus musculus


Alignment Length:598 Identity:133/598 - (22%)
Similarity:211/598 - (35%) Gaps:204/598 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 ISPQSNDSGM---SDSLGKYVPGSGYGDGMMAQSPSQGGNGPQSALTAAQKELFSQRKQREFTPD 235
            :.|.|:...|   :.:|.:.......|:.::....|.|.|...:.           |::|||.||
Mouse    16 LDPTSSSDKMLLLNSALAEVAEDLASGEDLLLNEGSMGKNKSSAC-----------RRKREFIPD 69

  Fly   236 NKKDESYWDRRRRNNEAAKRSREKRRYNDMVLEQRVIELTKENHVLKAQLDAIRDKFNISGENLV 300
            .|||..||::||:|||||||||||||.||:|||.::|.|.:||..|||:|.:::.||.:......
Mouse    70 EKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAY 134

  Fly   301 SVEKILASLPTSEQVLSNTKRAKMSGSGGSSSGSSPSGSGSGEGSPQGGHNGYPVGPPLSPLIYG 365
            :.|         .|.|||:..........|.:..|   |...|..|     ....|..:|.:.:.
Mouse   135 AQE---------IQKLSNSTAVYFQDYQTSKAAVS---SFVDEHEP-----AMVAGSCISVIKHS 182

  Fly   366 PNGNARPEATVKSVHHIHHAGVAPPPTHLQQLVVPQSQTQHLYQPQPQQHQPHQQQQISQPPQQQ 430
            |..:....:.|.||.|                      ||.                        
Mouse   183 PQSSLSDVSEVSSVEH----------------------TQE------------------------ 201

  Fly   431 QQQQEPSPSAGSSSPVISDPHNRPPSTTIANLQVQLQQALNRNVRPEDLDSLRKVVAAGALYNAA 495
                  ||:.|.    ...|.|:.|  .|....|:| ::..|..|.|                  
Mouse   202 ------SPAQGG----CRSPENKFP--VIKQEPVEL-ESFAREAREE------------------ 235

  Fly   496 AVVGAPPPPPSAGLYVPAPSAYKDHLEAA-AAWSHNVEAAVSSSAVDAVSSSSVSGSAASVLNLS 559
                       .|.|  :.|.|:.::.:: :.:||                              
Mouse   236 -----------RGTY--STSIYQSYMGSSFSTYSH------------------------------ 257

  Fly   560 RRACSPSYEHMLSSTTSSTLSSASSSGAV----SGDDEQE--HEPAHMAPLQLQR------SSPQ 612
                ||....:..||::|..:|.:..|.|    .|:|||:  ..|.| :|::|||      ..|:
Mouse   258 ----SPPLLQVHGSTSNSPRTSEADEGVVGKSSDGEDEQQVPKGPIH-SPVELQRVHATVVKVPE 317

  Fly   613 QGSDANNCLPLKLRHKSHL-------------GDKDAAATA-LLSLQHIKQEPN----CSRASPP 659
            ....|   ||.|||.|:..             |.:..::.| .::.:|...|.:    .:.:|.|
Mouse   318 VNPSA---LPHKLRIKAKAMQVKVEALDSEFEGMQKLSSPADAIAKRHFDLEKHGTSGMAHSSLP 379

  Fly   660 AWNDGGDNSSDERDSGISIASAEW---------TAQLQRKLLAPKEANVVTSAERDQMLKSQLER 715
            .::....|..|     .|:.|..|         .:..:..::..|:.....|...:..||..:..
Mouse   380 PFSVQVTNIQD-----WSLKSEHWHHKELSSKTQSSFKTGVVEVKDGGYKVSEAENLYLKQGIAN 439

  Fly   716 LESEVASIKMILA 728
            |.:||.|:|..:|
Mouse   440 LSAEVVSLKRFIA 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vriNP_001137792.1 bZIP_NFIL3 238..297 CDD:269842 34/58 (59%)
coiled coil 239..297 CDD:269842 33/57 (58%)
Nfil3NP_059069.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 2/5 (40%)
bZIP_NFIL3 72..131 CDD:269842 34/58 (59%)
coiled coil 76..127 CDD:269842 31/50 (62%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 79..95 13/15 (87%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 99..106 3/6 (50%)
Vert_IL3-reg_TF 130..461 CDD:368956 84/473 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 188..214 10/81 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..298 11/38 (29%)
Necessary for transcriptional repression and sufficient for interaction with PER2. /evidence=ECO:0000269|PubMed:17274955 281..420 30/147 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834949
Domainoid 1 1.000 71 1.000 Domainoid score I9398
eggNOG 1 0.900 - - E1_KOG3119
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002055
OrthoInspector 1 1.000 - - otm43807
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15284
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5136
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.870

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