DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vri and DBP

DIOPT Version :9

Sequence 1:	NP_001137792.1	Gene:	vri / 33759	FlyBaseID:	FBgn0016076	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001343.2	Gene:	DBP / 1628	HGNCID:	2697	Length:	325	Species:	Homo sapiens

Alignment Length:	237	Identity:	58/237 - (24%)
Similarity:	90/237 - (37%)	Gaps:	90/237 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PRPPTGGKEEKLLLLAPPGKLYPEASVSTAMPEVLSGTPTNSHNKANIAMMNNVRLSNISPTLSM 154
            |.||            |||...||.|.:.        ||..|....:.
Human   130 PSPP------------PPGGPSPEPSPAR--------TPAPSPGPGSC----------------- 157

  Fly   155 NGSSNEASNLHPLSMYGGSISPQSNDSGMSDSLGKYVPGSGYGDGMMAQ-SPSQGGNGPQS---- 214
                             ||.||:|: .|.:.:.......||:..|:.:: :||.  ..|.:
Human   158 -----------------GSASPRSS-PGHAPARAALGTASGHRAGLTSRDTPSP--VDPDTVEVL 202

  Fly   215 ----------ALTA--------------AQKELFSQ---RKQREF-TPDNKKDESYWDRRRRNNE 251
                      ||::              :::||..|   :|.|:. .|:.:|||.||.||.:|||
Human   203 MTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNE 267

  Fly   252 AAKRSREKRRYNDMVLEQRVIELTKENHVLKAQLDAIRDKFN 293
            ||||||:.||..:..:..|...|.|||.:|:.::.|:|.:.:
Human   268 AAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELS 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vri	NP_001137792.1	bZIP_NFIL3	238..297	CDD:269842	26/56 (46%)
vri	NP_001137792.1	coiled coil	239..297	CDD:269842	25/55 (45%)
DBP	NP_001343.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..200		24/126 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..255		6/25 (24%)
		bZIP_HLF	254..313	CDD:269843	26/56 (46%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	257..279		15/21 (71%)
		coiled coil	258..309	CDD:269843	23/50 (46%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	283..297		5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810