DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vri and Atf4

DIOPT Version :9

Sequence 1:	NP_001137792.1	Gene:	vri / 33759	FlyBaseID:	FBgn0016076	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001274109.1	Gene:	Atf4 / 11911	MGIID:	88096	Length:	349	Species:	Mus musculus

Alignment Length:	243	Identity:	55/243 - (22%)
Similarity:	85/243 - (34%)	Gaps:	71/243 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PTGGKEEKLL---LLAPPGKLYPEASVSTAMPEVLSGTPTNSHNKANIAMMNNVRLSN------- 147
            |.|...|.|:   .:||...|.|    ....|.|||.||.:|.   ::.:.:.|.:|.
Mouse   139 PIGHLPESLIKVDQVAPFTFLQP----FPCSPGVLSSTPEHSF---SLELGSEVDISEGDRKPDS 196

  Fly   148 ------ISPTLSMNGSSNEASNLHPLSMYGGSISPQSNDSGMSDSLGKYVPGSGYGDGMMAQS-- 204
                  |.|.:....                  :|..||||:..|...|: ||.......:::
Mouse   197 AAYITLIPPCVKEED------------------TPSDNDSGICMSPESYL-GSPQHSPSTSRAPP 242

  Fly   205 ---PSQGG----------NGPQSALTAAQKELFSQRKQREFTPDNKKDESYWDRRRRNNEAAKRS 256
               ||.||          :.|..:|||..|              .:|.:....:..:|..||.|.
Mouse   243 DNLPSPGGSRGSPRPKPYDPPGVSLTAKVK--------------TEKLDKKLKKMEQNKTAATRY 293

  Fly   257 REKRRYNDMVLEQRVIELTKENHVLKAQLDAIRDKFNISGENLVSVEK 304
            |:|:|.....|.....||.|:|..||.:.|::..:.....:.:..|.|
Mouse   294 RQKKRAEQEALTGECKELEKKNEALKEKADSLAKEIQYLKDLIEEVRK 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vri	NP_001137792.1	bZIP_NFIL3	238..297	CDD:269842	16/58 (28%)
vri	NP_001137792.1	coiled coil	239..297	CDD:269842	15/57 (26%)
Atf4	NP_001274109.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..271		18/85 (21%)
		BetaTrCP degron motif. /evidence=ECO:0000269\|PubMed:23663782	214..223		4/8 (50%)
		bZIP_ATF4	277..339	CDD:269840	15/61 (25%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	278..298		6/19 (32%)
		coiled coil	279..338	CDD:269840	15/58 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..298		6/18 (33%)
		Interaction with GABBR1. /evidence=ECO:0000250	303..339		8/35 (23%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	304..332		8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910