DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vri and CEBPE

DIOPT Version :9

Sequence 1:	NP_001137792.1	Gene:	vri / 33759	FlyBaseID:	FBgn0016076	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001796.2	Gene:	CEBPE / 1053	HGNCID:	1836	Length:	281	Species:	Homo sapiens

Alignment Length:	265	Identity:	55/265 - (20%)
Similarity:	93/265 - (35%)	Gaps:	70/265 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 HYSQQKLSGSDFPYGPRPPTGGKEEKLL---LLAPPGKLYPEASVSTAMPEVLSGTPTNSHNKAN 136
            ||    |.....|:...|.|.|.:.|.|   :.:.||...|.|......|....|:...|....|
Human    79 HY----LPPDPRPFAYPPHTFGPDRKALGPGIYSSPGSYDPRAVAVKEEPRGPEGSRAASRGSYN 139

  Fly   137 -----IAMMNNVRLSNISPTLSMNGSSNEASNLHPLSMYGGSISPQSNDSGMSDSLGKYVPGSGY 196
                 :|......: ::.|||:..|........ ||:......||
Human   140 PLQYQVAHCGQTAM-HLPPTLAAPGQPLRVLKA-PLATAAPPCSP-------------------- 182

  Fly   197 GDGMMAQSPSQGGNGPQSALTAAQKELFSQRKQREFTPDNKKDESYWDRRRRNNEAAKRSREKRR 261
                :.::||     |...|...:|.:            ||....|..||.|||.|.::||:|.:
Human   183 ----LLKAPS-----PAGPLHKGKKAV------------NKDSLEYRLRRERNNIAVRKSRDKAK 226

  Fly   262 YNDMVLEQRVIELTKENHVLKAQLDAIRDKFNISGENLVSVEKILASLPTSEQVLSNTKRAKMSG 326
            ...:..:|:|:|...||..|:::::.:.       :.|.::..:...:|.:..::        .|
Human   227 RRILETQQKVLEYMAENERLRSRVEQLT-------QELDTLRNLFRQIPEAANLI--------KG 276

  Fly   327 SGGSS 331
            .||.|
Human   277 VGGCS 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vri	NP_001137792.1	bZIP_NFIL3	238..297	CDD:269842	16/58 (28%)
vri	NP_001137792.1	coiled coil	239..297	CDD:269842	16/57 (28%)
CEBPE	NP_001796.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		PHA03247	<62..192	CDD:223021	29/147 (20%)
		bZIP_CEBPE	202..262	CDD:269863	18/66 (27%)
		coiled coil	207..258	CDD:269863	16/57 (28%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	208..228		9/19 (47%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	230..237		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810