DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vri and CEBPB

DIOPT Version :9

Sequence 1:	NP_001137792.1	Gene:	vri / 33759	FlyBaseID:	FBgn0016076	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_005185.2	Gene:	CEBPB / 1051	HGNCID:	1834	Length:	345	Species:	Homo sapiens

Alignment Length:	306	Identity:	65/306 - (21%)
Similarity:	108/306 - (35%)	Gaps:	93/306 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GPRPPTG-----GKEEKLLLLAP-------PGKLYPEASVST--AMPEVLSGTPTNS---HNKAN 136
            |||||.|     |..|:.:..:|       |....|..:..|  |.|...:..|.:|   |:..:
Human    55 GPRPPAGELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAPAPASSGQHHDFLS 119

  Fly   137 IAMMNNVRLSNISP-------TLSMNGSSNEASNLHPLSMYGGSISP------------------ 176
            ....::....|...       :|...|::..|  |||     |..:|
Human   120 DLFSDDYGGKNCKKPAEYGYVSLGRLGAAKGA--LHP-----GCFAPLHPPPPPPPPPAELKAEP 177

  Fly   177 --QSNDSGMSDSLGKYVPGSGYG----------------------DGMMAQSPSQGGNG------ 211
              :..|....:..|  .||.|.|                      .|.::.|.|....|
Human   178 GFEPADCKRKEEAG--APGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPAD 240

  Fly   212 ---PQSALTAAQKELFSQRKQREFTPDNKKDESYWDRRRRNNEAAKRSREKRRYNDMVLEQRVIE 273
               |.:|..|......||.|.:.....:|..:.|..||.|||.|.::||:|.:..::..:.:|:|
Human   241 AKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLE 305

  Fly   274 LTKENHVLKAQLDAIRDKFNISGENLVSVEKILASLPTSEQVLSNT 319
            ||.||..|:.:::.:       ...|.::..:...||  |.:|:::
Human   306 LTAENERLQKKVEQL-------SRELSTLRNLFKQLP--EPLLASS 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vri	NP_001137792.1	bZIP_NFIL3	238..297	CDD:269842	17/58 (29%)
vri	NP_001137792.1	coiled coil	239..297	CDD:269842	17/57 (30%)
CEBPB	NP_005185.2	Required for Lys-174 sumoylation	1..24
		Required for MYC transcriptional repression. /evidence=ECO:0000250\|UniProtKB:P28033	24..135		18/79 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..67		6/11 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..116		7/36 (19%)
		9aaTAD	116..124		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..178		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..271		11/52 (21%)
		bZIP_CEBPB	264..334	CDD:269860	19/76 (25%)
		coiled coil	271..332	CDD:269860	18/67 (27%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	275..295		9/19 (47%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	297..304		0/6 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810