Protein Alignment Bub1 and bub1

DIOPT Version :10

• Sequence 1: NP_608919.1
• Gene: Bub1 / 33758
• FlyBaseID: FBgn0031696
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: NP_001072830.1
• Gene: bub1 / 780291
• XenbaseID: XB-GENE-974762
• Length: 1122
• Species: Xenopus tropicalis
• Alignment Length: 1241
• Identity: 269/1241 - (21%)
• Similarity: 432/1241 - (34%)
• Gaps: 394/1241 - (31%)

  Fly    41 QAWEHAISLYQGPDPLDHWYNYICWYENHAQSDPELKYRETLERCLTVYEHNDYYRQDVRLVRLW 105
            |.:|..|..|:|.||||.|..|:.|.|.......:......|||.:..:..:..|..|.|.::..
 Frog     8 QMFEAHIQGYKGDDPLDLWERYVLWAEETLPPQEKQNIFCLLERLVRNFIGDKRYSNDERYLKYC 72

  Fly   106 LKYIAMQTDPLHFYQVLFQRGTGRQVAAFYIGWAAYYESREEYKDAEAVFNLAFQEKAQSTSELQ 170
            :::.....:|..:::.|:.:|.|.|.|..|:.||...|::.:.:.|..::..|....|:....|.
 Frog    73 IRFAETINEPAQYFEYLYNQGIGHQSAPLYVTWAQLLETQGDLQGASTLYQKAIHSHAKPKEILD 137

  Fly   171 HAHTKFAYARSLFYQRQQQQQQQQQQH-------------------------------------Q 198
            .....|....|         |...|.|                                     |
 Frog   138 QHFRAFQIRVS---------QANMQNHGALVEPLRNSQILNQMNSTSSNVDQLSLAKCESSAPSQ 193

  Fly   199 QHPPQDA------------------------------LQQLTNYAQQQMPQSYNQHRPQPYQQNV 233
            .|..|::                              ::|:..|.:.::..|.::...:.::.|:
 Frog   194 IHTSQESACDVDRSGNKWVTISKSAVVPQPAKSVGVEVKQVPMYCKDKLVCSDSELSFEEFRANI 258

  Fly   234 Y----------QQYHPQAQAHQAPQPHQPAPQQQLPPE-------------QQVPYQTHYQERPR 275
            |          ||:..:.:.::..:......:|.|..:             |.|..|:..::.|.
 Frog   259 YKKKCEQRKKMQQWEEEERKYKKVKEEASLQEQLLKQKMEQLSSLLNVQGRQDVLPQSTARQLPE 323

  Fly   276 YE------------------PHPATQS------PTAIPPSQVQQQS--HYAPVAESHYAPA-QQS 313
            ..                  |...||:      |..:|.|.|...|  ..||...:..:|| ::.
 Frog   324 VPQTITSNVSIASGLKISNLPEAETQASSVKDDPIILPSSHVACPSVPQMAPFGRNECSPAPEEC 388

  Fly   314 QLPPQQ---------TTVPQLH-AQQ---PQQQQNGNGNPP-----PQQSPPVTNEVAGLRL--- 357
            .|||..         :.||:.| |:|   .:||.|.:.:..     .:|..|.|: ..|||.
 Frog   389 MLPPMDQNSILCKAASNVPRAHIAEQSILSKQQSNLDRSTATVLEMSKQICPDTS-TQGLRFQPG 452

  Fly   358 ------PRNFHAYGRN-NHETWKPALTLEEPDDPSRVCHYAKQLVYPPGAGVEYSPEEILARKFK 415
                  |.|...|..| :|.|...:|.|                       |:.:|.::|
 Frog   453 KKEAAAPGNLSGYLANTSHVTPNTSLGL-----------------------VQATPSKVL----- 489

  Fly   416 QLMDQKAKPSEPPEQEQQTLYDSYETEKSYYMTAVDGALYGQNTSSGQENTGEEDEDNDAEEGEE 480
                  ..|:...::....:.|.::                  ||:..:|..||:|..|
 Frog   490 ------PSPTVNTKEALGFIMDIFQ------------------TSTLPDNVEEEEETQD------ 524

  Fly   481 EEDGGEENEEDDSDEEEEDDEEEEEHSGPYTNGVQFSAQTTFEQENRSIKIKFRKEPSSTYSAYT 545
                            |.|.|.|......|                        |..|:|.....
 Frog   525 ----------------ENDQEFEAFCRNDY------------------------KTNSNTVGFLG 549

  Fly   546 IENVYQQQQQQQQEQHQIIHQPPQAVHHPSPDPAPASPIPIQRQRNGSHHHFHPYMLGQTSTPKS 610
            ::||                             |||.|              ..:.:.:.:..|
 Frog   550 LQNV-----------------------------APALP--------------SAFCIFEDNVNK- 570

  Fly   611 EANGYRRARTKVK----RSKFQPDLCSNS--NSASSVAD------VASSSVLAGAPGTFNDNANF 663
             .|..:....:||    |...:|.|.||.  .:|.|:.|      |..:..||.:|   |...:|
 Frog   571 -VNDLQSKPVEVKTLRERPVLRPPLKSNEEVKAAESLVDDCTVWAVRCNKTLAPSP---NSTGDF 631

  Fly   664 SFSSATALDNSN----SSLALAVDRLN------------FRD-----TSQQQILHPVNKTLQIHN 707
            :.::..|...:|    |:.....|:.|            |.:     .|:.:.|.|:.:....|:
 Frog   632 ALAARLASTPANKQTESTWQTVEDKENVIADSVVHTVFDFAEDKVIQVSKSRKLSPIQEQSPEHS 696

  Fly   708 NNNNTSNNNNGT-----STMADF--------------------------STFQENSYFATQ---- 737
            ..:....:.:.|     |..|.|                          .:.::.....||
 Frog   697 KIHGPVQSPSCTILPAESPAAKFLSEDVEQTGQKLAACKLSDTLHQPVLGSLEDPWGITTQMLDA 761

  Fly   738 HDTEAQERRLSKAVE--TIARHMDKEAIDPFNSELCRAFLAKLDFPGNHDAHASYKIVQTPLPKI 800
            |:.|..|..::...|  .|....|.:.||...|||          |.:..:|.:|....|.:|.:
 Frog   762 HEEEPTETIVNAPPELVIIENAWDDKLIDRLLSEL----------PKSLSSHENYYQWHTMVPVL 816

  Fly   801 SNTRTLNVLEGVTFSIDKEVGRGSYGSVYKATDSRTGN-VVALKYQKPPNTWEIYICDQVLKRIK 864
            .....:. |...:|.||..:|.|::.:||:|  |..|| .|.||.|||...||.||..|:.:|||
 Frog   817 KPKMEVK-LGSSSFYIDYLLGEGAFANVYQA--SLLGNQKVILKVQKPAKPWEFYIGTQIRERIK 878

  Fly   865 EPEVLPGVMDISTAIIAPNASLIATEFSPFGSLLDINNKIRQATTKVMHESLVMHFSAQICNIVD 929
             ||:....:....|.:..|.|::..:...:||||:..|..::.:.|||...|||:|:..|..:|:
 Frog   879 -PELRHLFIGFQAAHLFDNGSVLVGDLYNYGSLLNAINLYKKLSEKVMPAPLVMYFAINILYMVE 942

  Fly   930 HLHRQHIIHADIKPDN------FLLMRVPNVDSPLPSLRLIDFGCAIDMTLFPDGEKTKFRKVVQ 988
            .||...|||.||||||      ||.....::|.....|.|||.|.:|||||||.|  |.|....:
 Frog   943 QLHDIGIIHGDIKPDNFAIGERFLENESCSLDFVSHGLALIDLGQSIDMTLFPKG--TAFTGKCE 1005

  Fly   989 TDGFTCIEMQEGRSWSYETDLFCIAATVHVMLFGDYMQPQKKGSSWEIRQKLPRYLKKHVWTKFF 1053
            |..|.|.||...:.|:|:||.|.:|.||:.|:||:||:.:.:...|:......||....||.:||
 Frog  1006 TSCFQCTEMLTKKPWNYQTDYFGVAGTVYCMMFGNYMKVKNEQGVWKPDGTFKRYQHGGVWMEFF 1070

  Fly  1054 GDLLNM 1059
            ..|||:
 Frog  1071 HTLLNV 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bub1	NP_608919.1	Mad3_BUB1_I	38..158	CDD:214817	30/116 (26%)
		STKc_Bub1_BubR1	813..1096	CDD:270883	101/254 (40%)
bub1	NP_001072830.1	Mad3_BUB1_I	8..125	CDD:214817	30/116 (26%)
		STKc_Bub1_vert	828..1110	CDD:270930	101/254 (40%)