DRSC/TRiP Functional Genomics Resources

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Protein Alignment Bub1 and BUB1B

DIOPT Version :9

Sequence 1:NP_001285621.1 Gene:Bub1 / 33758 FlyBaseID:FBgn0031696 Length:1099 Species:Drosophila melanogaster
Sequence 2:NP_001202.5 Gene:BUB1B / 701 HGNCID:1149 Length:1050 Species:Homo sapiens


Alignment Length:1213 Identity:255/1213 - (21%)
Similarity:429/1213 - (35%) Gaps:399/1213 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 KQAWEHAISLYQGPDPLDHWYNYICWYE-NHAQSDPELKYRETLERCLTVYEHNDYYRQDVRLVR 103
            |:|:|:.|..|.|.||||.|..||.|.| |:.|...|......|||.:...:....|..|.|.:.
Human    59 KRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLN 123

  Fly   104 LWLKYIAMQTDPLHFYQVLFQRGTGRQVAAFYIGWAAYYESREEYKDAEAVFNLAFQEKAQSTSE 168
            ||||...:..:||..|..|..:|.|..:|.|||.||..||:||.::.|:|:|....|:||:....
Human   124 LWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLER 188

  Fly   169 LQHAHTKFAYARSLFYQRQ-----QQQQQQQQQHQQHPPQDALQQLTNYAQQ--QMP-------- 218
            ||..|.:| .||   ..||     :::::::......|.:..|.:|.:..::  :.|        
Human   189 LQSQHRQF-QAR---VSRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGAL 249

  Fly   219 QSYNQHR------PQPYQQN----VYQQYHPQAQAHQAPQPH-QP--APQQQLPPEQQV---PYQ 267
            ::.:|:|      ||..|.|    |:.:...:|...:..:|. ||  ||......|.::   |:.
Human   250 KAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWN 314

  Fly   268 T--HYQERPRYEPHPATQSPTAIP---PSQVQQQSHYAPVAESHYAPAQQSQLPPQQTTVPQLHA 327
            |  ..:.|||..    |.|..|:|   ||       :.|..|.                    .|
Human   315 TGRSLEHRPRGN----TASLIAVPAVLPS-------FTPYVEE--------------------TA 348

  Fly   328 QQPQQQQNGNGNPPPQQSPPVTNEVAGLRLPRNFHAYGRNNHETWKPALTLEEPDDPSRV-CH-- 389
            :||..        .|.:..|..|.:...|.|      |:            ||.|...|| .|  
Human   349 RQPVM--------TPCKIEPSINHILSTRKP------GK------------EEGDPLQRVQSHQQ 387

  Fly   390 ----------YAKQLVYPPGAGV-EYSPEEILARKFKQLMDQKAKPSEPPEQEQQTLYDSYETEK 443
                      |.|:.:|   ||| |:|.|||.|..|:    :|.|     ||.:..|..|.|.. 
Human   388 ASEEKKEKMMYCKEKIY---AGVGEFSFEEIRAEVFR----KKLK-----EQREAELLTSAEKR- 439

  Fly   444 SYYMTAVDGALYGQNTSSGQENTGEEDEDNDAEEGEEEEDGGEENEEDDSDEEEEDDEEEEEHSG 508
                                           ||..::.|:..::.:|..:.::|...:::||   
Human   440 -------------------------------AEMQKQIEEMEKKLKEIQTTQQERTGDQQEE--- 470

  Fly   509 PYTNGVQFSAQTTFEQENRSIKIKFRKEPSSTYSAYT------------IENVYQQQQQQQQEQH 561
                     ...|.|.....|..:.:|.|..|.|:..            .||::|:|...:    
Human   471 ---------TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSK---- 522

  Fly   562 QIIHQPPQAVHHPSPDPAPASPIPIQRQRNGSHHHFHPYMLGQTSTPKSEAN-----GYRRARTK 621
                             .|:.|..|          |..::|.:.......|:     ..||....
Human   523 -----------------GPSVPFSI----------FDEFLLSEKKNKSPPADPPRVLAQRRPLAV 560

  Fly   622 VKRSK-------FQPDLCSNSNSASSVADVASSSVLAG------APGTFNDNANFS--------- 664
            :|.|:       ..||:|   :..:.:..::..:::.|      .|.. .|..:|:         
Human   561 LKTSESITSNEDVSPDVC---DEFTGIEPLSEDAIITGFRNVTICPNP-EDTCDFARAARFVSTP 621

  Fly   665 FSSATALDN--SNSSLALAVDRLNFRDTSQQQI--------------LHPVNKTLQIHNNNNNTS 713
            |....:|.:  |:....|..:.|:.:.:..||.              |.|:.:..:...:::..|
Human   622 FHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFS 686

  Fly   714 NNNNGTSTMADFSTFQ---------ENSYFATQHDTEAQERR-LSKAVETIARHMDKEAIDPFNS 768
            .::...::.:.....|         |.|...||....:|.|| |.|::..::.          ::
Human   687 GSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSA----------SA 741

  Fly   769 ELCRAFLAKLDFPGNHDAHASYKIVQTPLPKISNTRTLNVLEGVTFSIDKEVGRGSYG------- 826
            |||                    |...|:||:              .|:||:..|:..       
Human   742 ELC--------------------IEDRPMPKL--------------EIEKEIELGNEDYCIKREY 772

  Fly   827 ------SVYKATDSRTGNVVALKYQKPPNTWEIYICDQVLKRIKEPEVLPGVMDISTAIIAPNAS 885
                  .::......:..:..:|....|..|:.||..::.:|:.|                    
Human   773 LICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNE-------------------- 817

  Fly   886 LIATEFSPFGSLLD-----------IN----NKIRQATTKVMHESLVMHFSAQICNIVDHLHRQH 935
                :|..|.|...           ||    ..:.|.:..:.||..|: ....:..||:.||:..
Human   818 ----DFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITHEITVL-IIYNLLTIVEMLHKAE 877

  Fly   936 IIHADIKPDNFLLMRVPNVDSPL------PSLRLIDFGCAIDMTLFPDGEKTKFRKVVQTDGFTC 994
            |:|.|:.|...:|..  .:..|.      .:|:::||..::|:.:..|        |....||..
Human   878 IVHGDLSPRCLILRN--RIHDPYDCNKNNQALKIVDFSYSVDLRVQLD--------VFTLSGFRT 932

  Fly   995 IEMQEGR------SWSYETDLFCIAATVHVMLFGDYMQPQKKGSSWEIRQKLPRYLKKHVWTKFF 1053
            :::.||:      |..|:.|||.||...|::||.:::|....||.|::.|.:.......:|.|||
Human   933 VQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFF 997

  Fly  1054 GDLLNMQAD-------KLPALHEMRLIFEEEAYRMDSELQKQI 1089
            ..:||...:       :|.|  ||..:|:.   ...|.|.|.:
Human   998 VRILNANDEATVSVLGELAA--EMNGVFDT---TFQSHLNKAL 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Bub1NP_001285621.1 Mad3_BUB1_I 38..158 CDD:214817 47/118 (40%)
STKc_Bub1_BubR1 813..1096 CDD:270883 69/324 (21%)
BUB1BNP_001202.5 Mad3_BUB1_I 57..178 CDD:400553 47/118 (40%)
Nuclear localization signal. /evidence=ECO:0000255 111..118 1/6 (17%)
Necessary for interaction with KNL1. /evidence=ECO:0000269|PubMed:17981135 152..185 16/32 (50%)
D-box 224..232 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..393 9/42 (21%)
PTZ00121 <369..>488 CDD:173412 39/192 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 456..480 5/35 (14%)
STKc_BubR1_vert 750..1045 CDD:270931 71/340 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141956
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1166
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1411806at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14030
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

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