DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bub1 and bub-1

DIOPT Version :9

Sequence 1:	NP_001285621.1	Gene:	Bub1 / 33758	FlyBaseID:	FBgn0031696	Length:	1099	Species:	Drosophila melanogaster
Sequence 2:	NP_492051.1	Gene:	bub-1 / 172468	WormBaseID:	WBGene00000275	Length:	987	Species:	Caenorhabditis elegans

Alignment Length:	815	Identity:	174/815 - (21%)
Similarity:	288/815 - (35%)	Gaps:	225/815 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 QQSPPVTNEVAGLRLPR-------------NFHAYGRNNHE--TWKPALTLEEPDDPSRVCHYAK 392
            |.:.|:.|.......|:             |:|........  .||.....:..||      |.|
Worm   185 QHNVPINNSGKAAFGPKTKTDLRQACIDRPNYHGISIEEFRFAKWKDTFGEDVDDD------YRK 243

  Fly   393 QLVYPPGAGVEYSPEEIL--ARKFKQLMDQKAKPSEPPEQ------EQQTLYDSYETEKSYYMTA 449
            :    ..:||.:...:::  .|:.::.::.:...:..|.:      .::|:.|..|.....|...
Worm   244 R----KDSGVVFVKHQVIDTDRQAREEVENRFNANLNPRRRHLSPVSEKTVDDEEEKRSRIYSPL 304

  Fly   450 VDGALYGQNTSSGQENTGEEDEDNDAEEGEEEEDGGEENEEDDSDEEEEDDEEEEEHSGPYTNGV 514
            |       .|............:|.........|....:|:|.||.::.||:|..:        :
Worm   305 V-------ATKDAHRPALRSKIENPPATVTLSSDTKSASEKDVSDSDDADDDERLK--------I 354

  Fly   515 QFSAQTTFEQENRSIKIKFRKEPSSTYSAYTIENVYQQQQQQQQEQHQIIHQPPQAVHHPSP--- 576
            ..:.:......:||..|......:|..::.:...:....:.:..|.|.:.   ...||..|.
Worm   355 MTAGRKDGNPPDRSTSISSNYSTASARTSKSGAGLDLMAENKCLEAHAMF---SDTVHLASEKTM 416

  Fly   577 ---------------------------DPAPASPIPIQRQRNGSHHHFHPYMLGQTSTPKSEANG 614
                                       ||.|...|..:|                   ||..:||
Worm   417 VLGDDSVFVPERSLATTQIVTDFSVLCDPDPTMTITQER-------------------PKKVSNG 462

  Fly   615 ----YRRA-----RTKVKRSKFQPDLCSNSNSASSVADVASSSVLAGAPGT-----FNDNANFSF 665
                |..|     ..||:.|:.||::            |..|.|...:|.|     ::|...|.|
Worm   463 LNVVYDEAAEPEESQKVEESEVQPEI------------VLVSPVTQTSPATMFNDIYDDEIEFGF 515

  Fly   666 SSATALDNSNSSLALAVDRLNFRDTSQQQILHPVNKTLQIHNNNNNTSNNNNG----TSTMADFS 726
            ...:              |.||..::..|.:|.||......|....:::....    ..|.:.||
Worm   516 FKPS--------------RGNFVTSTPAQGVHLVNIDEYFGNKEEESTHEQEAPVFVAPTSSTFS 566

  Fly   727 TFQENSYFATQHD-----TEAQE-------------------RRLSKAVETIARHMDKEA----- 762
            ........|....     ||:.:                   ||||...:.|....:...
Worm   567 KLTRRKSLAANQAVQPSVTESSKPERSDPKDSSIDCLTANLGRRLSIGADEIPNLTENNESEITG 631

  Fly   763 --------------IDPFNSELCRAFLAKLDFPGN-HDAHASYKIVQTPLPKISNTRTLNVLEGV 812
                          |:|::..|.:..:..:..|.| |:       .|...|||...|...| .|.
Worm   632 CKIRRRSEIIKQGDINPWDETLRKKLMCLVRPPQNMHE-------FQERAPKIQALRDCEV-SGE 688

  Fly   813 TFSIDKEVGRGSYGSVYKAT--DSRTGNVVALKYQKPPNTWEIYICDQVLKRIKEP--EVLPG-- 871
            ...|...:|:|.|..||:|.  |.||   ||:||:.|..:||:|||||:..|:|:.  |::..
Worm   689 KLHIQTLIGQGGYAKVYRAVTDDQRT---VAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKCC 750

  Fly   872 VMDISTAIIAPNASLIATEFSPFGSLLDINNKIRQATTKVMHESLVMHFSAQICNIVDHLHRQHI 936
            :|::..|.:...|||:..::..:|:||:..|.::.....:     ......|:..:|..:|...|
Worm   751 IMEVMDAYVYSTASLLVNQYHEYGTLLEYANNMKDPNWHI-----TCFLITQMARVVKEVHASKI 810

  Fly   937 IHADIKPDNFLLMRVPNVD-----SPLPS-----LRLIDFGCAIDMTLFPDGEKTKFRKVVQTDG 991
            ||.|||||||::.|  .:|     ..|.|     :::||:|.||||...   :..:|:....|:.
Worm   811 IHGDIKPDNFMITR--KIDDKWGKDALMSNDSFVIKIIDWGRAIDMMPL---KNQRFKGRAGTEA 870

  Fly   992 FTCIEMQEGRSWSYETDLFCIAATVHVMLFGDYMQ 1026
            |.|.||.:||||:|:.|.|..|||:.|::.|.|.|
Worm   871 FDCPEMVDGRSWTYQADYFGFAATMAVVVAGKYAQ 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bub1	NP_001285621.1	Mad3_BUB1_I	38..158	CDD:214817
Bub1	NP_001285621.1	STKc_Bub1_BubR1	813..1096	CDD:270883	78/230 (34%)
bub-1	NP_492051.1	STKc_Bub1_BubR1	689..980	CDD:270883	78/230 (34%)
bub-1	NP_492051.1	Pkinase	690..939	CDD:278497	78/229 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157562
Domainoid	1	1.000	123	1.000	Domainoid score	I3453
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004065
OrthoInspector	1	1.000	-	-		otm14529
orthoMCL	1	0.900	-	-		OOG6_103677
Panther	1	1.100	-	-	LDO	PTHR14030
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.790