Protein Alignment Bub1 and Bub1b

DIOPT Version :9

• Sequence 1: NP_001285621.1
• Gene: Bub1 / 33758
• FlyBaseID: FBgn0031696
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_006498685.1
• Gene: Bub1b / 12236
• MGIID: 1333889
• Length: 1053
• Species: Mus musculus
• Alignment Length: 1150
• Identity: 248/1150 - (21%)
• Similarity: 414/1150 - (36%)
• Gaps: 331/1150 - (28%)

  Fly    40 KQAWEHAISLYQGPDPLDHWYNYICWYE-NHAQSDPELKYRETLERCLTVYEHNDYYRQDVRLVR 103
            |:|:|..|..|.|.||||.|..||.|.| |:.|...|......:||.:...:....|..|.|.:.
Mouse    53 KRAFESEIRFYSGDDPLDVWDRYINWTEQNYPQGGKESNMSALVERAIEALQGETRYYNDPRFLS 117

  Fly   104 LWLKYIAMQTDPLHFYQVLFQRGTGRQVAAFYIGWAAYYESREEYKDAEAVFNLAFQEKAQSTSE 168
            ||:|...:..:||..|..|..:|.|..:|.|||.||..||:||.:|.|:.:|....:.||:....
Mouse   118 LWIKLGHLCNEPLDMYSYLQSQGIGVSLAQFYISWAEEYEARENFKKADIIFQEGIERKAEPLDR 182

  Fly   169 LQHAHTKF--AYARSLFYQRQQQQQQQQQQHQQHPPQDALQQLTNYAQQ--QMP--------QSY 221
            ||..|.:|  ..:|..|.....::::..:..:  |.:.:|.:|.:..::  :.|        ::.
Mouse   183 LQSQHRQFQSRVSRQAFLALGNEEEEALEPSE--PQRSSLAELKSRGKKMARAPISRVGGALKAP 245

  Fly   222 NQHR------PQPYQQN----VYQQ----------YHPQAQAHQAPQPHQPAPQQQLPPEQQVPY 266
            .|.|      |||...|    |:.:          ..|.||...||    |.|:.:....|..|:
Mouse   246 GQSRGFLNAVPQPVHGNRRITVFDENADTASRTELSKPVAQPWMAP----PVPRAKENELQPGPW 306

  Fly   267 QTHYQERPR-YEPHPATQSPTAIP---PSQVQQQSHYAPVAESHYAPAQQSQLPPQQTTVPQLHA 327
            .|   :||. ..||....|.|:||   ||       :.|..|.   .|||:.:.|.:.
Mouse   307 ST---DRPAGRRPHDNPASVTSIPSVLPS-------FTPYVEE---SAQQTVMTPCKI------- 351

  Fly   328 QQPQQQQNGNGNPPPQQSPPVTNEVAGLRLPRNFHAYGRNNHETWKPALTLEEPDDPSRV----- 387
                              .|..|.|...|.|      ||            ||.|...||
Mouse   352 ------------------EPSINHVLSTRKP------GR------------EEGDPLQRVQSHQQ 380

  Fly   388 -CH-------YAKQLVYPPGAGV-EYSPEEILARKFKQLMDQKAKPSEPPEQEQQTLYDSYETEK 443
             |.       |.|:.:|   ||| |:|.|||.|..|::.:.::        :|.:.|..:.:.|:
Mouse   381 GCEEKKEKMMYCKEKIY---AGVGEFSFEEIRAEVFRKKLKER--------REAELLTSAKKREE 434

  Fly   444 SYYMTAVDGALYGQNTSSGQENTGEEDEDNDAEEGEEEEDGGEENEEDDSDEEEEDDEEEEEHSG 508
            .                  |:...|.:....|.:..::|..|.:.:|:..  ..||....:..||
Mouse   435 M------------------QKQIEEMERRLKAMQAVQQEGAGGQQQEEKM--PTEDPARLQIASG 479

  Fly   509 PY-TNGVQFSAQTTFEQEN-RSIKIKFRKEPSSTYSAYTIENVYQQQQQQQQEQHQIIHQPPQAV 571
            |. .:||..|........| |.|      .|:        ||:.|:|...:..      ..|.::
Mouse   480 PQEMSGVPLSCSICPLSSNPREI------SPA--------ENILQEQPDSKGS------SMPFSI 524

  Fly   572 HHPS----PDPAPASPIPIQRQRNGSHHHFHPYMLGQTSTPKSEANGYRRARTKVKRSK------ 626
            ...|    .|.:||:..|                        ...|..||..:.:|.::
Mouse   525 FDESLSDKKDKSPATGGP------------------------QVLNAQRRPLSVLKTTEVGTTNE 565

  Fly   627 -FQPDLCSNSNSASSVADVASSSVLAG--------APGTFNDNANFSFSSATALDNSNSSLALAV 682
             ..||:|   :..:.:..::..:::.|        .|....|.|..:..::|......||..:|.
Mouse   566 DVSPDIC---DELTELEPLSEDAIITGFRNVTLCPNPEDTCDFARAARLASTPFHEILSSKGIAA 627

  Fly   683 D--------RLNFRDTSQQQILH----------PVNKTLQIHNNNNNTSNNNNGTSTMADFSTFQ 729
            |        .|:.:.......:|          |:.:..:...:::..|.:::...:.:....||
Mouse   628 DPEGLLQEEDLDGKAAEAHHTVHHQALIIKKLSPIIEESREATHSSGFSRSSSSAPSTSSIKGFQ 692

  Fly   730 ENSYFATQHDTEAQERRLSKAVETIARHMDKEAIDPFNSELCRAF-------LAKLDFPGNHDAH 787
                             |.:.:|.    .:..|.|...|..|..:       |.:|      .|.
Mouse   693 -----------------LLEKLEL----TNDGAEDAIQSPWCSQYRLQLLKSLLEL------SAF 730

  Fly   788 ASYKIVQTPLPKISNTRTLNVLEGVTFSIDKEVGRGSYGSVYK-----ATDSR--------TGNV 839
            |.:.:...|:|         |||     |.||:..|....|.|     ..|.|        :..:
Mouse   731 AEFSVEDRPMP---------VLE-----IGKEIELGPEDYVIKQEHLTCDDYRLFWVAPRSSAEL 781

  Fly   840 VALKYQKPPNTWEIYICDQVLKRIKEPEVLPGVMDISTAIIAPNASLIATEFSPFGSLLDINNKI 904
            ..:|....|..|:.||..::.:|:.|     ....:.:.....:..::..::....:|    ..:
Mouse   782 TMIKASSQPIPWDFYINLKLKERLNE-----DYDQLCSCCQYQDGHVVWYQYINCSTL----QNL 837

  Fly   905 RQATTKVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLM-RVPN----VDSPLPSLRLI 964
            .|.:..|.||.:|: ....:..||:.|||..|:|.|:.|.:.:|. |:.:    |:....::|::
Mouse   838 LQHSEFVTHEIIVL-IIYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIHDPYDYVNKDDHAVRIM 901

  Fly   965 DFGCAIDMTLFPDGEKTKFRKVVQTD-----GFTCIEMQEGR------SWSYETDLFCIAATVHV 1018
            ||..::|:.             ||.|     ||...::.||:      |..|..||..||...|:
Mouse   902 DFSYSVDLR-------------VQLDAFAYSGFRTAQILEGQKILANCSSPYHVDLLGIADLAHL 953

  Fly  1019 MLFGDYMQPQKKGSSWEIRQKLPRYLKKHVWTKFFGDLLNMQADK 1063
            :||.:::.....|..|::.|.........:|.|||..:|| .:||
Mouse   954 LLFKEHLHVFWDGLLWKLSQSTSELKDSELWNKFFVRILN-ASDK 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bub1	NP_001285621.1	Mad3_BUB1_I	38..158	CDD:214817	45/118 (38%)
		STKc_Bub1_BubR1	813..1096	CDD:270883	63/279 (23%)
Bub1b	XP_006498685.1	Mad3_BUB1_I	51..172	CDD:369805	45/118 (38%)
		half-pint	<253..445	CDD:130706	62/280 (22%)
		PKc_like	740..1036	CDD:389743	67/295 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14030
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840