Protein Alignment Bub1 and bub1b

DIOPT Version :9

• Sequence 1: NP_001285621.1
• Gene: Bub1 / 33758
• FlyBaseID: FBgn0031696
• Length: 1099
• Species: Drosophila melanogaster
• Sequence 2: XP_031747062.1
• Gene: bub1b / 100125106
• XenbaseID: XB-GENE-1010857
• Length: 1044
• Species: Xenopus tropicalis
• Alignment Length: 1153
• Identity: 249/1153 - (21%)
• Similarity: 419/1153 - (36%)
• Gaps: 304/1153 - (26%)

  Fly    40 KQAWEHAISLYQGPDPLDHWYNYICWYEN-HAQSDPELKYRETLERCLTVYEHNDYYRQDVRLVR 103
            |||:|..:..|.|.||||.|..||.|.|. ..|...|......|||.:.::.....|..|:|.:.
 Frog    46 KQAFELELRFYSGDDPLDVWDRYIKWAEQAFPQGGKESNLCPLLERAVKIFHEEQRYYDDLRYLS 110

  Fly   104 LWLKYIAMQTDPLHFYQVLFQRGTGRQVAAFYIGWAAYYESREEYKDAEAVFNLAFQEKAQSTSE 168
            :.||:....::||..|..|..:..|...|..||.||..:|:|..:|.|:::|....|.||:...:
 Frog   111 ICLKFANFCSEPLDLYSYLHSQRIGVSHALLYITWAEQFEARGNFKKADSIFQQGMQHKAEPLEK 175

  Fly   169 LQHAHTKF-AYARSLFYQRQQQQQQQQQQHQQHPPQDALQQLTNYAQQQMPQSYNQ----HRPQP 228
            |:..|.:| |.......|...:..:.::.....|.:.:|..|.:..:.::....|:    .:|:|
 Frog   176 LEIHHRQFQARVSRQILQGISEGPEAEEPEVPEPQRSSLADLKSRGKNKVKAPINRVGDSIKPRP 240

  Fly   229 YQQNVYQQYHPQAQAHQAPQPHQPAPQQQLPPEQQVPYQTHYQERPRYEPHPATQSP-------- 285
            :..:|                 |.||.||:|...:...         ::.:.|:.:|
 Frog   241 HGLSV-----------------QAAPTQQIPSRSRFAV---------FDENAASAAPELPSLTPQ 279

  Fly   286 --TAIPPSQVQQQSHYA-------PVAESHYAPAQQSQLPPQQTTVPQL--HAQQPQQQQNGNGN 339
              ||.||::.::....|       |...||.|.|...  |||  |:|..  :..:..|||...
 Frog   280 QWTAPPPARSKENEQKAGQWNSGRPSRNSHQAAAASE--PPQ--TLPSFMPYVDESAQQQTVT-- 338

  Fly   340 PPPQQSPPVTNEVAGLRLPRNFHAYGRNNHETWKPALTLEEPDDPSRVCH----------YAKQL 394
             |.:.:|.||:.::                 :.||.   :|.|...||.:          |.|..
 Frog   339 -PCKINPAVTSVLS-----------------SRKPG---KEEDPLQRVQNNSQGKEEKVMYCKDK 382

  Fly   395 VYPPGAGV-EYSPEEILARKFKQLMDQKAKPSEPPEQEQQTLYDSYETEKSYYMTAVDGALYGQN 458
            ||   ||| |:|.|||.|..:      .||..:..|.:.|.:                 ||..|
 Frog   383 VY---AGVEEFSLEEIRAEIY------LAKIRKKREDDLQEI-----------------ALRRQ- 420

  Fly   459 TSSGQENTGEEDEDNDAEEGEEEEDGG-EENEEDDSDEEEEDDEEEEEHSGPYTNGVQFSAQTT- 521
                       :.:...:|.|::..|. .|:||..||:..::.|.........||....::|..
 Frog   421 -----------EMERQIQEMEKQLKGSCIESEEIVSDQPVQNVEPIIAPCNSNTNESLCASQQAP 474

  Fly   522 -------FEQENRSIKIKFRKEPSSTYSAYTIENVYQQQQQQQQEQHQIIHQPPQAVHHPSPDPA 579
                   ||..:               :|.|:         .:.|...:.::.......|...||
 Frog   475 VMEFPHCFEMAD---------------AAPTL---------PRMETLPVFNETGNKPSLPGLSPA 515

  Fly   580 PASPIPIQRQRNGSHHHFHPYMLGQTSTPKSEANGYRRARTKVKRS--KFQPD------------ 630
            .:..:|.......:  ...|.|..|    |..|...||....|.:|  |.|..
 Frog   516 LSCDLPFTIFDESA--EAAPSMTDQ----KRMAAPVRRPLAAVPKSIVKSQESQLTDTLDGTEPL 574

  Fly   631 -----LCSNSNSAS------SVADVASSSVLAGAPGTFNDNANFSFSSATALDNSNSSL---ALA 681
                 :|.:..:.|      ...|...::.||..|  |:          .|.|.|...|   :|.
 Frog   575 NEEAIVCGSGKNKSLFPDPEDTCDFVRAAHLASTP--FH----------RARDQSGECLQSDSLD 627

  Fly   682 VDRLNFRDTS--------QQQILHPVNKTLQIHNNNNNTS----NNNNGTSTMADFSTFQENSYF 734
            ::||..|:.:        |:..:..::..|:....:..||    ::.:.|::|.......|....
 Frog   628 LERLPLREKTPVCEESYRQELCIKKLSPILEASQEDTRTSVSSVSSISSTTSMFTSRPIPEKLEL 692

  Fly   735 ATQ----HDTEAQERRLSKAVETIARHMDKEAIDPFNSELCRAFLAKLDFPGNHDAHASYKIVQT 795
            |||    :::|.....|.:|.|.              :||.|..|..|.           :::.:
 Frog   693 ATQITGVYESEPTTEELPQAEEL--------------AELHRQLLESLP-----------ELLVS 732

  Fly   796 P--------LPKISNTRTLNVLEGVTFSIDKEVGRGSYGSVYKAT----DSRTGNVVALKYQKPP 848
            |        :|.:.....: ||...|:.:..||.......::...    |.......|||....|
 Frog   733 PEIQHEVGTMPDMKEQGEV-VLGCETYGLKNEVILHPNSKLFMGAPVDWDMGDMKAFALKVDYQP 796

  Fly   849 NTWEIYICDQVLKRIKEPEVLPGVMDISTAIIAPNASLI----------ATEFSPFGSLLDINNK 903
            ..|:.|:..|:.:|:       |.:..:..|...|..|.          ...||....|||....
 Frog   797 LPWDFYVTMQLKERL-------GDLFETFFIEQTNCFLYQNGCISLYKDINRFSIQEILLDSEEH 854

  Fly   904 IRQATTKVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLL-MRVPNVDSPLP---SLRLI 964
            |::....|.:..|         ::|:.||...|:|.|::|:..|| .::.::.|.|.   ..:|:
 Frog   855 IKEVIVLVTYNLL---------SLVEKLHSVEIVHGDLRPETLLLDDKIFDLSSSLELKGLFKLV 910

  Fly   965 DFGCAIDMTLFPDGEKTKFRKVVQTDGFTCIEMQEG------RSWSYETDLFCIAATVHVMLFGD 1023
            ||..::|:.|:|.....:        ||...:.:.|      :|..|:.||..||..||:|:|..
 Frog   911 DFSHSVDLKLYPIMSSLR--------GFPIAQTESGQQFLSPQSSPYQVDLLGIADLVHLMIFRK 967

  Fly  1024 YMQPQKKGSSWEIRQKLPRYLKKHVWTKFFGDLLNMQADKLPALHEMR 1071
            .:|..::.|.|.|.:::||....::|.|||..:||.:......|.|::
 Frog   968 PLQLHQENSVWMICKEVPRLRGGNLWNKFFTKILNAEGPSTRVLGELK 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bub1	NP_001285621.1	Mad3_BUB1_I	38..158	CDD:214817	40/118 (34%)
		STKc_Bub1_BubR1	813..1096	CDD:270883	68/283 (24%)
bub1b	XP_031747062.1	Mad3_BUB1_I	44..165	CDD:400553	40/118 (34%)
		MerR-DNA-bind	<390..431	CDD:401278	13/75 (17%)
		PKc_like	742..1044	CDD:419665	71/299 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1411806at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14030
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020