DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yrk and Src42A

DIOPT Version :9

Sequence 1:	NP_001352482.1	Gene:	yrk / 337571	ZFINID:	ZDB-GENE-030131-9517	Length:	528	Species:	Danio rerio
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	245/419 - (58%)
Similarity:	305/419 - (72%)	Gaps:	14/419 - (3%)

- Green bases have known domain annotations that are detailed below.

Zfish   115 SLDTGKSGYIPSNYVAPV---DSIQAEEWYFGKMGRKDAERQLLAQNNPRGTFLIRESETTKGAY 176
            ||.|.|.|  .|..::..   :.:..:.|||.|:.|.:||::||...|..|.||||:||:....|
  Fly  1184 SLTTAKKG--KSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDY 1246

Zfish   177 SLSIRDWDDAKGDHVKHYKIRKLDNGGYYITTRTQFDTVQQLVEHYTERAAGLCCRLIGSC-RRG 240
            |||:||     ||.||||:||:||.||::|..||.|.|:|:|||||::.:.|||..|...| :..
  Fly  1247 SLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIE 1306

Zfish   241 MPKLADLSVKTKDVWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVKTLKPGTMSPEAFLDE 305
            .|....||.:|:|.|||.|.||:.::|||:||||:||.|:||.||.||:||||.|||.|:.||.|
  Fly  1307 KPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAE 1371

Zfish   306 AQIMKRLRHDKLVQLYAVVS-EEPIYIITEFMSQGSLLDFLK--DGDGRNLKLPQLVDMAAQIAA 367
            |||||:|||.||:|||||.: |||||||||.|..||||::|:  .|.||:||:..|:||||||||
  Fly  1372 AQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAA 1436

Zfish   368 GMAYIERMNYIHRDLRAANILVGDGLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 432
            ||||:|..|||||||.|.|:|||||.:.|||||||||||:::||.||.||:|||||||||||.|.
  Fly  1437 GMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYS 1501

Zfish   433 KFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCPQGSPASLHELMLQCWRKD 497
            ||:|||||||||||||||:|.||:|||||.|.|||.|||.|||||.|......|:|:||:||.||
  Fly  1502 KFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKD 1566

Zfish   498 PDERHTFEYLQSFLEDYFTATEPQYQPGE 526
            |..|.|||.||..|||::|:.:..|:..:
  Fly  1567 PMRRPTFETLQWKLEDFYTSDQSDYKEAQ 1595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrk	NP_001352482.1	SH3	76..133	CDD:327375	6/20 (30%)
		SH2	136..234	CDD:326550	49/97 (51%)
		PTKc_Src_Fyn_like	266..513	CDD:271105	173/249 (69%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	50/95 (53%)
		PTKc_Frk_like	1319..1587	CDD:270653	183/267 (69%)
		Pkinase_Tyr	1328..1580	CDD:285015	173/251 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.960