DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg25D and Ninl

DIOPT Version :9

Sequence 1:	NP_001260093.1	Gene:	Bsg25D / 33757	FlyBaseID:	FBgn0000228	Length:	1118	Species:	Drosophila melanogaster
Sequence 2:	XP_006500469.1	Gene:	Ninl / 78177	MGIID:	1925427	Length:	1400	Species:	Mus musculus

Alignment Length:	1459	Identity:	327/1459 - (22%)
Similarity:	517/1459 - (35%)	Gaps:	476/1459 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YEQKLYQMFRSCETQ-CGLLDEKSLLKLCSLLELRDQGSALIASLGGSHQLG-VSFGQFKEALLN 70
            |..:|..::.||:|. .|.||::.|.:||:.|.|.:|..||:..|.|..:|. |:|.:|||..:.
Mouse    15 YVSRLRDVYSSCDTTGTGFLDQEELTQLCTKLGLEEQLPALLHILLGDDRLARVNFEEFKEGFVA 79

  Fly    71 FLGSEFDGNTSSGFIERSLVITDEPLNNTYIESPPESSDRE------VSPKLVVGTKKYGRRSRP 129
            .|.|      .||.         ||       |..|.|..|      |.||.:.|:|.|||||.|
Mouse    80 VLSS------GSGV---------EP-------SDEEGSSSESATSCAVPPKYMSGSKWYGRRSLP 122

  Fly   130 QQGIYELSVTDSDNTDEDQLQQQ---------QNQRSLNGCDELGVQVQRSSS---QSDL---PG 179
            :.|       ||....:...:||         :...||...:.|.......|:   |::|   .|
Mouse   123 ELG-------DSATATKYGSEQQAKGSVKPPLRRSASLESVESLKSDEDAESAKEPQNELFEAQG 180

  Fly   180 SRRLRSVHTSGSKLKRCA---SLPAR------RKMNSNTTGATTSPTAAAKLKQLSIQS-QAQHS 234
            ..|.......|:..|.|:   |.|..      .::...::|.......|...:.:.:.| :.|..
Mouse   181 QLRSWGCEVFGTLRKSCSPSFSTPENLVQGIWHELGIGSSGHLNEQELAVVCRSIGLHSLEKQEL 245

  Fly   235 SSVES-------------------LGHRLATNPAPSS-----EHWRCYHGGRWSCCKDTVTPQQL 275
            ..:.|                   .||...:.||.||     ..|..|.  ..|.|..|.|...:
Mouse   246 EELFSKLDQDGDGRVSLAEFQLGLFGHEPPSLPASSSLIKPNRLWSHYQ--EESGCHTTTTSSLV 308

  Fly   276 ETIS----------------VHSIMEAWELASIPNTRNLLHVLGFDEEEEVNLQQLTKALEEELR 324
            ...|                ...::.||....|.|.|.:|..|.|..:|:|||.:||.||:.||.
Mouse   309 SVCSGLRLFSSVDDGSGFAFPEQVISAWAQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELL 373

  Fly   325 GIDGDHEQSNMLRALAALQATELGNYR--LAYRQQHEENL-----KLRADNKAANQRVALLAVEV 382
            .:||            .:|...|..||  |:|.|...:.|     |.|.|.:.|.:|......|:
Mouse   374 TVDG------------VIQQAALACYRQELSYHQGQVDQLVQERDKARQDLEKAEKRNLDFVREM 426

  Fly   383 DERHASLEDNSKKQVQQLEQRHASMVREITLRMTNDRD-HWTS---MTGKLEAQLKSLEQEEIRL 443
            |:.|::||..::|:::.|||.:...:..:...:..:|: .|..   ....||..:..|:.||..|
Mouse   427 DDCHSALEQLTEKKIKHLEQEYRGRLSLLRSEVEMERELFWEQARRQRAVLEQDVGRLQAEETSL 491

  Fly   444 RTELELVRTENTELESEQQKAHIQITELLEQNIKLNQELAQTSSSIGGTPEHSPLRPRRHSEDKE 508
            |.:|.|...||:.|    ||..|::.|.|..:.||...|......:        |:.:  .|.:.
Mouse   492 REKLTLALKENSRL----QKEIIEVVEKLSDSEKLVLRLQSDLQFV--------LKDK--LEPQS 542

  Fly   509 EEMLQLMEKLAAL----QMENAQLRDKTDELTIEIESLNVELIRSKTKAKKQEKQEKQEDQESAA 569
            .|:|...|:..|:    :::...|:|:.|||..|:|.|.:.|.||:              |..|.
Mouse   543 MELLAQEEQFTAILNDYELKCRDLQDRNDELQAELEGLRLRLPRSR--------------QSPAG 593

  Fly   570 T-ATKRRGDSPSKTHLTEESPRLGKQRKCTEGEQSDASNSGDWLALNSELQRSQSQD--EEL-TS 630
            | .|.||           ..|..|.......||.:..|       |.:|:...|.::  :|| ..
Mouse   594 TPGTHRR-----------RIPGRGPADNLFVGESTPVS-------LETEIMVEQMKEHYQELRMQ 640

  Fly   631 LRQRVAELEEELKAAKEGRSLTPESRSKE----LETSLEQMQRA----------------YEDCE 675
            |..:|...|:|::..|  |:...:.:..|    ||.|:.:.|:|                .|..:
Mouse   641 LETKVNYYEKEIEVMK--RNFEKDKKEMEQAFQLEVSVLEGQKADLEALYAKSQEVILGLKEQLQ 703

  Fly   676 DYWQT---------------------KLSEERQLFEKER--QIYEDEQHESDKKFTEL------- 710
            |..|:                     :|..|..|..:::  ||.::.:.|.::|.:.|
Mouse   704 DAAQSPEPAPAGLAHCCAQALCTLAQRLEVEMHLRHQDQLLQIRQEAEEELNQKLSWLEAQHAAC 768

  Fly   711 MEKVREYEEQFSKDGRL-----------SPID-ERDMLEQQYSELEAEA--AQLRSSSIQMLEEK 761
            .|.: ..:.|..||..|           :.:| |:...|::..|:.|..  .||:..:: |.||:
Mouse   769 CESL-SLQHQCEKDQLLQTHLQRVKDLAAQLDLEKGRREEREQEVLAHCRRQQLKLQAV-MSEEQ 831

  Fly   762 AQEISSLQSEIEDLRQRLGESVEILTGACE----LTSESVAQLSAEAGKSPASSPISYLWLQSTI 822
            |:...|...|.|.|.|...|.||.|....:    |.......:|.:..::|:|..:.    ..:.
Mouse   832 ARICRSFTLEKEKLEQTYREQVEGLVQEADVLRALLKNGTTVVSDQQERTPSSMSLG----PDSR 892

  Fly   823 QEPAKSLADSKDEATASAIE----------------------------LLGGSPSHKTASRNN-- 857
            |:|....|.|.|..|.:..|                            ||....|.....|:|
Mouse   893 QQPTARQAVSPDGRTGAPAEWPGPEKAEGRDFPGQLCSIDAMPSPTPTLLSRRSSENLGVRDNHQ 957

  Fly   858 --LTTSETSI------------------------------FSTTPFE----------SSQSGPSP 880
              |...|.:|                              ..||..:          .:..||..
Mouse   958 RPLNAEEGAIPKEPEPSARTLTGQGQKLPLPVHPQMLEPSLGTTALDRKAASVGVQGQASEGPVG 1022

  Fly   881 TNSGNSNAYGANPGPAPISKP----KRSQSPQQA----AASEGEIAD------------------ 919
            ...|...|:....|.|...:|    ....:||:|    |.||.|:.|
Mouse  1023 DGEGVQEAWLQFRGEATRMRPSLPCSELPNPQEATVMPAMSESEMKDVKIKLLQLEDVVRALEKA 1087

  Fly   920 ------------------------------CETS----------------------------STA 926
                                          .|||                            ||.
Mouse  1088 DSRESYRAELQRLSEENLVLKSDLGKIQLELETSESKNEVQRQEIEVLKRDKEQACCDLEELSTQ 1152

  Fly   927 SGKSFESNSKTSCLSHEKCSSPSAL---KEE--------LKRLKFFELSLKE-----QIKDLSLQ 975
            :.|..:..|:.:|...:....||.|   |||        :|:|:  |...:|     ||::|.::
Mouse  1153 TQKYKDEMSQLNCRVLQLEGEPSGLHTQKEENHGAIQVLMKKLE--EAGCREEQQGDQIQNLKIE 1215

  Fly   976 RDGLVMELQ-----------QLQEARPVLEKAY-----ARTTH----PTLQQRLNQL-------E 1013
            .:.:..|.|           .|:|:|..|....     |::.|    ..||::::||       |
Mouse  1216 LERVNEECQYLRLSQAELTESLEESRSQLYSVQLRLEAAQSQHGRIVQRLQEQMSQLVPGARVAE 1280

  Fly  1014 LRNRHLQNVIKQQQHYTESLMQQSWRQH------QVELNDLHSRIETQGVLLADQTQRLQS---- 1068
            |  :||.|| |:::....|..|:.:||.      |||  |..:|:.....||.::.:.|:.
Mouse  1281 L--QHLLNV-KEEEARRLSAQQEEYRQQLKAREDQVE--DAEARLRNVEWLLQEKVEELRKQFEK 1340

  Fly  1069 ---ADILVKDLYVENSHLTATVQRLEQQR 1094
               :|:|:|:|||||:||...||..|:::
Mouse  1341 NTRSDLLLKELYVENAHLMKAVQLTEEKQ 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg25D	NP_001260093.1	SMC_prok_B	<306..545	CDD:274008	70/253 (28%)
		Smc	<428..777	CDD:224117	96/420 (23%)
		Spc7_N	<769..937	CDD:292045	51/327 (16%)
		GAS	951..>1053	CDD:290562	39/150 (26%)
Ninl	XP_006500469.1	EF-hand_7	17..77	CDD:372618	23/59 (39%)
		EF-hand_7	205..266	CDD:372618	5/60 (8%)
		PRK13589	305..>363	CDD:172158	13/57 (23%)
		Smc	<405..768	CDD:224117	92/410 (22%)
		Smc	622..>1392	CDD:224117	153/763 (20%)
		SMC_prok_B	<1085..1395	CDD:274008	65/292 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838275
Domainoid	1	1.000	96	1.000	Domainoid score	I7319
eggNOG	1	0.900	-	-		E1_28W3C
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4859
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003212
OrthoInspector	1	1.000	-	-		otm44302
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18905
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8624
SonicParanoid	1	1.000	-	-		X6308
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.970