DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg25D and nin

DIOPT Version :9

Sequence 1:	NP_001260093.1	Gene:	Bsg25D / 33757	FlyBaseID:	FBgn0000228	Length:	1118	Species:	Drosophila melanogaster
Sequence 2:	XP_002936637.3	Gene:	nin / 779600	XenbaseID:	XB-GENE-954251	Length:	2101	Species:	Xenopus tropicalis

Alignment Length:	1439	Identity:	287/1439 - (19%)
Similarity:	526/1439 - (36%)	Gaps:	412/1439 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EVSADPYEQKLYQMFRSCETQ-CGLLDEKSLLKLCSLLELRDQGSALIASLGGSHQLG-VSFGQF 64
            |...|.||.:|.::|.|.:|. .|.||::.|..||.:|:|.:...:|..:|...:.|| |.|.||
Frog     3 EAEQDQYEARLKELFDSFDTTGTGSLDQEELTDLCHMLQLGEVAPSLQHALLQDNPLGRVHFDQF 67

  Fly    65 KEALLNFLGSEFDGNTSSGFIERSLVITDEPLNNTYIESPPESSDREVSPKLVVGTKKYGRRSRP 129
            ||||:                   ||:::...|....:.|  .|..|..||.:...|:|||||.|
Frog    68 KEALI-------------------LVLSNTLSNEDAFQEP--VSCTEAQPKYIKDGKRYGRRSMP 111

  Fly   130 QQGIYELSVTDSDNTDEDQLQQ------QQNQRSLNGCDE--LGVQVQRSSSQ--------SDLP 178
            :       :.||...||:.:.:      :.:|.|...|:|  ....|:..:::        .||.
Frog   112 E-------LQDSLEFDEETVIEPDDEGTRSSQVSSRNCEEPWKSEDVEEFTAEGQLRFWNPDDLS 169

  Fly   179 GSRRLRSVHTSG-----SKLKR-CASLPARRK--MNSNTTGATTSPTAAAKLKQLSIQSQAQH-- 233
            .|   ::|.|:.     .||:. |..|...|.  :|.....:.........|.:.:::...|:
Frog   170 AS---QNVCTTDHEWVEEKLQLICEDLGITRNDYLNRKKLISICEQYGLKNLDKETLEDVIQNLD 231

  Fly   234 ---SSSVESLGHRLATNPAP----SSEHWR---------CY-HGGRWSCCKDTVTPQQLETI--- 278
               :.|::...:.:..|..|    ||..:|         .| ..||     .|:||..:..:
Frog   232 QEKTMSLQDFFYEVCKNSKPLIPSSSTPYRQLKRHLSMPAYDESGR-----RTITPSSMGAVGIR 291

  Fly   279 ------------SVHSIMEAWELASIPNTRNLLHVLGFDEEEEVNLQQLTKALEEELRGIDGDHE 331
                        ||..:::.|:...|.|::.:|..|.|:.|.::||.:||..||.||.....:..
Frog   292 LLSKLDDGTGYGSVEDLIDLWQEEGIENSQAILKALDFNVEGKINLMELTMILEHELLMTKNEVY 356

  Fly   332 QSNMLRALAAL-----QATELGNYRLAYRQQHEENLKLRADNKAANQRVALLAVEVDERHASLED 391
            |:.::...:.:     ||.:....|...|...::|.||::.          :|.|||:.||.:|.
Frog   357 QAAVISFRSEIRHLLEQADQAAREREKLRSDLDKNEKLKSQ----------MASEVDDHHAEIER 411

  Fly   392 NSKKQVQQLEQRHASMVREITLRMTNDRDHWTSMTGK----LEAQLKSLEQEEIRLRTELELVRT 452
            .::..:::|::.:......:...:..:||.....:.|    ||.:|...:.||..||..|.|...
Frog   412 QNEYNLRKLDEEYKERTENLKNELRKERDQILQQSAKHRFELEQELDKAKAEENYLRDRLNLCLK 476

  Fly   453 ENTELESEQQKAHIQIT-----------------------------ELLEQNIKL---------- 478
            |:..||:|..:|..::|                             |.|.|..:|
Frog   477 ESCRLETELLQASEKLTEYESLACKLQRSLDNIMREKFGDMDPSCMEFLSQEERLEQMRKEYELQ 541

  Fly   479 ---------------------------------------NQELAQTSSSIGGTPEHSP------- 497
                                                   |:...:|...||  ||..|
Frog   542 RRELQDRIDELQLELEDYRTHGVRGSRRSLKKSLLEEMDNKNYTETDQGIG--PEDCPPLNMSIE 604

  Fly   498 -------LRPRR----------------HSEDKEEEMLQLMEK-------------------LAA 520
                   :|.:.                |.|::.:||..|.:|                   |..
Frog   605 AEMAIEQMREQHNREVEQLTTELQSKTTHCEEQLKEMKSLFDKEKAILKEQFEEEIQKAEVQLRF 669

  Fly   521 LQMENAQ-------LRDKTDELTIEIES--LNVELIRSKTKA---------KKQEKQEKQ----E 563
            |||::|:       |:|:...:..|.:|  .|.|.:.::.|.         :||..:.||    |
Frog   670 LQMQHAELEADIVKLKDEQYRIVCEHKSEISNREDLFNEQKGLLEEQEAALQKQLAENKQTFLKE 734

  Fly   564 DQESAATATKRRGDSPSKTH-LTEESPRLGKQRKCTEGEQSDASNSGDWLALNSEL--------- 618
            .:|.|.|..:...::.:|.: |||:.....||.:.:..||..:..:....||.:||
Frog   735 KEEFALTKKETEKETETKLYALTEKFETEKKQLEQSFKEQIASLTAKQKAALQNELAQAKQTLLL 799

  Fly   619 ---------------------QRSQSQDEEL-TSLRQRVAELEEELKAAKEGRSLTPESR----- 656
                                 ::|:.:..:| .|.|:::|.:.|..::.||..:...|:.
Frog   800 EKEEFAQTVEKDTEAKMIALTRKSEEEKRQLEQSFREQLARITERQQSEKEDWAKHSENHHHELQ 864

  Fly   657 ---------------------SKELETSLEQMQRAYEDCEDYWQTKLSEERQLFEKERQIYEDEQ 700
                                 ||:.|.:::..:.|....||.:|:.|.:......:|:..:|.|:
Frog   865 KERIKMETEYDKRISDMEFRFSKDFEATMKNHEEALAKLEDKYQSNLRDLTDKHTEEKSQWEFEK 929

  Fly   701 HESDKKFTELMEKVREYEEQFSKDGRLSPIDERDMLEQQYSE----LEAEAAQLRSSSIQMLEEK 761
            .|..:...|..|::||..|:...:...:.|.|:..||:.|.|    |..|..|:......::...
Frog   930 EEIIQDGLEAQERLRERLEKDKFEACSALIQEKVHLEKTYKEYINNLVVEKEQVEKDLENLMVNS 994

  Fly   762 AQEISSLQSEI----EDLRQRLGESVEILTGACELTSESVAQLSAEAGKSPASSPISYLWLQSTI 822
            .:|.|.|.::|    .||::.|.|..|.|   |: ..:::..|:...||..:...:....|.|.:
Frog   995 KKEESQLSAKISQLENDLQEELTERDEQL---CQ-AEKNLLVLTETIGKLESEHKLEKEHLCSKL 1055

  Fly   823 ---QEPAKSLADSKDEATASAIELLGGSPSHKTASRNNLTTSETSI----FSTTPFESSQSGPSP 880
               :|..|...|..:|.....:..:....|..|..:|.:  |..||    :.....|:.:.....
Frog  1056 EKSEEQYKEACDKAEEKKEGMVVEISRLQSTITGLQNEI--SSLSILQGNYHLMQIENEELKNLV 1118

  Fly   881 TNSGNSNAYGANPGPAPISKPKRSQSPQQAAASEG------------EIADCETSSTASGKSFES 933
            |:..|:.....:     :...|..|:..:....|.            ::..|:|     ||::..
Frog  1119 THLQNNACMEED-----MIVLKNLQNVHEQTVKENVRLVSEISKLRKKLDQCKT-----GKNWLP 1173

  Fly   934 NSKTSCLSHEKCSSPSALKEELKRLK--FFELSLKEQIKDLSLQRDGLVMELQQLQEARPVLEKA 996
            .....|.:.:|........|:...::  .|..|: |.::|.:|:....:.||:...||...:||:
Frog  1174 EPHNGCQTEKKQKLGVTENEDSHSVEGDHFSHSV-ETLEDFNLRLQSKIKELENTTEALTKMEKS 1237

  Fly   997 Y---------ARTTHPTLQQRLNQLELRNRHLQNVIKQQQHYTESLMQQSW------------RQ 1040
            |         .:|....:|:::.|:.|.|..::.||..::.....|.|.:.            ::
Frog  1238 YENAKAEYGHLQTQMLQMQEKMQQVTLENELMKKVISSEEFTVPDLEQTALTVPGLKLILAVAKK 1302

  Fly  1041 HQVELNDLHSRIETQGVLLADQTQRLQS-----------------ADILVKDLY----VENSHLT 1084
            ..::|.:..:.:|.:.|...:..:.|.|                 |.:.::::|    .|||.|.
Frog  1303 ENLQLQEKLNYMELKNVEAVNNNRELSSEVLWLQKEIQNMEEIAEASLKLENMYEETKKENSKLM 1367

  Fly  1085 ATVQRLEQQ 1093
            ..|..||::
Frog  1368 VLVANLEEK 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg25D	NP_001260093.1	SMC_prok_B	<306..545	CDD:274008	71/383 (19%)
		Smc	<428..777	CDD:224117	107/567 (19%)
		Spc7_N	<769..937	CDD:292045	33/190 (17%)
		GAS	951..>1053	CDD:290562	23/124 (19%)
nin	XP_002936637.3	Smc	<366..670	CDD:224117	52/315 (17%)
		SbcC	529..1122	CDD:223496	110/600 (18%)
		SbcC	871..1384	CDD:223496	100/523 (19%)
		SMC_prok_B	1420..>2087	CDD:274008
		Smc	<1486..1800	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003212
OrthoInspector	1	1.000	-	-		otm49478
Panther	1	1.100	-	-	O	PTHR18905
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100