DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg25D and nin

DIOPT Version :9

Sequence 1:	NP_001260093.1	Gene:	Bsg25D / 33757	FlyBaseID:	FBgn0000228	Length:	1118	Species:	Drosophila melanogaster
Sequence 2:	XP_009305783.1	Gene:	nin / 571879	ZFINID:	ZDB-GENE-070725-1	Length:	1399	Species:	Danio rerio

Alignment Length:	1440	Identity:	303/1440 - (21%)
Similarity:	529/1440 - (36%)	Gaps:	446/1440 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVSADPYEQKLYQMFRSCE-TQCGLLDEKSLLKLCSLLELRDQG-SALIASLGGSH-QLGVSFG 62
            |:.:.|.||::|.::|.|.: :..|.|..:.|..||..|:|.:.. :.|:.:|...| ...|.|.
Zfish    21 MDGARDQYEERLKEVFESFDGSGLGSLSPEELSDLCQALQLEENTLNTLLHTLLDDHITARVDFE 85

  Fly    63 QFKEALLNFLGSEFDGNTSSGFIERSLVITDEPLNNTYIESPPESSDREVSPKLVVGTKKYGRRS 127
            |||:||:..|.|     |::...|..|...|.|               ||.|:.|.|:|:|||||
Zfish    86 QFKDALILVLSS-----TNTNDEEECLEQPDSP---------------EVQPRFVKGSKRYGRRS 130

  Fly   128 RPQQGIYELSVTDS-----DNTDEDQLQQQQNQR------------------------------- 156
            .|:   :..:.|||     |..::|:..|:.:.|
Zfish   131 APE---FIPTHTDSNIQADDEEEKDEDAQESDDRTVPRKRERWNADMSISEEFEAEGQLHLWNPD 192

  Fly   157 --------SLNGCDELGVQVQRSSSQSDLP--GSRRLRSVHT--------SGSKLKRCA--SLPA 201
                    :|:.|| |..::|.:..|..||  |...|..:|.        .|..|.:||  ||..
Zfish   193 EPTTPRGKALSLCD-LEERLQNACLQLSLPVNGMATLSQLHALCQHIGIEVGEDLLQCADESLMD 256

  Fly   202 RRKMNSNTTGATTSPTAAA-----KLKQLSIQSQAQHSSSVESLGHRLATNPAPSSEHWRCYHGG 261
            .::..|.....:..||.:|     :||::       ||:..:..|.|:
Zfish   257 VQEFISCVINHSKPPTPSASTPYRQLKRI-------HSTQFDESGRRI----------------- 297

  Fly   262 RWSCC-KDTVTPQQLETIS-------VHSIMEAWELASIPNTRNLLHVLGFDEEEEVNLQQLTKA 318
              ||. ..|:..:....:.       |.:::..|....:.|:..:|..|.|:.|.:|||.:||.|
Zfish   298 --SCALSSTIALRVFSDLDDGSGHAPVETLLNRWMEEGVDNSSEILQALDFNLEGKVNLSELTVA 360

  Fly   319 LEEELRGIDGDHEQSNMLRALA----ALQATELGNYRLAYRQQHEENLKLRADNKAANQRVALLA 379
            ||.||........|:.:|...|    .|:..:|         :..|..::|.|...|.:..:.||
Zfish   361 LENELLSTKNSIHQAALLSFKAEIRHLLECVDL---------ERREKERIRFDLDTAEKLKSELA 416

  Fly   380 VEVDERHASLEDNSKKQVQQLEQRH----ASMVREITLRMTNDRDHWTSMTGKLEAQLKSLEQEE 440
            .|||:.||::|.|::..::::||.:    .::..|::..|...:........:||.::..:..:|
Zfish   417 SEVDDHHAAIERNNELNLRRVEQEYKESMTALRTELSKEMELVQQQANQQREELEQEISKMRDDE 481

  Fly   441 IRLRTELELVRTENTELESEQQKAHIQITELLEQNIKLNQELAQTSSSIGGT--PEHSPLRPRRH 503
            ..||..|.|...||..||||       :.|..|:.::...:|.:...::.|.  .:...|.|...
Zfish   482 TFLREHLTLTIKENGRLESE-------LIETTEKLVEAENQLNKVQKNLDGVLKEKFGDLDPDSA 539

  Fly   504 SEDKEEEMLQLMEKLAALQMENAQLRDKTDELTIEIE---------------SLNVELIRSKTKA 553
            ...::|:.|:.:.:  :.:.:..:|:|:.|||..::|               ||:.|:.....:.
Zfish   540 EFYQQEDRLRQLRR--SYEEQCRELQDRIDELEAQLEEYQTSGHTPLRRPGLSLSDEMASKSLEP 602

  Fly   554 KKQEKQEKQEDQESAATATKRRGDSPSKTHLTEESPRLGKQRKCTEGEQSDASNSGDWLALNSEL 618
            ..||:|......|:.....:.:.:..:...:.:|..|..::.|             |.|:||.:
Zfish   603 GFQEQQPLNMSLETEMLLEQHQREIENIRAMVDEEKRSAEEEK-------------DLLSLNHQ- 653

  Fly   619 QRSQSQDEELTSLR-------QRVAELEEELKA-----AKEGRSLTPESR-----SKELETS--- 663
                   :||..||       :|..:||:|:..     .:|..|||.|::     :::|:..
Zfish   654 -------QELQVLRGEMERELERANKLEQEISVLQNLHQQELHSLTQEAQDAKTCAEQLQAKVQV 711

  Fly   664 LEQMQRAYED---------------CEDYWQTKLSEERQLFEKERQIYEDEQ-HESDKKFTEL-- 710
            ||:.|.|||:               .::..:|.:.|:|:..|:|::....|| .|..|.:.|:
Zfish   712 LEEKQTAYEEQSNAHAEEMSLMELKHQEMLETSMQEQRERLEEEKEKRLTEQWKEQQKSYEEMLN 776

  Fly   711 --MEKVREYEEQ--FSKDGRLSPIDERDMLEQQYSELEAEAAQLRSSSIQMLEEKAQEISSLQSE 771
              :|::::..||  ...:.||     ||..:|:..||| |:::.:.:||  |||:.:.   |:.|
Zfish   777 AQLEEMQQRTEQECTELEKRL-----RDEWDQEKQELE-ESSREKLNSI--LEERERR---LREE 830

  Fly   772 IEDLRQRLGE-SVEILTGACELTSESVAQLSAEAGKSPAS------------------------- 810
            .|..||.|.| |.|.|....|..||...:|..:..:..||
Zfish   831 WEQERQELEEISKEALQAVLEERSERETRLRQQWDEERASMENKHHALLLQHLQEEREHFRTQQE 895

  Fly   811 ---SPISYLW--------------LQSTIQEPAKSLADSKDEATASAIELL-----------GGS 847
               |.|...|              ||:.:::..:.|...::|..:...::|           .|:
Zfish   896 ETESIIFEHWARERAQLERQHKEALQACLEQERERLQVDREEQESRWQQVLIEEQSRVEEAHRGA 960

  Fly   848 PSHKTASRNNLTTSETSIFSTTPFESSQSGPSPTNSGNSN-------------AYGANPGPA--- 896
            ....||..|......:|:......:.::...........|             ....|...|
Zfish   961 MLELTAKHNEERERLSSLLEKLRTDIAEQRSEVCRLAKENFILRHKISTVREQDLRENQDDARLQ 1025

  Fly   897 PISKPKRSQSPQQAAASE----GEIADCETSSTASGKSF---------------ESNSKTSCLSH 942
            .|.:.|||....:...||    |:..:.|:.........               .:|.|......
Zfish  1026 HIKQGKRSVQALRRQLSEPRRLGQQLEEESFILQQNSDHVLRHALQEVIRQHDGSANGKNGLCDR 1090

  Fly   943 EKCSS---PSALKEELKRL--KFFELS------------LKEQIKDLSLQRDGLVMEL----QQL 986
            |:.||   ...|:.||.|.  |...|.            ||..::....:||.|..|:    :||
Zfish  1091 EEISSRTEKELLRSELNRCIEKIMSLDSSLQTVTQQNARLKSDLRITQQERDALKQEVMSLHKQL 1155

  Fly   987 QEA-RPVLEKAYARTTH-------------------------PTLQQRLNQL--ELRN-----RH 1018
            |.| ..:||.:.....|                         ..|::::|:|  ||:.     ||
Zfish  1156 QSANEKLLEVSVVSAGHQQGRRVWAELSGLMEAEHHSLKEENQQLKRQMNELSSELQTSKEQIRH 1220

  Fly  1019 LQNVIKQQ--------------------------------------------------------- 1026
            |:.:..:|
Zfish  1221 LEALSAKQRGIVKNADQEKSALKREMEALHSQLLSTRNKAQLAAILPSSPLHLAGEQRGSHNSDG 1285

  Fly  1027 -----QHYTESLMQQSWRQHQVE--LNDLHSRIETQGVLLADQTQRLQSADILVKDLYVENSHLT 1084
                 |....:|:|...|..:||  |.:|...::.:...|.:|..|...:|:|:|||||||:.|.
Zfish  1286 PDFNIQEREAALLQMEERMREVEITLRNLKLLLQEKVSQLKEQLIRNSESDVLIKDLYVENAQLL 1350

  Fly  1085 ATVQRLEQQR 1094
            ..:::.||::
Zfish  1351 KALEKTEQRQ 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg25D	NP_001260093.1	SMC_prok_B	<306..545	CDD:274008	62/263 (24%)
		Smc	<428..777	CDD:224117	91/407 (22%)
		Spc7_N	<769..937	CDD:292045	40/256 (16%)
		GAS	951..>1053	CDD:290562	36/216 (17%)
nin	XP_009305783.1	DUF342	<501..581	CDD:302792	15/88 (17%)
nin	XP_009305783.1	Smc	624..>1379	CDD:224117	150/769 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4877
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003212
OrthoInspector	1	1.000	-	-		otm25964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18905
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8624
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.110