DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg25D and NIN

DIOPT Version :9

Sequence 1:	NP_001260093.1	Gene:	Bsg25D / 33757	FlyBaseID:	FBgn0000228	Length:	1118	Species:	Drosophila melanogaster
Sequence 2:	XP_024305390.1	Gene:	NIN / 51199	HGNCID:	14906	Length:	2163	Species:	Homo sapiens

Alignment Length:	1500	Identity:	329/1500 - (21%)
Similarity:	541/1500 - (36%)	Gaps:	466/1500 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EVSADPYEQKLYQMFRSCETQ-CGLLDEKSLLKLCSLLELRDQGSALIASLGGSHQLG-VSFGQF 64
            ||..|.:|.:|.::|.|.:|. .|.|.::.|..||.:|.|.:....|..:|...:.|| |.|.||
Human     3 EVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQF 67

  Fly    65 KEALLNFLG------SEFDGNTSSGFIERSLVITDEPLNN----TYIESPPESSDREVSPKLVVG 119
            ||||:..|.      ..|....|.|...:.:.....||.|    |:.....:.| .|..||.|.|
Human    68 KEALILILSRTLSNEEHFQEPASVGVSCQQVARVSGPLLNGHKLTHCLLIKDCS-LEAQPKYVRG 131

  Fly   120 TKKYGRRSRP--QQGIYEL-SVTDSDNTDE----------DQLQQQQNQRSLNGCDELGVQVQ-R 170
            .|:|||||.|  |:.:.|. .||..:..||          |..:..:.|||    :|...:.| |
Human   132 GKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRS----EEYEAEGQLR 192

  Fly   171 SSSQSDLPGSRRLRSVHTSGS---------KLKR-CASLPARRKMNSN----------------- 208
            ..:..||..|:       |||         ||:. |..|...|..:.|
Human   193 FWNPDDLNASQ-------SGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVD 250

  Fly   209 ---------------------------TTGATTSPTAAAKLKQLSIQSQAQHSS--SVESLGHRL 244
                                       ..|.:.:|:|:...:||.     :|.|  |.:..|.|.
Human   251 GEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLK-----RHLSMQSFDESGRRT 310

  Fly   245 ATNPAPSSEHWRCYHGGR-WSCCKDTVTPQQLETISVHSIMEAWELASIPNTRNLLHVLGFDEEE 308
            .|:.|.:|.     .|.| :||..|     .:...||..|::.|:...|.|::.:|..|.|..:.
Human   311 TTSSAMTST-----IGFRVFSCLDD-----GMGHASVERILDTWQEEGIENSQEILKALDFSLDG 365

  Fly   309 EVNLQQLTKALEEELRGIDGDHEQSNMLRALAALQATELGNYRLAYRQQHEENLKLRADNKAANQ 373
            .:||.:||.|||.||........|:    |||:.:| |:.:......|...|..|||:|...|.:
Human   366 NINLTELTLALENELLVTKNSIHQA----ALASFKA-EIRHLLERVDQVVREKEKLRSDLDKAEK 425

  Fly   374 RVALLAVEVDERHASLEDNSKKQVQQLEQRHASMVREITLRMTNDRDHWTSMTGK----LEAQLK 434
            ..:|:|.|||:.||::|..::..:::|::.:...:..:...:..:|:......||    ||.:::
Human   426 LKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE 490

  Fly   435 SLEQEEIRLRTELELVRTENTELESE-----QQKAHIQ-ITELLEQNI----------------- 476
            ..:.||..:|..|.|...||:.||:|     ::.|..: :|..|::|:
Human   491 KAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAE 555

  Fly   477 ---------------------------KLNQELAQ--------------------TSSSIGGTPE 494
                                       :|..||.:                    .::|.|..||
Human   556 FFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 620

  Fly   495 H-------SPL-------------RPRRHS---------EDK----------------------- 507
            |       :||             :.:.|.         |||
Human   621 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMK 685

  Fly   508 ----------EEEMLQLMEKLAALQMENAQLRDKTDELTI----EIESLNVELIRSKTKAKKQEK 558
                      |:::..|..::|.||.:.|.|::...|.|.    |.:.|.|:|...||..  |||
Human   686 QRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHL--QEK 748

  Fly   559 QEKQEDQESAATATKRRGDSPSKTHLTEESPRLGKQRKCTEGEQSDASNSGDWLALNSELQRSQS 623
            ...|.:.|             .|..||:......::|   ||.||.|........|..||:  |.
Human   749 LRLQHEME-------------LKARLTQAQASFERER---EGLQSSAWTEEKVRGLTQELE--QF 795

  Fly   624 QDEELTSL-RQRVAELEE-----------ELKAAKEGRSLTPESRSKELETSLE-QMQRAYEDCE 675
            ..|:|||| .:...|.||           ||:..:|........|:.::|...: ..|:..|.||
Human   796 HQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCE 860

  Fly   676 DYWQTKLSEERQ----LFEKERQIYEDEQHESDKKFTELMEKVREYEEQFSKDGRLSPI--DERD 734
            ...|:.....||    |.|::|:.....:.|.|:...|..|.....:|...::...|.:  .||:
Human   861 SALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQERE 925

  Fly   735 MLEQQYSE-----------------------------LEAEAAQLRSSSIQMLEEK--------- 761
            |||:.|.|                             |..:..:|:||..:.|.|:
Human   926 MLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 990

  Fly   762 -----AQEISSLQSEIEDLRQRLGESV----EILTGACELTSESVAQLSAEAGK--------SPA 809
                 :|.:..|:.|.:..||.:...:    .|....||......|::|.|..:        ..|
Human   991 SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQA 1055

  Fly   810 SSPISYL---------------WLQSTIQEPAKSLADSKDEATASAIELLGGSPSHKTASRNN-- 857
            :||:|.|               ...|.:|:..:.|.::.|       .||....:|:.|.:.|
Human  1056 TSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGD-------VLLSLQRAHEQAVKENVK 1113

  Fly   858 ------------------------LTTSETSIFSTTPFESS---QSGPSPTNSGNSNAYGANP-- 893
                                    |....|..|..|..::.   |...:....|.:..:..:.
Human  1114 MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLE 1178

  Fly   894 -------GPAPISKPKRSQ-SPQQAAASEGEIADCETSSTASGKSFESNSKTSCLSHE------K 944
                   |....|..:|.: ..:::.||....::.|.|.....:|:|..::.|.|..:      .
Human  1179 DDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1243

  Fly   945 CSSPSALKEELKRLKFFELS-LKEQIKDLSLQRDGLVMELQQLQEARPVLEKAYARTT--HPTLQ 1006
            |...|..|::|    .|::| ||:::|           .|:::.||.|..:..|...:  :..||
Human  1244 CDRASEKKQDL----LFDVSVLKKKLK-----------MLERIPEASPKYKLLYEDVSRENDCLQ 1293

  Fly  1007 QRLNQLELR-------NR-------HLQNVIKQQQHYTESL--MQQSWRQHQVE---LNDLHSRI 1052
            :.|..:|.|       |:       .||:.:|:.:..||:.  :::|:.:.::|   ||.|..|:
Human  1294 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRL 1358

  Fly  1053 ETQGVLLADQTQRLQSADILVKDLYVEN------SHLTATVQRLEQQRARVNLIHQ-----QQQQ 1106
              ||.:...|...:|..|..:.:..:||      .::....|.||:...||..:|.     :|:.
Human  1359 --QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1421

  Fly  1107 QRLVG 1111
            |.|.|
Human  1422 QYLEG 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg25D	NP_001260093.1	SMC_prok_B	<306..545	CDD:274008	75/378 (20%)
		Smc	<428..777	CDD:224117	109/550 (20%)
		Spc7_N	<769..937	CDD:292045	38/233 (16%)
		GAS	951..>1053	CDD:290562	29/123 (24%)
NIN	XP_024305390.1	Aminotran_5	335..>455	CDD:332979	40/124 (32%)
		SMC_N	<437..855	CDD:330553	84/437 (19%)
		APG6	859..>1003	CDD:309295	28/143 (20%)
		SMC_N	950..1678	CDD:330553	95/500 (19%)
		SMC_N	<1462..>2125	CDD:330553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003212
OrthoInspector	1	1.000	-	-		otm42249
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18905
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8624
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	7.020