DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg25D and Ninl

DIOPT Version :9

Sequence 1:	NP_001260093.1	Gene:	Bsg25D / 33757	FlyBaseID:	FBgn0000228	Length:	1118	Species:	Drosophila melanogaster
Sequence 2:	XP_038962579.1	Gene:	Ninl / 311529	RGDID:	1306152	Length:	1432	Species:	Rattus norvegicus

Alignment Length:	1501	Identity:	317/1501 - (21%)
Similarity:	523/1501 - (34%)	Gaps:	522/1501 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YEQKLYQMFRSCETQ-CGLLDEKSLLKLCSLLELRDQGSALIASLGGSHQLG-VSFGQFKEALLN 70
            |..:|..::.||:|. .|.||::.|.:||:.|.|.:|..||:..|.|..:|. |:|.:|||..:.
  Rat     9 YVSRLRDVYSSCDTTGTGFLDQEELTQLCTKLGLEEQLPALLHILLGDGRLARVNFEEFKEGFVA 73

  Fly    71 FLGSEFDGNTSSGFIERSLVITDEPLNNTYIESPPESSDRE------VSPKLVVGTKKYGRRSRP 129
            .|.|      ::|.         ||       |..|.|..|      |.||.:.|:|.|||||.|
  Rat    74 VLSS------ATGV---------EP-------SDEEGSSSESATSCAVPPKYMSGSKWYGRRSLP 116

  Fly   130 QQGIYELSVTDSDNTDEDQLQQQ---------QNQRSLNGCDELGVQVQRSSSQSDLP------- 178
            :.|       ||..|.:...:||         :...||...:.|     :|...::.|
  Rat   117 ELG-------DSATTTKCGSEQQAKGSVKPPLRRSASLESVESL-----KSDEDAESPKEPQNEL 169

  Fly   179 ----GSRRLRSVHTSGSKLKRCA---SLPARR------KMNSNTTGATTSPTAAAKLKQLSIQS- 229
                |..|.......|:..|.|:   :.|..:      ::...::|.......|...:.:.:..
  Rat   170 FEAQGQLRSWGCEVFGTPRKSCSPSFNTPENQVQGIWHELGVGSSGHLNEQELAVVCRSIGLHGL 234

  Fly   230 QAQHSSSVES-------------------LGHRLATNPAPSS-----EHWRCYHGGRWSCCKDTV 270
            :.|....:.|                   .||...:.||.||     ..|..|.  ..|.|..|.
  Rat   235 EKQELEELFSKLDRDGDGRVSLAEFQLGLFGHEPPSLPASSSLIKPNGPWSHYQ--EESGCHTTT 297

  Fly   271 TPQQLETIS----------------VHSIMEAWELASIPNTRNLLHVLGFDEEEEVNLQQLTKAL 319
            |...:...|                ...::.||....|.|.|.:|..|.|:.:|:|||.:||.||
  Rat   298 TSSLVSVCSGLRLFSSVDDGSGFAFPEQVISAWAQEGIQNGREILQSLDFNVDEKVNLLELTWAL 362

  Fly   320 EEELRGIDGDHEQSNMLRALAALQATELGNYRLAYRQQHEENLKLRADNKAANQRVALLAVEVDE 384
            :.||..:||..:|:    |||..: .||..::....|..:|..|.|.|.:.|.:|......|:|:
  Rat   363 DNELLTVDGVIQQA----ALACYR-QELNFHQGQVEQLVQERDKARQDLEKAEKRNLDFVREMDD 422

  Fly   385 RHASLEDNSKKQVQQLEQRHASMVREITLRMTNDRD-HWTS---MTGKLEAQLKSLEQEEIRLRT 445
            .|::||..::|:::.|||.:...:..:...:..:|: .|..   ....||..:..|:.||..||.
  Rat   423 CHSALEQLTEKKIKHLEQEYRGRLSLLRSEVEMERELFWEQARRQRAVLEQDVGRLQAEETSLRE 487

  Fly   446 ELELVRTENTELESEQQKAHIQITELLEQNIKLNQELAQTSSSIGGTPEHSPLRPRRHSEDKEEE 510
            :|.|...||:.|    ||..|::.|.|..:.||...|......:        |:.:  .|.:..|
  Rat   488 KLTLALKENSRL----QKEIIEVVEKLSDSEKLVLRLQSDLQFV--------LKDK--LEPQSME 538

  Fly   511 MLQLMEKLAAL----QMENAQLRDKTDELTIEIESLNVELIRSKTKAKKQEKQEKQEDQESAATA 571
            :|...|:..|:    :::...|:|:.|||..|:|.|.|.|.||:
  Rat   539 LLAQEEQFTAILNDYELKCRDLQDRNDELQAELEGLRVRLPRSR--------------------- 582

  Fly   572 TKRRGDSPSKTHLTEESPRLGKQRKCTEGEQSDASN--SGDWL--ALNSELQRSQSQD--EEL-T 629
                 .|||.|.        |..|:.|.| :..|.|  .|:.:  :|.:|::..|.::  :|| .
  Rat   583 -----QSPSGTP--------GTHRRWTPG-RGPADNLFVGESIPVSLETEIKMQQMKENYQELRM 633

  Fly   630 SLRQRVAELEEELKAAKEGRSLTPESRSKE----LETSLEQMQRAYEDCEDYWQTK------LSE 684
            .|..:|...|:|::..|  |:...:.:..|    ||.|:.:.|:|  |.|..:...      |.|
  Rat   634 QLETKVNYYEKEIEVMK--RNFEKDKKEMEQAFQLEVSVLEGQKA--DLETLYAKSQEVILGLKE 694

  Fly   685 ERQ-----------------------LFEK---ERQIYEDEQ----------------------- 700
            :.|                       |.::   |..:...:|
  Rat   695 QLQDAARSPEPAPAGLAPCCAQALCTLAQRLGVEMHLRHQDQLLQIRLSDTVTDSVLPRVCSPKG 759

  Fly   701 ------HESDKKFTELMEKVREYEEQFSKDGRLSPID----------------ERDMLEQQY--- 740
                  |.:.|:.||.....||.||:.::  :||.::                |:|.|.|.:
  Rat   760 SRKRTGHPNTKQTTERRVSGREAEEELNQ--KLSWLEAQHAACCESLSLQHQCEKDQLLQTHLQR 822

  Fly   741 -----SELEAEAA----------------QLRSSSIQMLEEKAQEISSLQSEIEDLRQRLGESVE 784
                 ::|:.|..                ||:..:: |.||:|:...|...|.|.|.|...|.||
  Rat   823 VKDLAAQLDLEKGWREEREQEVLAHCRRQQLKLQAV-MSEEQARICRSFTLEKEKLEQTYREQVE 886

  Fly   785 -----------ILTGACELTSESVAQLSAEAGKSPASSPISYLWLQSTI----------QEPAKS 828
                       :|.....:.|:...::.......|.|......|  .|:          :.|...
  Rat   887 GLVQEADVLRALLKNGTTVVSDQQERIPGSMYPGPDSRQQPPTW--QTVSPDGRTGAPAEWPGPG 949

  Fly   829 LADSKD--------EATASAI-ELLGGSPSHKTASRNN----LTTSETSIFSTTPFESSQSGPSP 880
            .||.:|        :|..|.. .||....|.....|:|    |:..|.::    |.|...|..:.
  Rat   950 RADGRDLPGQLCSLDAVPSPTPTLLSRRSSESLDVRDNHQGPLSAEEGAV----PKEPEPSARTL 1010

  Fly   881 TNSGNSNAYGANP-------GPAPISKPKRS---------------------------------- 904
            |...........|       |||.:.:...|
  Rat  1011 TGQDQKLPLPIQPQMLEPWLGPAAVDRKPDSVRVQGQASEGPTGDDKGVQETPLQLRGETARMRP 1075

  Fly   905 -------QSPQQA----AASEGEIADCETS----------------------------------- 923
                   .:||:|    ..||.|:.|.:|.
  Rat  1076 SLPYSELPNPQEAKVMSVMSESEMNDVKTKLLQLEDVVRALEKADSRESYRAELQRLSEENSVLK 1140

  Fly   924 -----------------------------------------STASGKSFESNSKTSC-------- 939
                                                     ||.:.|..:..|:.:|
  Rat  1141 SDLGKIQLELGTSESRNEVQRQEIEVLKRDKEQACFDLEELSTQTQKYKDEMSQLNCRILQLEGD 1205

  Fly   940 ---LSHEKCSSPSALKEELKRLKFFELSLK---EQIKDLSLQRDGLVMELQQLQ----EARPVLE 994
               |..:|..:.:|::..:|:|:..|...|   :|||.|.::.:.:..|.|:|:    |....||
  Rat  1206 SSGLHTQKEENHAAIQVLMKKLEEAECREKQQGDQIKHLKIELERVNEECQRLRLSQAELTGSLE 1270

  Fly   995 KAY------------ARTTHPT----LQQRLNQ-------------LELRNRHLQNVIKQQQHYT 1030
            ::.            |::.|..    ||::::|             |.||....:.:..||:.|.
  Rat  1271 ESQGQLHSVQLRLEAAQSQHDRIVQGLQEQMSQLVPGARVAELQHLLSLREEEAERLNAQQEEYK 1335

  Fly  1031 ESLMQQSWRQHQVELNDLHSRIETQGVLLADQTQRLQS-------ADILVKDLYVENSHLTATVQ 1088
            :.|..   |:.|||  :..:|:.....||.::.:.|:.       :|:|:|:|||||:||...||
  Rat  1336 QQLKA---REDQVE--EAEARLHNVEWLLQEKVEELRKQFEKNTRSDLLLKELYVENAHLMKAVQ 1395

  Fly  1089 RLEQQR 1094
            ..|:::
  Rat  1396 LTEEKQ 1401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg25D	NP_001260093.1	SMC_prok_B	<306..545	CDD:274008	70/246 (28%)
		Smc	<428..777	CDD:224117	100/464 (22%)
		Spc7_N	<769..937	CDD:292045	47/329 (14%)
		GAS	951..>1053	CDD:290562	31/137 (23%)
Ninl	XP_038962579.1	EF-hand_7	11..71	CDD:404394	23/59 (39%)
		EF-hand_7	199..260	CDD:404394	4/60 (7%)
		SMC_prok_B	<340..>913	CDD:274008	145/633 (23%)
		Smc	<1096..1425	CDD:224117	59/311 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342046
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003212
OrthoInspector	1	1.000	-	-		otm46404
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18905
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6308
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030