DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg25D and Nin

DIOPT Version :9

Sequence 1:	NP_001260093.1	Gene:	Bsg25D / 33757	FlyBaseID:	FBgn0000228	Length:	1118	Species:	Drosophila melanogaster
Sequence 2:	XP_006515591.1	Gene:	Nin / 18080	MGIID:	105108	Length:	2122	Species:	Mus musculus

Alignment Length:	1443	Identity:	323/1443 - (22%)
Similarity:	529/1443 - (36%)	Gaps:	469/1443 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EVSADPYEQKLYQMFRSCET-QCGLLDEKSLLKLCSLLELRDQGSALIASLGGSHQLG-VSFGQF 64
            ||..|.:|.:|.::|.|.:| ..|.|.::.|..||.:|.|.|.|..|..:|...:.|| |.|.||
Mouse     3 EVEEDQHEARLKELFDSFDTLGTGSLGQEELTDLCHVLCLEDVGPVLQQTLLQDNLLGRVHFDQF 67

  Fly    65 KEALLNFLGSEFDGNTSSGFIERSLVITDEPLNNTYIESPPESSD--REVSPKLVVGTKKYGRRS 127
            ||||                    ::|....|::   |...|.||  .|..||.|.|.|:|||||
Mouse    68 KEAL--------------------ILILSRTLSS---EEHFEESDCSPEAQPKYVRGGKRYGRRS 109

  Fly   128 RPQ-----QGIYELSVTD---------------------SDNTDEDQLQQQ---QNQRSLNG--- 160
            .|:     :.|.|::|.:                     :..::|.:.:.|   .|...||.
Mouse   110 LPEFQESGEEIEEVTVLEPLEEEARSSPIPAGDCGEHWKTQRSEEYEAEGQLRFWNPDDLNASHG 174

  Fly   161 ----------------CDELGVQVQRSSSQSDLPGSRRLRSV-------HTSGSKLKRC-ASLPA 201
                            |::||:      ::......::|.|:       :..|:.|:.. .||..
Mouse   175 GSCPPPDWIEEKLQEVCEDLGI------TRDGHLNRKKLVSICEQYGLQNVDGAMLEEVFLSLDP 233

  Fly   202 RRKMNSN-------TTGATTSPTAAAKLKQLSIQSQAQHSS--SVESLGHRLATNPAPSSEHWRC 257
            ...|:..       .||.:.:|:|:...:||.     :|.|  |.:..|.|.||:.|.:|.
Mouse   234 DGTMSVEDFFYGLFKTGKSLTPSASTPYRQLK-----RHLSMQSFDESGRRTATSSAMTST---- 289

  Fly   258 YHGGRWSCCKDTVTPQQLETISVHSIMEAWELASIPNTRNLLHVLGFDEEEEVNLQQLTKALEEE 322
             .|.|...|.|....|    .||..|::.|:...|.|::.:|..|.|..:..:||.:||.|||.|
Mouse   290 -IGFRVFSCLDDGMGQ----ASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENE 349

  Fly   323 LRGI-DGDHEQSNMLRALAALQATELGNYRLAYRQQHEENLKLRADNKAANQRVALLAVEVDERH 386
            |... :|.|:     .|||:.:| |:.:......|...|..|||:|...|.:..:|:|.|||:.|
Mouse   350 LLVTKNGIHQ-----AALASFKA-EIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHH 408

  Fly   387 ASLEDNSKKQVQQLEQRHASMVREITLRMTNDRDHWTSMTGK----LEAQLKSLEQEEIRLRTEL 447
            |::|..::..:::|::.:...:..:...:..:|:......||    ||.:::..:.||..:|..|
Mouse   409 AAIERRNEYNLRKLDEEYKERIAALKNELRQEREQMLQQVGKQRVELEQEIQKAKTEENYIRDRL 473

  Fly   448 ELVRTENTELESE---------------------------------------------------- 460
            .|...||..||:|
Mouse   474 ALSLKENNRLETELLENAEKLAEYESLTQKLQRSLENVLAEKFGDLDPSSAEFFLQEERLAQMRN 538

  Fly   461 --QQKAHI---QITEL---LEQ------------NIKLNQELAQTSSSI-----GGTPEHSPLR- 499
              :|:..:   |:.||   ||:            ...|::||...|..|     .|:.|.:||.
Mouse   539 EYEQQCRLLQDQVDELQSELEEYQAQGRVLRLPLKNSLSEELDGHSGGIEPDQGPGSEECNPLNM 603

  Fly   500 -----------PRRHSEDKEEEMLQLMEKL-----------AALQMENAQLRDK----------- 531
                       ..:|..|.....|:|.:|:           .|.:.|.|.::.|
Mouse   604 SIEAELVIEQMKEQHHRDLCHLRLELEDKVRHYEKQLDDTRVASEQEQAAMKQKYEQGVHTLEKR 668

  Fly   532 TDELTIEIESLNVE---LIRSKTKAKKQEKQEKQE-----DQESAATATKRRGDSPSKTHLTEES 588
            ..||..||..|..:   |..:..||..:.::||::     |:|.|....:.|     :.|..|..
Mouse   669 VSELRSEIADLEGQAAVLREAHHKASCRHEEEKRQLQMAFDEEKAQLQEELR-----QEHERELQ 728

  Fly   589 PRLGKQRKCTEGEQSDASNSGDWLALNSELQR--SQSQDEELTSLRQRVA----ELEEEL----- 642
            .||.:..:....|:...:.:    |...|..|  .||..|:|.||.::.|    ||.|||
Mouse   729 ARLQQAAESFRQEREGLAQA----AWTEEKVRGLEQSYQEQLLSLEEKHALEKEELREELSEHHR 789

  Fly   643 KAAKEGRSLTPESRSKELETSLEQ------------MQRAYEDCEDYWQT----KLSEERQLFE- 690
            :..:|||        :|:||...:            .::..|.||...|:    ...|.|.|.:
Mouse   790 RELQEGR--------EEMETECNRRVSQIEAQCQADCEKVTEHCEQTLQSLEVRHRQELRDLLDQ 846

  Fly   691 --KERQIYEDEQHESDKKFTELMEKVRE----------------------YEEQF---------- 721
              :||..:|.|:.|..::.|:..|:::|                      |:::.
Mouse   847 HLEERSQWEFEKDELTQECTDAQEQLKEALQRERATAAAMKQEQEILERTYKDRLNILSTERKQL 911

  Fly   722 ------------SKDGRLS-------PIDERDML---------------------------EQQY 740
                        |:.|.||       ...||::.                           ||:.
Mouse   912 LQDLKDLQNASESQHGLLSGQILELKRSQERELRDQGQALCQTGVSEQLASQQLERLRVEHEQER 976

  Fly   741 SELEAEAAQLRSSSIQMLE----EKAQ---EISSLQSEIEDLRQRLGESVEILTGACELTSESVA 798
            .|:..:.|.|.|:....||    |||:   ||..||:.::|::|  ..|:.:|.|.|:.|:...|
Mouse   977 REMTGKLAALESAHRASLERADQEKAEMSTEICRLQNTVKDMQQ--AASLLMLQGGCQATAGEEA 1039

  Fly   799 -------------QLSAEAGKSPASSPISYLWLQSTIQEPAKSLADSKDEATASAIELLGGSPSH 850
                         ||..|.|....|       ||...:...|..|....|.:.....|....|..
Mouse  1040 EGDGAMSLLQQGEQLLEENGDVLIS-------LQRAHEHAVKENAKMATEISRLQQRLKKLEPGS 1097

  Fly   851 KTASRNNLTTSETSIFSTTPFES-SQSGPSP----TNSGNSNAYG-ANPGPAPISKPKRSQSPQQ 909
            ..:|.....|||.|..|....|. .:.||:.    ::.|:..|.. |:.|.:.:.:.:     .:
Mouse  1098 VISSCLEEGTSEISGSSREQVEPIMKQGPATKHFLSDLGDHEARDLASTGTSSVQRQE-----CK 1157

  Fly   910 AAASEGEIADC----ETSSTASGKSFESNSKTSCLSHE------KCSSPSALKEELKRLKFFELS 964
            ..|||..: ||    |.|.....:|::..|:.|.|..:      .|...|..|::|    .|::|
Mouse  1158 TEASEASL-DCFSELENSEDTRTESWDLKSQISQLREQLTVLRADCDRASERKQDL----LFDIS 1217

  Fly   965 -LKEQIKDLSLQRDGLVMELQQLQEARPVLEKAY--ARTTHPTLQQRLNQLELRNRHLQNVIKQQ 1026
             ||:::|           .|::|.||....:..|  |...:..||:.|..:|.|
Mouse  1218 VLKKKLK-----------MLERLPEASSRYKVLYEDAARENSCLQEELRLVETR----------- 1260

  Fly  1027 QHYTESLMQQSWRQHQVELNDLHSRIETQGVLLADQTQRLQ-------SADILVKDLYVENSHLT 1084
              |.|||             |.:..:..:...|.|:.::::       |.:....::.|||..|.
Mouse  1261 --YEESL-------------DSNKELTAEVYRLQDEMKKMEEVMETFLSLEKSYDEVKVENEELR 1310

  Fly  1085 ATVQRLEQQRARV 1097
            |.|.||:.:..:|
Mouse  1311 ALVLRLQGKMEKV 1323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg25D	NP_001260093.1	SMC_prok_B	<306..545	CDD:274008	76/354 (21%)
		Smc	<428..777	CDD:224117	115/586 (20%)
		Spc7_N	<769..937	CDD:292045	43/190 (23%)
		GAS	951..>1053	CDD:290562	23/104 (22%)
Nin	XP_006515591.1	SMC_prok_B	354..1095	CDD:274008	158/772 (20%)
		SMC_prok_B	869..1735	CDD:274008	105/511 (21%)
		SMC_prok_B	1428..>2112	CDD:274008
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838274
Domainoid	1	1.000	96	1.000	Domainoid score	I7319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4859
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003212
OrthoInspector	1	1.000	-	-		otm44302
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18905
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8624
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	9.070