Protein Alignment Nin and Bsg25D

DIOPT Version :10

• Sequence 1: NP_001260093.1
• Gene: Nin / 33757
• FlyBaseID: FBgn0000228
• Length: 1118
• Species: Drosophila melanogaster
• Sequence 2: XP_061516375.1
• Gene: Bsg25D / 1278069
• VectorBaseID: AGAMI1_011531
• Length: 1514
• Species: Anopheles gambiae
• Alignment Length: 1561
• Identity: 487/1561 - (31%)
• Similarity: 699/1561 - (44%)
• Gaps: 490/1561 - (31%)

  Fly     1 MEVSADPYEQKLYQMFRSCETQ-CGLLDEKSLLKLCSLLELRDQGSALIASLGGSHQLGVSFGQF 64
            |.:|:||||||||.||::..:. .|:||..:|:|||..|||:::|..|:..|....:..|||.:|
Mosquito     1 MALSSDPYEQKLYHMFQAHSSPGNGVLDRDALVKLCHTLELKERGHLLVKCLMTGSKTHVSFREF 65

  Fly    65 KEALLNFLGSEFDGNTSS----------------------------------------------- 82
            :|.||:.||.. ||::|.
Mosquito    66 REGLLHILGGN-DGSSSQQPAGTGDLDAAATSPSTRSREAYEESDSDHPDQQSQQQQQQQKQEVL 129

  Fly    83 ----------------------------------------------------------------- 82
                                                                             
Mosquito   130 DQQMASYASPVCLTTPGKANHIGGNAGSNSSTISSTSSNSSTSGSPSFHSAAGKFSNGGSSSNSG 194

  Fly    83 ---------------------GFIERS--------LVITDEPLN--------------------- 97
                                 |..|.|        .|:..|..|
Mosquito   195 STHKHRSPTQQRSSSAPKPFHGKTETSGHKLPHEEEVVEKEKKNVSLSTVIGHAKTLPHDKQKTS 259

  Fly    98 --------NTYIESP------------PESSDREVSPKLVVGTKKYGRRSRPQQGIYEL-SVTDS 141
                    |.::..|            .|:||||||||.|||||||||||||::.:..| |.:.|
Mosquito   260 VDGVPVDDNEFMSQPIVNRLPKHEAEVDETSDREVSPKFVVGTKKYGRRSRPREDVNGLDSSSLS 324

  Fly   142 DNTDEDQL-----------------QQQQ-----------NQRSLNGCDEL-GVQVQRSSSQSDL 177
            .|:|.:.:                 ::::           .|..:.|...: ..:||||:||||:
Mosquito   325 SNSDNESVTVKSAARKTAAAAAAAAEEEEPISVHHVPGRTRQSFITGTGTVASSKVQRSASQSDI 389

  Fly   178 PGSRRLRSVHTSG---SKLKRCASLPARR------KMNSNTTGATTSP----------------T 217
            .||:|.|.|...|   ::||||||||..|      :...|||..|...                .
Mosquito   390 HGSKRRRPVMAGGTGVNRLKRCASLPTHRQRPTVVESKRNTTTVTIREQLHMDDDRIDQKIYFMN 454

  Fly   218 AAAKLKQL-------------SIQSQAQHSSSVESLG-----HRLA------------------- 245
            .:..|:::             .:.:|||.....|.:|     .|||
Mosquito   455 LSENLREIWDSLLLDSDRRHGDLLNQAQLEEVCERVGLQKVPARLAAQEVFNKLSLQPIEGIGFE 519

  Fly   246 ---------TNPAPSSEHWR-----CYHGGRWSCCKDTVTPQ--------------QLETISVHS 282
                     |:..|.||...     |..||..:.....|:|:              ::.:::...
Mosquito   520 EFIALLESNTDLLPMSETKELQLGDCGTGGSPTVTPSVVSPEESAFTLAMPPDWTSEIGSLAASI 584

  Fly   283 IMEAWELASIPNTRNLLHVLGFDEEEEVNLQQLTKALEEELRGIDGDHEQSN------------- 334
            |::.||.|.|....||||.|||| .:.:.:..|.:|||||.:.:...|..|:
Mosquito   585 IIDMWESAGIDAPANLLHDLGFD-RDVIQVADLVQALEEEHQRLVSGHMNSSTISNISSNPFDDA 648

  Fly   335 --MLRALAALQATELGNYRLAYRQQHEENLKLRADNKAANQRVALLAVEVDERHASLEDNSKKQV 397
              ::||..||...|:...|.|:.|..|||.||.||||..|.|..|||.||||||.|||::::.::
Mosquito   649 ALIVRASLALHKAEVTALRQAFHQLVEENKKLYADNKEVNHRAVLLAQEVDERHNSLENSTRTKI 713

  Fly   398 QQLEQRHASMVREITLRMTNDRDHWTSMTGKLEAQLKSLEQEEIRLRTELELVRTENTELESEQQ 462
            :.|||||...|:|::.::..:|:..:.....||.::::||.||.:|:||:..:..||.||..:|:
Mosquito   714 RHLEQRHHETVKELSSQLAFEREQLSHANAMLEKRIQALEGEEGKLKTEISRLAEENDELRQDQE 778

  Fly   463 KAHIQITELLEQNIKLNQELAQTSSSIGGTPEHSPLRPRRHSEDKE--------EEMLQLMEKLA 519
            ....:||:|||:|||||:::|:...:          ....:::|.|        ||:|.|:::::
Mosquito   779 NLTKEITDLLEKNIKLNRDIAELEEN----------NRNDYADDDECGFVRKDSEEVLDLIDRIS 833

  Fly   520 ALQMENAQLRDKTDELTIEIESLNVELIRSK----TKAKKQEKQEKQEDQESAATATKRRGDSPS 580
            .||.||..||||.|||:.|||:|||||.:.|    |.|.:........|..:::.|.||||||||
Mosquito   834 LLQSENTGLRDKNDELSAEIETLNVELSKFKLKRCTTAAEDLSAAGSGDGPASSAAIKRRGDSPS 898

  Fly   581 KTHLTEESPRLGKQRKCT-EGEQSDASNSGDWLALNSEL-------------------------- 618
            ||.|.:||.||||.|:|: |.:....|:||||:||:|||
Mosquito   899 KTRLADESHRLGKFRRCSNENDIESDSSSGDWMALHSELGQSLRGAEVAGCAELTGASSGISSMN 963

  Fly   619 QRSQSQDEELTSLRQRVAELEEELKAAKEGRSL-----------------------------TP- 653
            :.|.|:|:|:.:||.|:.|||.:||.||:..:|                             ||
Mosquito   964 ESSLSRDDEIKTLRARIEELEVQLKEAKKEIALPEQVPAAEESANVAVTSSEVAAPTPAENSTPT 1028

  Fly   654 --------ESRSKELETSLEQMQRAYEDCEDYWQTKLSEERQLFEKERQIYEDEQHESDKKFTEL 710
                    ::|.:|||:|||||::.|||||||||||:::||.|       ||:||..||:|||||
Mosquito  1029 KEEECKKLKARCEELESSLEQMRKEYEDCEDYWQTKVNDERLL-------YEEEQRMSDEKFTEL 1086

  Fly   711 MEKVREYEEQFS------KDGRLSPIDERDMLEQQYSELEA--EAAQLRSSSIQMLEEKAQEISS 767
            ::||.||||||:      ||||||||||:|.|||||.||||  |.|||      .|||:..|:..
Mosquito  1087 LKKVAEYEEQFAGNSKMEKDGRLSPIDEKDGLEQQYLELEADFEQAQL------ALEERTSEVEK 1145

  Fly   768 LQSEIEDLRQRLGESVEILTGACELTSESVAQLSAEAGKSPASSPISYLWLQSTIQEPAKSLADS 832
            |:..|:::.|......|:      |.|.|....:.:....||||||||||.|||||.|.:...:.
Mosquito  1146 LRRRIQEMEQMHKYPSEM------LLSPSPRVETPDVEDRPASSPISYLWNQSTIQRPVRDYQNP 1204

  Fly   833 --KDEATASAIELLGGSPSHKTASRNNLTTSETSIFSTTPFESSQSGPSPTNSGNSNAYGANPGP 895
              :....|:||            |.:.||..:.||...||..:.    ..|.:.:|...|::...
Mosquito  1205 NWRPPTVANAI------------SESVLTEEKCSIAVATPLNAE----GVTENKSSEFMGSSTEV 1253

  Fly   896 --------------APISKPK----RSQSPQQAAASEGEIADCET------------SSTASGKS 930
                          :||.||.    .......:.|.|.|...|.|            .|..|.:|
Mosquito  1254 VDVAAASSSFDRIISPIQKPTTVVGSFDGESSSGAKEDESQHCTTVAVLDQVDASDACSVKSARS 1318

  Fly   931 FESNSKTSCLSHEKCSSP-SALKEELKRLKFFELSLKEQIKDLSLQRDGLVMELQQLQEARPVLE 994
            ..|.:.|..:.|...:|. |....:.|.|:..:|.|:::||||:.:||.|:||||||:||:.||.
Mosquito  1319 THSLASTHSIQHSIANSEGSTSGVQTKHLRLMQLQLQDEIKDLTHERDCLMMELQQLKEAKSVLA 1383

  Fly   995 KAYART-THPTLQQRLNQLELRNRHLQNVIKQQQHYTESLMQQSWRQHQVELNDLHSRIETQGVL 1058
            ::||:| :||...|::..||.:|||||.::||||.||||::.|.|:|.:.|:|||.:|:|.|.|:
Mosquito  1384 RSYAKTASHPNQMQKIQNLEQKNRHLQLMVKQQQQYTESILHQIWQQQRSEINDLRNRLEAQCVV 1448

  Fly  1059 LADQTQRLQSADILVKDLYVENSHLTATVQRLEQQRARVNLIHQQQQQQRLVG------GGLPGM 1117
            ::||..||.:.||||||:|.|||.|...|||||.|..|.|.:.|..|.....|      |.:||:
Mosquito  1449 ISDQAARLANNDILVKDMYAENSQLMLQVQRLEHQCNRANWMQQYNQSNSSSGSHHGLSGIMPGL 1513

  Fly  1118 P 1118
            |
Mosquito  1514 P 1514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nin	NP_001260093.1	Smc	<306..>775	CDD:440809	221/568 (39%)
Bsg25D	XP_061516375.1	None