Protein Alignment Nin and ninl

DIOPT Version :10

• Sequence 1: NP_001260093.1
• Gene: Nin / 33757
• FlyBaseID: FBgn0000228
• Length: 1118
• Species: Drosophila melanogaster
• Sequence 2: XP_017949723.2
• Gene: ninl / 100124705
• XenbaseID: XB-GENE-990139
• Length: 1847
• Species: Xenopus tropicalis
• Alignment Length: 1292
• Identity: 269/1292 - (20%)
• Similarity: 498/1292 - (38%)
• Gaps: 310/1292 - (23%)

  Fly     8 YEQKLYQMFRSCETQ-CGLLDEKSLLKLCSLLELRDQGSALIASLGGSHQLG-VSFGQFKEALLN 70
            |..:|..:|.||:|. .|.||:..|..||..|.|..|...|:.:|.|:.... |:|.:|||..:.
 Frog     9 YVSQLLDVFNSCDTTGTGYLDKDELTDLCRKLHLDVQLPLLLQTLLGTDIFARVNFEEFKEGFVA 73

  Fly    71 FLGSEFDGNTSSGFIERSLVITDEPLNNTYIESPPESSDREVSPKLVVGTKKYGRRSRPQQGIYE 135
            .|.|..|.:.|.          ||   ::|:|  |...| ||.||.|.|||:||||::|:.
 Frog    74 VLSSTIDISISE----------DE---SSYLE--PVIPD-EVKPKYVKGTKRYGRRTQPEH---- 118

  Fly   136 LSVTDSDNTDEDQLQQQQNQRSLNGCDELGVQVQRSSS-------QSD-------------LPGS 180
                ::...:.::..|:|:|    |..:...|::||||       :||             ....
 Frog   119 ----EAAENEANKFLQEQHQ----GKGQRKSQLKRSSSLESVESLKSDEEAENGKEPLNENFEAQ 175

  Fly   181 RRLRSVHTSGSKLKRCASLPAR-----------RKMNSNTTGATTSPTAAAKLKQLSIQSQAQHS 234
            .:|||.:......||..|.|..           .::.....|.......|...|.:.::..::
 Frog   176 GQLRSWNPEIFDGKRRNSSPCSDMTEHQVRDIWEELGVGHNGYLNQQELATVCKNIGLKDLSK-- 238

  Fly   235 SSVESLGHRLATN------------------PAPSS----EH---WRCYHGGRWSCCKDTVTPQQ 274
            ..:|.|.::|..:                  |.|.|    :|   |.|:.....| .:.|.||..
 Frog   239 EELEDLFNKLDRDGDGRVSFQEFQEGLFSHAPVPISSTPLKHRRPWACFQPMEDS-SRMTTTPSL 302

  Fly   275 LETI----------------SVHSIMEAWELASIPNTRNLLHVLGFDEEEEVNLQQLTKALEEEL 323
            |...                |...||..||...|.:.:.:|..|.|:..|:|||..||.||:.||
 Frog   303 LSAFGGLHLFSSIDDGTGFGSPEQIMIIWEEEGIEDGKEILTSLDFNLGEQVNLLDLTSALDNEL 367

  Fly   324 RGIDGDHEQSNMLRALAALQA--TELGNYRLAYRQQHEENLKLRADNKAANQRVALLAVEVDERH 386
            ..      ..|.:. ||||.:  .||.:......|...|..|::.|.:.|.:|...||.|||:.:
 Frog   368 IA------TKNRIH-LAALASYKNELYHRHGLVEQVTRERDKIKQDFEKAEKRNLQLASEVDDHN 425

  Fly   387 ASLEDNSKKQVQQLEQRHASMVREITLRMTNDRDHWTSMTG----KLEAQLKSLEQEEIRLRTEL 447
            :.:|..::.:::.||..:...:..:.:::..:::.:...:.    ||||.|.:|:.||..||..|
 Frog   426 SEMEQLNESKIKDLELEYRQRLSVLRIQLEGEKEQFMHQSDQHRTKLEADLANLKMEEASLRERL 490

  Fly   448 ELVRTENTELESEQQKAHIQITELLEQNIKLNQELAQTSSSIGGTPEHSPLRPRRHSEDKEEEML 512
            .|...||:.|:.|       :.|::|:..:...::.:..:::...     |:.:|..:....|..
 Frog   491 NLSVKENSRLQKE-------MVEVVEKLSETENDVLKLQTNVDDL-----LKGKRQVDHPHMEFC 543

  Fly   513 QLMEKLAAL----QMENAQLRDKTDELTIEIESLNVELIRS-------KTKAKKQEKQEKQEDQE 566
            ...|:.|.:    :::..:|||:.|||.|::|:|..:|..|       |.|..|....:.:|...
 Frog   544 SQEERFADIIKEYEIQCRELRDQNDELRIQLETLRSQLSESKYSRLLAKIKDNKLLHLKAKEKIH 608

  Fly   567 SAATATKRRGDSPSKTHLTEESPRLGKQRKCTEGEQSDASNSGDWLALNSELQRSQ--SQDEELT 629
            :.:.:....|.......:.......|.....|...:...||      :.:||.:.|  .|.:|:.
 Frog   609 NNSLSNGSHGKKGLSAKVRRSVSAAGANGPVTMEPELPPSN------IEAELTKQQLKEQQQEIQ 667

  Fly   630 SLR----------QRVAEL-----EEELKAAKEGRSLTPESRSKELETSLEQMQRAYEDCEDYWQ 679
            .|:          :|..||     |:|.||.:....| ..|..:|....||::...|::..|..:
 Frog   668 DLKIELETKVNYYEREVELMKSNFEKERKATEHSFKL-EISELEEQRADLEELNAKYQEVIDGLK 731

  Fly   680 TKLSEERQLFEKERQIYEDEQHESDKKFTELMEKVREYEEQFSKDGRLSPIDERDMLEQQYSELE 744
            |:||:..|.            .|.:|:|.|  ||: |.|:.::|:  ||.:.:|  |..:..:||
 Frog   732 TQLSKSAQC------------QEMEKRFKE--EKL-ELEQYYAKE--LSALGQR--LTAEKDQLE 777

  Fly   745 AEAAQLRSSSIQMLEEKAQE-----ISSLQSEIED-----LRQRLGESVEILTGACELTSESVAQ 799
            .|..:.....:|.:.::|:|     :::.:::..:     |:|...|..|      .|....:|:
 Frog   778 EELRRTHQHELQSMRQEAEEALNETLAASEAQWAEHWQNLLQQHYNEKNE------ALEKHELAK 836

  Fly   800 LSAEAGKSPASSPISYLWLQSTIQE-------PAKSLADSKDE---------------ATASAIE 842
            :|               |.:..::|       ....||..|.|               ....|||
 Frog   837 IS---------------WREEQLREQNLWEERERTLLAQCKKEQLKQEEKHNEEQAHICKTFAIE 886

  Fly   843 LLGGSPSHKTASRNNLTTS------ETSIFSTTPFESSQSGPS----PTNSGNSNAYGANPGPAP 897
                  ..:..||.|:...      |..:...|...:::.|..    ...||.. .||.:.....
 Frog   887 ------KEEIESRYNIKIDQLKREIECLVSRVTTMTTAERGQPLAWVAVQSGEC-LYGNSADKGS 944

  Fly   898 ISKPKRSQSPQQAAASEGEIADCETSSTASGKSFESNSKTSCLSH------EKCSSPSALKE--- 953
            ::|.....|.             |.|......:...|.:.:.:.:      ||.|.....:|
 Frog   945 VNKADMGHSD-------------ELSEMTGQHNVTPNPQCTRVLYRLKDVDEKLSLLKGTEESTE 996

  Fly   954 -ELKRLKFFELSLKEQIKDLSLQRDGLVMELQQLQEARP-------------VLEKAYARTTHPT 1004
             :|.:::....||:.|::|...:.:.|:.:...|:|.:.             :|.:|........
 Frog   997 VKLHKMECVVFSLRAQLQDDMKEIEALLKKQNYLEEEKAQLGSRLEAMEEEHLLSEAKQHQLMVQ 1061

  Fly  1005 LQQRLNQLELRNRHLQNVIKQQQHYTESLMQQSWRQHQVE--LNDLHSRIETQGVLLADQTQRLQ 1067
            ||::.:.::.::..||::.|.::...:.:...:....|:|  ||....:.:.....|::..:.:.
 Frog  1062 LQEKSDFIKEQDSKLQHISKDKEELEKQVAALTGEAVQLEHKLNAFSGKYQEMTACLSETIEGIH 1126

  Fly  1068 SA--------------DILVKDLYVENSHLTATVQRLEQQ----RARVNLIHQQQQQ 1106
            |.              .:.:::|...|..|:..:...|::    :.::|::.::.|:
 Frog  1127 SEQNVCHTPDGIPANDSVFIEELLARNVSLSQQLNDKEEEVCILQRKINIMVRRLQE 1183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nin	NP_001260093.1	Smc	<306..>775	CDD:440809	117/512 (23%)
ninl	XP_017949723.2	EF-hand_7	203..263	CDD:463900	6/61 (10%)
		Smc	<363..>906	CDD:440809	129/614 (21%)
		SMC_prok_B	668..1549	CDD:274008	100/577 (17%)
		Smc	<1368..>1835	CDD:440809