DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	520	Identity:	163/520 - (31%)
Similarity:	261/520 - (50%)	Gaps:	45/520 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLT 66
            |:.|    ||:||.|||...|..||.....|:|:|... .|        |.:..|..:..::|.|
Human    19 WLLL----LLVGASWLLAHVLAWTYAFYDNCRRLRCFP-QP--------PRRNWFWGHQGMVNPT 70

  Fly    67 PANIFSYIRESTAKANGQNY-IWNFLFAPEYNIVRAEDAEEIFQ-STKITTKN-MSYELIRPFLG 128
            ...:  .:.........|.: :|....:|..::...:....:.. |..|..|: ..|..:.|:||
Human    71 EEGM--RVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLG 133

  Fly   129 DGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE----SKKFIKILDKNVGFELELNQIIPQ 189
            ||||:|...||...|:.||||||||||:.::.||.|.    ..|: ::|.......|::.:.|..
Human   134 DGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKW-QLLASEGSACLDMFEHISL 197

  Fly   190 FTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRILRT 254
            .||:::.:...........:.:||..||.:...:.::|....|:..::.::|..|.:::.|..|.
Human   198 MTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRL 262

  Fly   255 IHGFSSGIIQRKRQQFKQKQLGQVDEF----GKKQRYAMLDTLLAAEAEG--KIDHQGICDEVNT 313
            :|.|:..:||.:|:....:   .||:|    .|.:....:|.||.::.|.  |:..:.|..|.:|
Human   263 VHDFTDAVIQERRRTLPSQ---GVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADT 324

  Fly   314 FMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHLECV---IKES 375
            |||.|:|||::.|.:.|..||.|.:.||||.:|:|:|.:| .|....::::|.||..:   :|||
Human   325 FMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKD-REPKEIEWDDLAHLPFLTMCMKES 388

  Fly   376 LRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNR 439
            |||.|..|:|.|...::.|: :|.|:||.....|.::....:...:|.|..:.|.||.|||...|
Human   389 LRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKER 453

  Fly   440 HPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLED-------LTFENGIVLRTQ 497
            .|.||:||||||||||||.|.:.|:||:||..:..|::|| ...|.       |..|.|:.||.:
Human   454 SPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP-DHTEPRRKPELVLRAEGGLWLRVE 517

Fly 498 497
Human 518 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	147/471 (31%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	17/50 (34%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	146/479 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154867
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850