DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	538	Identity:	157/538 - (29%)
Similarity:	248/538 - (46%)	Gaps:	106/538 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIGALWLLLRQLNKTYFILSLCKRVR-TADGSPLESKVFVVP------GKTRF--GNNLDLLN-- 64
            |:..|.|:|.|..|.|.     :|.| ..|.||     |..|      |..:|  .:|::.|:
Mouse    18 LVFCLALVLMQAMKLYL-----RRQRLLRDLSP-----FPGPPAHWLLGHQKFLQEDNMETLDEI 72

  Fly    65 -----------LTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKITTKNM 118
                       :.|...|.||                 :.|:|        .:||.|.  |...|
Mouse    73 VKKHPCAFPCWVGPFQAFFYI-----------------YDPDY--------AKIFLSR--TDPKM 110

  Fly   119 SY--ELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFE- 180
            .|  :|:.|.:|.|||.....:|...|..||||||.:||:..:.......|   .:|||   :|
Mouse   111 QYLHQLLTPCIGRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVK---VMLDK---WEK 169

  Fly   181 --------LELNQIIPQFTLNNICETALGVKLDDMSEG--NEYRKAIHDFEIVFNQRMCNPLMFF 235
                    :|:.:.|...||:.|.:.|.|.:.:....|  ..|.||..:...:.:.|:.|   |:
Mouse   170 MWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQINGTYESYVKATFELGEIISSRLYN---FW 231

  Fly   236 NWYFFLFGDYKK---YSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAE 297
            :.:..:|....|   :..:.:.||.::..|||.:::..|    .||.:...:.....||.:|:|:
Mouse   232 HHHDIIFKLSPKGHCFQELGKVIHQYTEKIIQDRKKILK----NQVKQDDTQTSQIFLDIVLSAQ 292

  Fly   298 AEGKIDHQGICD-----EVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEV 357
            ||   |.:...|     ||||||:.|:|.::.|:.:.|..|||:.:.|:||..|::.:..|...:
Mouse   293 AE---DERAFSDADLRAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSI 354

  Fly   358 SMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEE-SVMNGLVLPKNAQISIHIYDIMRDARHFP 421
            :..|.:|:.:....|||:|||.|..|.|.|...:. ::.:|..||....:.:.|:.:..:...:.
Mouse   355 TWEQLDEMSYTTMCIKETLRLIPPVPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWN 419

  Fly   422 KPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDL 486
            .|..|.|.||..|||..|||.||:|||:||||||||:|.:||:||.:|.::.:|::.|     ||
Mouse   420 DPKVFDPLRFTKENSDQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQVAP-----DL 479

  Fly   487 T----FENGIVLRTQQNI 500
            |    |.:..|||.:..|
Mouse   480 TRPPAFSSHTVLRPKHGI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	144/497 (29%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	144/499 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850