DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac3 and cyp2j20

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_001337781.3	Gene:	cyp2j20 / 797309	ZFINID:	ZDB-GENE-041210-324	Length:	496	Species:	Danio rerio

Alignment Length:	545	Identity:	117/545 - (21%)
Similarity:	206/545 - (37%)	Gaps:	142/545 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLT 66
            ||. :.|.|:...::|||....|.          :|....|        ||........|:.::.
Zfish     9 WID-IKSILIFVCVFLLLSDFIKN----------KTPKNFP--------PGPWSLPIIGDIHHID 54

  Fly    67 PANIFSYIRESTAKANGQNYIWNF-LFAPE------YNIVRAEDAEEIFQSTKITTKNMSYELIR 124
            |:.:...:.|...|   ...|::. ||.|.      ||:|:....:|        ..|::...|.
Zfish    55 PSKLHLQLSEFAEK---YGKIFSLRLFGPRIVVLNGYNLVKEVYTQE--------GDNLADRAIL 108

  Fly   125 P----FLGD-GLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFELELN 184
            |    .:|| ||:.|...||..:|:     |..:.|::| .:.|:..:..|.:   ..||   ||
Zfish   109 PLFHDIIGDKGLVASSGYKWKQQRR-----FALSTLRNF-GLGKKNLEPSINL---ESGF---LN 161

  Fly   185 QII---------PQFTLNN-----ICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFF 235
            :.|         |:..|||     ||....         ||.:..:.|.|:.:        |...
Zfish   162 EAISNEQGQPFDPRLLLNNAVSNVICALVF---------GNRFDYSDHKFQTL--------LKNI 209

  Fly   236 NWYFFLFGD-----YKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEF-GKKQRYAMLDTLL 294
            |....|.|.     |.....::|.:.|....||         ...|::.|| |:|..
Zfish   210 NETVHLEGGICAQLYNMLPWLMRLLPGPHKRII---------ALWGKLIEFVGEKVN-------- 257

  Fly   295 AAEAEGKIDHQGI--CDEVNTFM---------------------------FGGYDTTSTSLIFTL 330
                |.|:||..:  .|.::.|:                           ..|.:||||:|.:.|
Zfish   258 ----EHKVDHDPLNPRDYIDCFLDEMEKHKDDTAAGFDVENLCICTLDLFVAGTETTSTTLYWGL 318

  Fly   331 LLLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHLECVIKESLRLFPSAPI-IGRTCIEESV 394
            |.:..:.::|.:..:|:..:.....:.|:...:.:.:...||.|..|:....|| :.||..|::.
Zfish   319 LYMMKYPEIQAKVQQEIDVIVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIIPINLARTTSEDTQ 383

  Fly   395 MNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKF 459
            :....:||...::.::..::.|...:..|:.|.|..||......|...||:|||.|.|.|:|::.
Zfish   384 IEKYSIPKGTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSLGKRVCLGEQL 448

  Fly   460 GVLEIKVLLAAVIRNFKLLPATQLE 484
            ..:|:.:..:::::.|...|...:|
Zfish   449 ARMELFLFFSSLLQRFTFSPPAGVE 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	107/496 (22%)
cyp2j20	XP_001337781.3	p450	38..492	CDD:278495	108/505 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010