DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	532	Identity:	157/532 - (29%)
Similarity:	257/532 - (48%)	Gaps:	61/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLT 66
            |:.|    ||.||..||...|...|.:.....|:|.....|..:.:.         .:|.|:..:
Mouse    19 WLLL----LLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWIL---------GHLGLIQSS 70

  Fly    67 PANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKI-----------TTKNMSY 120
            ...:. || :|..:.......|  ...|.:.::|      ||....|           ....:.|
Mouse    71 EEGLL-YI-QSLVRTFRDACCW--WVGPLHPVIR------IFHPAFIKPVVLAPALVAPKDTVFY 125

  Fly   121 ELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESK----KFIKILDKNVGFEL 181
            ..::|:||||||:|...||...|:.||||||||||:.::.:|.:.:.    |:.::..|...: |
Mouse   126 RFLKPWLGDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMHAKWQRLASKGSAY-L 189

  Fly   182 ELNQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYK 246
            .:.:.|...||:::.:.......:...:.:||..||.:...:..:|....|:..:.:::|..|..
Mouse   190 NMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGM 254

  Fly   247 KYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLD----TLLAAEAEGK-IDHQG 306
            ::.:..|.:|.|:..:|:.:|:....:  |.||....|.:...||    .||:.:..|| :..:.
Mouse   255 RFRKACRLVHDFTDAVIRERRRTLLDQ--GGVDVLKAKAKAKTLDFIDVLLLSKDEHGKALSDED 317

  Fly   307 ICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDL-----PEDI--DEVSMFQFNE 364
            |..|.:||||||:|||::.|.:.|..||.|.:.||||.:|:::|     ||:|  |:::...|
Mouse   318 IRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPF-- 380

  Fly   365 LIHLECVIKESLRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLP 428
               |...|||||||.|....|.|.|.::.|: :|.|:||.....|.|:....:...:|.|..:.|
Mouse   381 ---LTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVWPDPEVYDP 442

  Fly   429 ERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIV 493
            .||..:|...|.|.||:||||||||||||.|.:.|:||.||..:..|::||..  ::...:..::
Mouse   443 FRFDADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDD--KEPRRKPELI 505

  Fly   494 LRTQQNIKVKFE 505
            ||.:..:.:|.|
Mouse   506 LRAEGGLWLKVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	142/480 (30%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	143/492 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845344
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850