DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	529	Identity:	167/529 - (31%)
Similarity:	262/529 - (49%)	Gaps:	74/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLIG-ALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLTPANIFSY 73
            ||:| |.|:|.|.|..||.....|.|: :....|        |.|..|..:|.::......: ..
Mouse    22 LLLGVASWILARILAWTYSFYENCSRL-SCFPQP--------PKKNWFSGHLGMIQSNEEGM-QL 76

  Fly    74 IRESTAKANGQNY--IWNFLFAPEYNIVRAED----AEEIFQSTKITTKNMSY-ELIRPFLGDGL 131
            :.|.     ||.:  :..|...|...::|..|    |..:.....:..|:|:: ..::|:|||||
Mouse    77 VTEM-----GQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGL 136

  Fly   132 LISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILD---KNVGFE----LELNQIIPQ 189
            .:|...||...|:.|||||||:||:.::.||.:.    :.|:.   |::..|    ||:.:.|..
Mouse   137 FLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQS----VNIMHAKWKHLSSEGSARLEMFEHISL 197

  Fly   190 FTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRILRT 254
            .||:::.:...|...:.....:||..||.:...:..:|.....:|.::.::...|.:::.:....
Mouse   198 MTLDSLQKCLFGFDSNCQESPSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDL 262

  Fly   255 IHGFSSGIIQRKRQQFKQKQLGQVDEFGK-KQRYAMLD----TLLAAEAEGK-IDHQGICDEVNT 313
            :|.|:..:|:.:|.....:   ..|||.| |.:...||    .|||.:..|| :..:.|..|.:|
Mouse   263 VHNFTDAVIRERRHTLSSQ---NHDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADT 324

  Fly   314 FMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDL-----PEDI--DEVSMFQFNELIHLECV 371
            |||||:|||:::|.:.|..||.|.:.||||.:|:|:|     ||:|  |:::...|     |...
Mouse   325 FMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEWDDLAQLPF-----LTMC 384

  Fly   372 IKESLRLFPSAPIIG--RTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLP 433
            |||||||  .:|:|.  |.|..:.|: :|.|:||.....|.|:.|..:...:|.|..:.|.||.|
Mouse   385 IKESLRL--HSPVIDLLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDP 447

  Fly   434 ENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLED----------LTF 488
            ||...|.|.||:||||||||||||.|.:.|:||.||..:..|::||    :|          |..
Mouse   448 ENPQKRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILP----DDKEPRRKPEIILRA 508

  Fly   489 ENGIVLRTQ 497
            |.|:.||.:
Mouse   509 EGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	154/487 (32%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	153/493 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845305
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850