DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac3 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	161/543 - (29%)
Similarity:	262/543 - (48%)	Gaps:	73/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIAL----LGS-------SLLIGAL-WLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKT 54
            |:.:    |||       .||:||. |:|.|.|..||.....|.|:|....|         |.:.
  Rat     3 WLTVSGLDLGSVVTSTWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQS---------PKRN 58

  Fly    55 RFGNNLDLLNLTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQS-TKITTKNM 118
            .|..:|.::......: ..:.|........:.||....:|...:|.......:.|: ..:..|:.
  Rat    59 WFLGHLGVIQSNEEGM-QLVTEMGQTFRDVHLIWLGPVSPVLRLVDPAFVAPLLQAPALVAPKDP 122

  Fly   119 SY-ELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILD---KNVGF 179
            :: ..::|:|||||.:|...||...|:.|||||||:||:.::..|.:.    :.|:.   |::..
  Rat   123 TFLHFLKPWLGDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKTFNQS----VNIMHAKWKHLCL 183

  Fly   180 E----LELNQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFF 240
            |    ||:.:.|...||:::.:...|...:.....:||..|..:...:..:|.....::.::.::
  Rat   184 EGSARLEMFENISLMTLDSLQKCLFGFDSNCQESPSEYISATLELSSLTRKRSYKLFLYLDFLYY 248

  Fly   241 LFGDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEF------GKKQRYAMLDTLLAAEAE 299
            ...|.:::.:....:|.|:..:|:.:|:....:   .||||      .|.:....:|.||.|:.|
  Rat   249 RTADGQRFRKACDLVHSFTDAVIRERRRLLSSQ---GVDEFLESKTKSKSKTLDFIDVLLLAKDE 310

  Fly   300 -GK-IDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDL-----PEDI--D 355
             || :..:.|..|.:||||||:|||:::|.:.|..||.|.:.||||.:|:.:|     ||:|  |
  Rat   311 HGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLASHPEYQERCRQEVWELLRDREPEEIEWD 375

  Fly   356 EVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARH 419
            :::...|     |...|||||||.|.|..:.|.|.::.|: :|.|:||.....|.|:.|..:...
  Rat   376 DLAQLPF-----LTMCIKESLRLHPPAVDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSV 435

  Fly   420 FPKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLE 484
            :|.|..:.|.||.|||...|.|.:|:||||||||||||.|.:.|:||.:...:..|:.||    :
  Rat   436 WPDPEVYDPFRFDPENRQKRSPLSFIPFSAGPRNCIGQTFAMNEVKVAVGLTLLRFRFLP----D 496

  Fly   485 D----------LTFENGIVLRTQ 497
            |          |..|.|:.||.:
  Rat   497 DKEPRRKPELILRAEGGLWLRVE 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	143/482 (30%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	138/459 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850