Protein Alignment Cyp4ac3 and CYP4F12

DIOPT Version :9

• Sequence 1: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 170/520 - (32%)
• Similarity: 272/520 - (52%)
• Gaps: 45/520 - (8%)

  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTR-FGNNLDLLNL 65
            |:.||   |::|: |||.|.|..||...:.|:|:          :.|..|.|.. |..:|.|:..
Human    19 WLLLL---LVVGS-WLLARILAWTYAFYNNCRRL----------QCFPQPPKRNWFWGHLGLITP 69

  Fly    66 TPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQ-STKITTK-NMSYELIRPFLG 128
            |...:.:..:.|...:.|.. :|.....|...:...:....|.. |..|..| |:....::|:||
Human    70 TEEGLKNSTQMSATYSQGFT-VWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLG 133

  Fly   129 DGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDK--NVGFE----LELNQII 187
            :|:|:|...||...|:.||||||||||:|:::||.:.:.   .:|||  ::..|    |::.:.|
Human   134 EGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSAN---IMLDKWQHLASEGSSRLDMFEHI 195

  Fly   188 PQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRIL 252
            ...||:::.:.............:||...|.:...:..:|..:.|...::.::|..|.:::.|..
Human   196 SLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRAC 260

  Fly   253 RTIHGFSSGIIQRKRQQFKQKQLGQVDEFGK-KQRYAMLD----TLLAAEAEGK-IDHQGICDEV 311
            |.:|.|:..:|:.:|:....:   .:|:|.| |.:...||    .||:.:.:|| :..:.|..|.
Human   261 RLVHDFTDAVIRERRRTLPTQ---GIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEA 322

  Fly   312 NTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID--EVSMFQFNELIHLECVIKE 374
            :||||||:|||::.|.:.|..||.|.:.||||.:|:|:|.:|.|  |:......:|..|...:||
Human   323 DTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKE 387

  Fly   375 SLRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVN 438
            ||||.|.||.|.|.|.::.|: :|.|:||.....|.|..:..:...:|.|..:.|.||.||||..
Human   388 SLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKG 452

  Fly   439 RHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLL-----PATQLE-DLTFENGIVLRTQ 497
            |.|.||:||||||||||||.|.:.|:||:||.::.:|:.|     |..:|| .:..|.|:.||.:
Human   453 RSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517

  Fly   498  497
            Human   518  517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	155/471 (33%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	151/460 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154891
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850