DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac3 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	401	Identity:	102/401 - (25%)
Similarity:	187/401 - (46%)	Gaps:	35/401 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 FLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNV--GFELELNQIIP 188
            ||...|..:.|::|...|..|:|||.....:..:.|..:.....::.|.:..  ...:.|.....
Human   113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFG 177

  Fly   189 QFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRILR 253
            .:|::.|..|..||.||.::...:        ..:.|.:....|.|.:.:..|...:...:.:..
Human   178 AYTMDVITGTLFGVNLDSLNNPQD--------PFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFE 234

  Fly   254 TI----------HGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEGKIDHQGIC 308
            .:          |...:.|.:.|..:.|.||..:||.|.:     |:|:..:.|.:   .|:.:.
Human   235 ALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQ-----MIDSQNSKETK---SHKALS 291

  Fly   309 D-----EVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHL 368
            |     :....:|..||||||:|.|.:..||.|.|||::..||:..:..:...|:.....::.:|
Human   292 DLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYL 356

  Fly   369 ECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPE-RFL 432
            :.|:.|:|||||....:.|.|.::..:||:.:||...:.:.||.:..|.:::.:|.:|.|| ||.
Human   357 DMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421

  Fly   433 PENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLE-DLTFENGIVLRT 496
            .:|..:...:.::||.||||||||.:|.:..||:.:...::||...|..:.: .|..:|..:|:.
Human   422 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQP 486

  Fly   497 QQNIKVKFEAR 507
            ::.|.:|...|
Human   487 EKPIVLKVHLR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	100/396 (25%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	100/396 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910