DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	529	Identity:	159/529 - (30%)
Similarity:	252/529 - (47%)	Gaps:	52/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIAL--LGSS-----LLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNN 59
            |:.|  :.:|     .|:|..|.|.|.|.:.|.:.:.|:|:   .|.|..      |.|..|..:
Mouse    35 WLGLGPMSASPWLLFFLVGISWFLARFLTQLYTLYAKCQRL---CGFPQP------PKKNWFWGH 90

  Fly    60 LDLLNLTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQ-STKITTK-NMSYEL 122
            |.:...|...:.......|....| ...|.....|...:...:....:.. |..:..| ::.|..
Mouse    91 LGMSPPTEEGMKQVTELVTTYPQG-FMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDDIFYSF 154

  Fly   123 IRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESK----KFIKILDKNVGFELEL 183
            ::|:||||||:|...||:..|:.||||||||||:.::.||.:.:.    |::::..   |....|
Mouse   155 LKPWLGDGLLVSAGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLAS---GGSTRL 216

  Fly   184 NQI--IPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYK 246
            |..  |...||:.:.:.......:...:.::|..||.:...:..:|....||..:..:.|..|..
Mouse   217 NMFENISLMTLDTLQKCVFSFNSNCQEKPSQYIAAILELSTLAVKRNEQLLMHVDLLYRLTPDGM 281

  Fly   247 KYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLD----TLLAAEAEGK-IDHQG 306
            ::.:..|.:|.|:..:||.:|:...:.  |..|....|.:...||    .||..:.:|| :..:.
Mouse   282 RFYKACRLVHDFTDAVIQERRRTLLKH--GGDDIIKAKAKSKTLDFIDVLLLTKDEDGKELSDED 344

  Fly   307 ICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID--EVSMFQFNELIHLE 369
            |..|.:||||.|:|||::.|.:.|..||.|.:.||||.:|:|:|..|.|  |:......:|..|.
Mouse   345 IRAEADTFMFRGHDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEWDDLAQLPFLT 409

  Fly   370 CVIKESLRLFPSAPIIGRTCIEE-SVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLP 433
            ..|||||||.|...::.|.|.:: |:.:|.::||.....|:|:....:...:..|..:.|.||.|
Mouse   410 MCIKESLRLHPPVTMVSRCCTQDISLPDGRIIPKGVICIINIFGTHHNPTVWRDPEVYDPFRFDP 474

  Fly   434 ENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLED----------LTF 488
            ||...|.|.:|:||||||||||||.|.:.|:||.||..:..|::||    :|          |..
Mouse   475 ENIQARSPLSFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILP----DDKEPRRKPELILRA 535

  Fly   489 ENGIVLRTQ 497
            |.|:.||.:
Mouse   536 EGGLWLRVE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	145/473 (31%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	144/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850