DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	525	Identity:	167/525 - (31%)
Similarity:	263/525 - (50%)	Gaps:	55/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLES-----KVFVVPGKTRFGNNLD 61
            |:.|    ||:|..|||.|.|..||.....|:|::.....|.::     :..|.|.:........
Human    19 WLLL----LLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQ 79

  Fly    62 LLNLTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKITTKNM-SYELIRP 125
            |:...|.....::        |..:....|..|:  |:|...:    .|..:..|:| .|..::|
Human    80 LVTTYPQGFKLWL--------GPTFPLLILCHPD--IIRPITS----ASAAVAPKDMIFYGFLKP 130

  Fly   126 FLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKIL-DK------NVGFELEL 183
            :||||||:|...||...|:.||||||||||:.::.||    .|.:.|: ||      .....|::
Human   131 WLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIF----NKSVNIMHDKWQRLASEGSARLDM 191

  Fly   184 NQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKY 248
            .:.|...||:::.:.....:.:...:.:||..||.:......:|....|:..::.::|..|.:::
Human   192 FEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRF 256

  Fly   249 SRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGK-KQRYAMLD----TLLAAEAEGK-IDHQGI 307
            .|....:|.|:..:||.:|.....:   .:|:|.| |.:...||    .||:.:.:|| :..:.|
Human   257 RRACHLVHDFTDAVIQERRCTLPTQ---GIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDI 318

  Fly   308 CDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID--EVSMFQFNELIHLEC 370
            ..|.:||||.|:|||::.|.:.|..||.|.:.||:|.:|:|:|.:|.:  |:......:|..|..
Human   319 RAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTM 383

  Fly   371 VIKESLRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPE 434
            .|||||||.|..|:|.|.|.::.|: :|.|:||.....|:|..|..:...:|.|..:.|.||..|
Human   384 CIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQE 448

  Fly   435 NSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLED-------LTFENGI 492
            |...|.|.||:||||||||||||.|.:.|:||:||..:.:|::|| |..|.       |..|.|:
Human   449 NIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP-THTEPRRKPELILRAEGGL 512

  Fly   493 VLRTQ 497
            .||.:
Human   513 WLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	151/471 (32%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	148/475 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850