DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	529	Identity:	180/529 - (34%)
Similarity:	286/529 - (54%)	Gaps:	51/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLE------SKVFVVPGKTR----FGNN 59
            :||  :|..|:.|||  |..|.:             :||:      :::..:||...    .||.
Zfish     9 ILG--ILFTAVLLLL--LASTAY-------------NPLKNYIGKWNEMRPIPGMAGAYPIIGNA 56

  Fly    60 LDLLNLTPANIFSYIRESTAKANGQNY-----IW----NFLFAPEYNIVRAEDAEEIFQSTKITT 115
            |. ......:.|:.|.|.|   |...:     :|    .||.     :..||:.|.:..:::...
Zfish    57 LQ-FKTNAGDFFNQIIEGT---NENRHLPLAKVWVGPVPFLI-----LYHAENIEVVLSNSRHLD 112

  Fly   116 KNMSYELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDK-NVGF 179
            |:.||..:.|:||.|||.|..:||..|||.|||.|||:||..||.:..|::...|:.:.| ..|.
Zfish   113 KSYSYRFLHPWLGTGLLTSTGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGE 177

  Fly   180 ELELNQIIPQFTLNNICETALGVKLDDMSEG-NEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFG 243
            .......|....|:.|||||:|.|:...|.. :||.::::....:..:|...|.::.:|.:....
Zfish   178 PFNCFNFITLCALDIICETAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLK 242

  Fly   244 DYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEG--KIDHQG 306
            :.|::::.|:.:|.|::.:| |:|.:|...:.....:.|:::|.|.||.||....|.  |:.|:.
Zfish   243 EGKEHAKRLKILHSFTANVI-RERAEFMSSEPDSDSDQGERKRQAFLDMLLKTTYENGQKLSHED 306

  Fly   307 ICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID-EVSMFQFNELIHLEC 370
            |.:||:||||.|:|||:.|:.:.|.|:..|.:||:....|||::....: .|.:....:|.:|||
Zfish   307 IQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVGVEDLKKLRYLEC 371

  Fly   371 VIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPEN 435
            |||||||:|||.|:..|:..|...:||..:||.....|..|.:.||.|:||:|.:|.||||:|||
Zfish   372 VIKESLRIFPSVPLFARSICEACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPEN 436

  Fly   436 SVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQQNI 500
            |..|||:|::||||||||||||:|.::|.||:||.::|:|.:......|:|.....::||.::.|
Zfish   437 SKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGELILRPEKGI 501

  Fly   501 KVKFEARVK 509
            .:|.:.|.|
Zfish   502 WIKLQRRSK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	166/470 (35%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	166/470 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589858
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950