DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac3 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	526	Identity:	146/526 - (27%)
Similarity:	255/526 - (48%)	Gaps:	79/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIGALWLLLRQ----LNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNL---DLLNLT-- 66
            |:|.|.|||:.    |::.:.|.||    :....:|        |.:..|||.|   ||..:.
Mouse    24 LLGLLLLLLKSAQYYLHRQWLIKSL----QQFPPAP--------PPQWLFGNTLKDQDLQQILLC 76

  Fly    67 ----PANIFSYIRESTAKANGQNYIWN-----FLFAPEYN--IVRAEDAEEIFQSTKITTKNMSY 120
                |:   :|:|          ::|.     .::.|:|.  |:...|.:.:          .||
Mouse    77 VEKFPS---TYVR----------WLWGNHARVVIYDPDYMKVILGRSDPKVV----------RSY 118

  Fly   121 ELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE----SKKFIKILDKNVGFEL 181
            ....|::|.|||:...:||...|:.||||||::||:.::.|..:.    ..|:.:::|::.  .|
Mouse   119 SFFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVMLDKWEQLVDQDC--PL 181

  Fly   182 ELNQIIPQFTLNNICETAL----GVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLF 242
            |:.|.|...|:..:.:.|.    .|:|:|......|.||:.|...:...|:.|.....|..:.|.
Mouse   182 EIYQDISLMTMETMMKCAFSYQGSVQLEDCRNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLS 246

  Fly   243 GDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAE-GK-IDHQ 305
            .:.:.:....:..|..:..:|:.::.|.:.:  .::::|.||:|...||.||.|:.| || :..:
Mouse   247 SNGRSFYHACQIAHKHTERVIRMRKAQLQNE--AELEKFRKKKRLDFLDILLFAQTEDGKSLSDE 309

  Fly   306 GICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHLEC 370
            .:..|::||||.|::||::.:.:....||.|.:.|:||.||::.:..:...|::...:::.:...
Mouse   310 DVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVTLNHLDQMPYTTM 374

  Fly   371 VIKESLRLFPSAPIIGRTCIEE-SVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPE 434
            .|||:|||:|..|...|..... :..:|..|||...:::..|.:..:.|..|....|.|.||.|
Mouse   375 CIKEALRLYPPIPGASRELSSPVTFPDGCSLPKGFLVTLSFYGLHHNPRLRPNAEVFDPSRFAP- 438

  Fly   435 NSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLP-ATQLEDLT------FENGI 492
             ...|...||:|||||.|||||::|.:.|:||.:|..:..|:||| .|::..|.      .:|||
Mouse   439 -GAPRQTHAFLPFSAGTRNCIGKQFTMNELKVAVALTLLRFELLPDPTRVPILVSKIVLKSKNGI 502

  Fly   493 VLRTQQ 498
            .|.|::
Mouse   503 YLHTKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	135/482 (28%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	132/473 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850