DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	137/531 - (25%)
Similarity:	238/531 - (44%)	Gaps:	80/531 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLIGAL-WL-LLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLTPANIFS 72
            |.:||| |: .|....:.||::                  ..:||..    .|.:|..:..||.:
  Fly     8 LAVGALFWIYFLWSRRRLYFLM------------------LKIPGPI----GLPILGSSLENIIT 50

  Fly    73 YIRESTAKANGQN------YIW----NFLFAPEYNIVRAEDAEEIFQSTKITTKNMS-YELIRPF 126
            |.|:.:.:....|      ..|    .|:...:..:|     |:||.|.....|:.. ...|...
  Fly    51 YKRKLSFRTKYLNKYGSTILTWMGPVPFIVTRDPKVV-----EDIFSSPDCHNKSQHIVNAITSC 110

  Fly   127 LGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVG-FELELNQIIPQF 190
            :|:|||...|..|..|||...|:|..::|.||..||..|:|..:.:||..|. .|:::...:.::
  Fly   111 MGNGLLGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRW 175

  Fly   191 TLNNICETALG--VKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRILR 253
            :.....:|.:|  ||.|:..:..   ..:..||.:.:....|.||..           ..:|::.
  Fly   176 SFKIAAQTTMGSEVKHDEHFKNG---SLVESFESLISHSTLNILMPL-----------VQNRMIS 226

  Fly   254 TIHGFSSGIIQRKRQQFK--QKQLGQVDEFGKK-----------QRYAMLDTLLAAEAEGKIDHQ 305
            .|.|:.    :.:...|.  ||.|..|  ..||           :...:::..:....:|.|.:.
  Fly   227 KICGYD----KLRADNFSRIQKMLDNV--VNKKVNPLPKTDSDPESNIVINRAMELYRKGDITYM 285

  Fly   306 GICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDE--VSMFQFNELIHL 368
            .:..|....:..||||::.::...|.|||.|.:.||..:|||..:..|...  ::.....:|.:|
  Fly   286 DVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYL 350

  Fly   369 ECVIKESLRLFPSAPIIGR-TCIEESVMNGLVLPKNAQISIHIYDIMRDARHF-PKPNQFLPERF 431
            |.||||:|||.|:.||..| |..:..:.||:::||...|.|.::...|:...: |..:.|.|:.|
  Fly   351 ERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNF 415

  Fly   432 LPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRT 496
            |.||...:||:|::||:.|.|||||.|:.::..|..|..::||:|:..:|..:||.:.:.:.::.
  Fly   416 LAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDNMTMKL 480

  Fly   497 QQNIKVKFEAR 507
            .:..::|.:.|
  Fly   481 AEYPRLKLQRR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	127/483 (26%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	124/458 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	4	3.960