Protein Alignment Cyp4ac3 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 169/528 - (32%)
• Similarity: 261/528 - (49%)
• Gaps: 61/528 - (11%)

  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTR-FGNNLDLLNL 65
            |:.|    ||:||.|||.|.|..||.....|.|:|          .|..|.|.. |..:|.|::.
Human    19 WLLL----LLVGASWLLARILAWTYTFYDNCCRLR----------CFPQPPKRNWFLGHLGLIHS 69

  Fly    66 TPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKI-----------TTKNMS 119
            :...:.  ..:|.|...|....|  ...|.:.|||      ||..|.|           ....:.
Human    70 SEEGLL--YTQSLACTFGDMCCW--WVGPWHAIVR------IFHPTYIKPVLFAPAAIVPKDKVF 124

  Fly   120 YELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE----SKKFIKILDKNVGFE 180
            |..::|:||||||:|..:||...|:.||||||||||:.::.||.|.    ..|: ::|.......
Human   125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKW-QLLASEGSAR 188

  Fly   181 LELNQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDY 245
            |::.:.|...||:::.:...........:.:||..||.:...:..:|....|::.::.::|..|.
Human   189 LDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDG 253

  Fly   246 KKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEF----GKKQRYAMLDTLLAAEAEG--KIDH 304
            :::.|..|.:|.|:..:||.:|:....:   .||:|    .|.:....:|.||.::.|.  |:..
Human   254 QRFRRACRLVHDFTDAVIQERRRTLPSQ---GVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSD 315

  Fly   305 QGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID--EVSMFQFNELIH 367
            :.|..|.:||||.|:|||::.|.:.|..||.|.:.||||.:|:|:|.:|.:  |:......:|..
Human   316 EDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPF 380

  Fly   368 LECVIKESLRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERF 431
            |...|||||||.|..|.:.|.|.::.|: :|.|:||.....|.::....:...:|.|..:.|.||
Human   381 LTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 445

  Fly   432 LPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLP-------ATQLEDLTFE 489
            .|:|...|.|.||:||||||||||||.|.:.|:||:|...:..|::||       ..:|. |..|
Human   446 DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELV-LRAE 509

  Fly   490 NGIVLRTQ 497
            .|:.||.:
Human   510 GGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	CYP4	87..502	CDD:410721	144/442 (33%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	145/455 (32%)