DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	170/521 - (32%)
Similarity:	276/521 - (52%)	Gaps:	50/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLIGALWLL-LRQLNKTYFILSLCKRVRTADGSPLESKVFVVPG---KTRFGNNLDLLNLTPANI 70
            ||.||.|:: |.|.::                   ..||..:||   ....|....:|.|.|...
  Fly     9 LLFGAGWIIHLGQADR-------------------RRKVANLPGPICPPLIGAMQLMLRLNPKTF 54

  Fly    71 FSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDA---EEIFQSTKITTKNMSYELIRPFLGDGLL 132
            ....||...|......:|.|    ...::.:.||   |::..|.:...|:..|:::..:||:|||
  Fly    55 IKVGREYVLKFGHLQRVWIF----NRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLL 115

  Fly   133 ISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFI-KILDKNVGFELELNQIIPQFTLNNIC 196
            :|..:.||.|||.:||.|||:||:.|:.:|.::|...: ::..|..|...::.:.|....|:.|.
  Fly   116 LSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIA 180

  Fly   197 ETALGVKL-DDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKY--SRILRTIHGF 258
            |||:|.|: ...:|...|.:|:::...:.:.|..:..:.....|.|...:.|:  ::::||:..|
  Fly   181 ETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEF 245

  Fly   259 SSGIIQRKRQQFKQKQLGQVD----EFGKKQRYAMLDTLLAAEAEGK-IDHQGICDEVNTFMFGG 318
            :..:|:::||..:.:|...:|    :.|.|:|.|:||.||.:..:|: :.:..|.:||:||||.|
  Fly   246 TIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEG 310

  Fly   319 YDTTSTSLIFTLLLLALHADVQERCYEEL-QDLPEDIDE-VSMFQFNELIHLECVIKESLRLFPS 381
            :|||:::|.|.|..|:.|.:||.:..||: |.|..|... ||:....||.::|||||||||::|.
  Fly   311 HDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPP 375

  Fly   382 APIIGRTC-----IEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHP 441
            .||:||..     ...||....|:|..::|.|.|:.:.|....||.|::|:|||.  ||.....|
  Fly   376 VPIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--ENGSRVAP 438

  Fly   442 FAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQQNIKVKFEA 506
            |..:||||||||||||||..||:|::||.::|.::|||..|..:...  .||||::...::....
  Fly   439 FKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIV--NIVLRSETGFQLGMRK 501

  Fly   507 R 507
            |
  Fly   502 R 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	160/474 (34%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	151/438 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460520
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000