DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4p2

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	205/519 - (39%)
Similarity:	330/519 - (63%)	Gaps:	19/519 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIALLGSSLLIGALWLLLRQLNKTYFILS-LCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLN 64
            :||::   ::|:...|:.  ::||.|.||: ..:||:|.||.||:|.|.::.|:|.|.|..|||.
  Fly     6 LWISV---AILVVIHWIY--KVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLG 65

  Fly    65 LTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKITTKNMSYELIRPFLGD 129
            .....:|:::|: .||.:|.:|:...:....:|::.|.:|..|.....:.||.:.|..:.|||..
  Fly    66 KDTDQVFTHLRQ-LAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLITKGVIYNFLHPFLRT 129

  Fly   130 GLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFELELNQIIPQFTLNN 194
            |:|.:.::||||||..||..||.:||..|..||..||.||:..........:.|...|.:||||:
  Fly   130 GVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQNEVVVSLKDRISRFTLNS 194

  Fly   195 ICETALGVKLDDMSE-GNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRILRTIHGF 258
            |||||:|:|||:|:| |:.||...|..:....:|:.|||.:.:..:.:|..: ||:..|:.:|.|
  Fly   195 ICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNMFTGH-KYNAALKVVHEF 258

  Fly   259 SSGIIQRKR----QQFKQKQLGQVDEFG----KKQRYAMLDTLLAAEAEGKIDHQGICDEVNTFM 315
            |..||.::|    ::.:.::..|..:..    :|:|:||||||:.||.:|.||..||.:||:|.|
  Fly   259 SREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKDGLIDDIGISEEVDTLM 323

  Fly   316 FGGYDTTSTSLIFTLLLLALHADVQERCYEELQD-LPEDIDEVSMFQFNELIHLECVIKESLRLF 379
            ..||||||..|:|.|:.::|:|..||.||:|:|: :.:|:..:::.|.::|.:|...|||::||:
  Fly   324 AEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQLSKLNYLGYFIKETMRLY 388

  Fly   380 PSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHPFA 443
            ||.||:||..::|:.: |||:|||.:||:||::||.|:.:::..|.:|.||||||:|.:.|||:|
  Fly   389 PSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYA 453

  Fly   444 FVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQQNIKVKFEAR 507
            ::|||||.|||||||:.:.|:|.|:..::::||:||....:.:.|:.||.||.:..||||...|
  Fly   454 YIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQVGITLRFKNKIKVKLVRR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	185/463 (40%)
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	180/452 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472677
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3BNNU
Homologene	1	1.000	-	-		H119658
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm9584
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.900