DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	156/519 - (30%)
Similarity:	253/519 - (48%)	Gaps:	56/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRF---GNNLDL 62
            :|..|    |:...:|:|:|:    :.:|.|        ||.|       ||...|   ||...:
  Fly     3 LWPLL----LITLTIWILVRK----WTLLRL--------GSSL-------PGPWAFPLLGNAQMV 44

  Fly    63 LNLTPANIFSYIRESTAKANGQNY-------IWNFLFAPEYNIVRAEDAEEIFQSTKITT--KNM 118
            ..|.|..||....|...:. |..|       :|.||          ..|||..|:....|  |..
  Fly    45 GKLRPEYIFLVFTELRDRF-GATYRLRLGPQLWVFL----------HSAEETRQALHDPTLRKAD 98

  Fly   119 SYELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFELEL 183
            ::..:.|.:|:|||||....|..:|:.|||||...:|:||........::.:..|....|..||:
  Fly    99 TFMQLEPLIGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGATRGAFLEV 163

  Fly   184 NQIIPQFTLNNICETALGVKLDDMS-EGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKK 247
            .:.:....|:.|.:|::|.:||..| :.:...:|.|....:..:||.|||:..:|.|.....::.
  Fly   164 TEPLFACLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRD 228

  Fly   248 YSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEGK-IDHQGICDEV 311
            ....|:.||.....:|:::.::.    |...:..|:  .:.:|||||.|:.||: :..:.|.||:
  Fly   229 LDEQLQVIHSQMESVIEKRAKEL----LDMGEPAGR--AHNLLDTLLLAKFEGQSLSRREIRDEI 287

  Fly   312 NTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHLECVIKESL 376
            |||:|.|.|||:.::.|.|..||...:.|.|..:||||:..| :...:...|.|.:||.:|||.|
  Fly   288 NTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVL 351

  Fly   377 RLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHP 441
            ||:...|..||...:.:.:.|........:.|::|.:..|..::|.|..|.|||:|||:.....|
  Fly   352 RLYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPP 416

  Fly   442 -FAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQQNIKVKF 504
             |:::|||.||..|||:::.:|.:|:|.|.::|.|::..:.:...|..|..:||:.||.|.|.|
  Fly   417 AFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSF 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	144/467 (31%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	144/467 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	7	7.060