DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	521	Identity:	146/521 - (28%)
Similarity:	255/521 - (48%)	Gaps:	42/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SSLLIGALWLLLRQLNKTYFILS----LCKRVRTADGSP-----LESKVFVVPGKTRFGNNLDLL 63
            |:||:..|:...|.|.:.:.:.|    .|:::......|     |......:|.:....|...:|
Mouse    25 SALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMYLPNEKGLQNEKKVL 89

  Fly    64 NLTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIF-QSTKITTKN-MSYELIRPF 126
            :.....|.:               |...|.|...:|..:..:.:. .|..|..|: ..|..::|:
Mouse    90 DTMHHIILA---------------WVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPW 139

  Fly   127 LGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESK----KFIKILDKNVGFELELNQII 187
            ||||||||...||...|:.|||||||:||:.::.||.:.:.    |:.:.|.:......::.:.|
Mouse   140 LGDGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHLAEGSVTSFDMFEHI 204

  Fly   188 PQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRIL 252
            ...||:::.:.......|.....::|..:|.:...:..:|......:.::.::|..|.:::.:..
Mouse   205 SLMTLDSLQKCVFSYNSDCQERMSDYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQAC 269

  Fly   253 RTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLD----TLLAAEAEGK-IDHQGICDEVN 312
            .|:|.|::.:||.:||..:|:   ..:.:.|.::...||    .|||.:.||| :..:.|..|.:
Mouse   270 DTVHNFTTEVIQERRQALRQQ---GAEAWLKAKQGKTLDFIDVLLLAKDEEGKELSDEDIRAEAD 331

  Fly   313 TFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPE--DIDEVSMFQFNELIHLECVIKES 375
            ||||.|:||||:.|.:.|..||.:.:.||:|.||:|::.:  :::|:......:|......||||
Mouse   332 TFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKES 396

  Fly   376 LRLFPSAPIIGRTCIEE-SVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNR 439
            ||.||...:|.|.|.|: .:.:|.|:||.....:.||....:...:|....:.|.||.|:....|
Mouse   397 LRQFPPVTLISRRCTEDIKLPDGRVIPKGIICLVSIYGTHHNPIVWPDSKVYNPYRFDPDTPQQR 461

  Fly   440 HPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQQNIKVKF 504
            .|.|||||||||||||||.|.:.|::|::|..:..|: |...:...:..:..::|||:..:.:..
Mouse   462 SPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFR-LSVDRTHKVRRKPELILRTENGLWLNV 525

  Fly   505 E 505
            |
Mouse   526 E 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	135/466 (29%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	134/473 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844915
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850