DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	159/550 - (28%)
Similarity:	273/550 - (49%)	Gaps:	69/550 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNL 65
            |...|:| :|:..||:...|:.::.|.:::   .:.:....|:..:..|..|.    :|.::|.:
  Fly    27 MLTTLVG-TLVAMALYEYWRRNSREYRMVA---NIPSPPELPILGQAHVAAGL----SNAEILAV 83

  Fly    66 TPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKITTKNMSYELIRPFLGDG 130
            ....:..|  ..|.||...|.:..||..|       .|.|.|....:..||...|...:|:.|||
  Fly    84 GLGYLNKY--GETMKAWLGNVLLVFLTNP-------SDIELILSGHQHLTKAEEYRYFKPWFGDG 139

  Fly   131 LLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFELELNQIIPQFTLNNI 195
            ||||....|...||.:.|.||.:||:||:..|.:.||..:..:....|...:::..:.|.|::.:
  Fly   140 LLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGKSFDVHDYMSQTTVDIL 204

  Fly   196 CETALGVKLDDMSEGN---EYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYK------KYSRI 251
            ..||:|||  .:.|||   ||.:|:.|...:.::|....|      :.|...||      |..|:
  Fly   205 LSTAMGVK--KLPEGNKSFEYAQAVVDMCDIIHKRQVKLL------YRLDSIYKFTKLREKGDRM 261

  Fly   252 LRTIHGFSSGIIQRKRQQFKQK-------------------------QLGQVDE--FGKKQRYAM 289
            :..|.|.:|.:::.:::.|:::                         .|..:||  .|.|:|.|:
  Fly   262 MNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLAL 326

  Fly   290 LDTL--LAAEAEGKIDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPE 352
            ||.:  :|...:.:.:.:.|.|||||.||.|:||||....|.|.::.:|.|:|.:.:.|.:.:..
  Fly   327 LDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFG 391

  Fly   353 D--IDEVSMFQFNELIHLECVIKESLRLFPSAPIIGRTC-IEESVMNG-LVLPKNAQISIHIYDI 413
            |  :.:.:.....|:.:||.||.|:|||:|..|:|.|.. .:..:.:| ..:||...:.:..|.:
  Fly   392 DNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCV 456

  Fly   414 MRDARHFPKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLL 478
            .|....:|.|.:|.|:.||||...|||.::|:|||||||:|:|:|:.:|::||||:.::||: ::
  Fly   457 HRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNY-IV 520

  Fly   479 PATQLE-DLTFENGIVLRTQQNIKVKFEAR 507
            .:|..| |...:..|:|:.:....|..|.|
  Fly   521 HSTDTEADFKLQADIILKLENGFNVSLEKR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	147/495 (30%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	142/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070