DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac3 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	161/524 - (30%)
Similarity:	252/524 - (48%)	Gaps:	53/524 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFIL----SLCKRVRTADGSPLESKVFVVPGKTR-FGNNLD 61
            |:.|    |||||.|||:|.|.:||...    .||.              |..|.|.. |..:|.
  Rat    19 WLLL----LLIGASWLLVRVLTQTYIFYRTYQHLCD--------------FPQPPKWNWFLGHLG 65

  Fly    62 LLNLTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQ-STKITTKN-MSYELIR 124
            ::..|...: ..:.:..|........|.....|...:...:....:.. |..:..|. :.|..::
  Rat    66 MITPTEQGL-KQVTKLVATYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLK 129

  Fly   125 PFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESK-KFIKILDKNVG--FELELNQI 186
            |:||||||:|...||...|:.||||||||||:.::.||.:.:. ...|..|...|  ..|::.:.
  Rat   130 PWLGDGLLLSDGDKWSCHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSARLDMFKN 194

  Fly   187 IPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRI 251
            |...||:::.:.......:...:.:||..||.:...:..:|....|:..:..:.|..:.:::.:.
  Rat   195 ISLMTLDSLQKCVFSFDSNCQEKPSEYISAILELSALVAKRYQQLLLHTDSLYQLTHNGRRFHKA 259

  Fly   252 LRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLD----TLLAAEAEGK-IDHQGICDEV 311
            .:.:|.|:..:||.:|:....:.  :.|....|.|...||    .||..:.:|| :..:.|..|.
  Rat   260 CKLVHNFTDAVIQGRRRALPSQH--EDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEA 322

  Fly   312 NTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID--EVSMFQFNELIHLECVIKE 374
            :||||.|:|||::.|.:.|..||.|.:.||||.:|:::|..|.:  |:......:|..|...|||
  Rat   323 DTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKE 387

  Fly   375 SLRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVN 438
            ||||.|...:|.|.|.::.|: :|.|:||.....|:|:....:...:|.|..:.|.||.|||..:
  Rat   388 SLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKD 452

  Fly   439 RHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLED----------LTFENGIV 493
            |.|.||:||||||||||||.|.:.|:||.||..:..|::||    :|          |..|.|:.
  Rat   453 RSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLP----DDKEPRRKPELILRAEGGLW 513

  Fly   494 LRTQ 497
            ||.:
  Rat   514 LRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	144/471 (31%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	137/447 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850