Protein Alignment Cyp4ac3 and CYP4V2

DIOPT Version :9

• Sequence 1: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 177/546 - (32%)
• Similarity: 291/546 - (53%)
• Gaps: 68/546 - (12%)

  Fly     1 MWIALLGSSLLI-GALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLN 64
            :|:.|:...||: ||...|  .|.....:|||.:||  |..:....::..:|
Human     4 LWLGLVWQKLLLWGAASAL--SLAGASLVLSLLQRV--ASYARKWQQMRPIP------------- 51

  Fly    65 LTPANIFSYIRES-TAKANGQNYIWNFL-FAPEYN----------------IVRAEDAEEIFQST 111
             |.|..:..:..: ..|.:|:.:....: :..||.                :..||:.|.|..|:
Human    52 -TVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSS 115

  Fly   112 KITTKNMSYELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKN 176
            |...|:..|:.:.|:||.|||.|...||.:|||.|||.|||.||:.||.|..|::...:|.|:|:
Human   116 KQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH 180

  Fly   177 VGFELELNQ-------IIPQFTLNNICETALGVKLDDMS-EGNEYRKAIHDFEIVFNQRMCNPLM 233
            :      ||       .|....|:.|||||:|..:...| :.:||.:|::....:..:|:..|.:
Human   181 I------NQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWL 239

  Fly   234 FFNWYFFLFGDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFG----KKQRYAMLDTLL 294
            :.:.::.:|.:..::.:.|:.:|.|::.:|..:..:....:..:.|..|    |.:|.|.||.||
Human   240 WLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 304

  Fly   295 A-AEAEG-KIDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDL------P 351
            : .:.|| ::.|:.|.:||:||||.|:|||:.::.::|.||..:.:||::...||.|:      |
Human   305 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRP 369

  Fly   352 EDIDEVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRD 416
            ..::::     .:|.:|||||||:||||||.|:..|:..|:..:.|..:.|..:..|..|.:.||
Human   370 ATVEDL-----KKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRD 429

  Fly   417 ARHFPKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPAT 481
            .|:||.|.:|.||||.|||:..|||:|:|||||||||||||||.|:|.|.:|:.::|:|.:....
Human   430 PRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQ 494

  Fly   482 QLEDLTFENGIVLRTQQNIKVKFEAR 507
            :.|:|..|..::||....|.:|.:.|
Human   495 KREELGLEGQLILRPSNGIWIKLKRR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	161/490 (33%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	158/472 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950