DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	180/535 - (33%)
Similarity:	288/535 - (53%)	Gaps:	46/535 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIALLGSSLLI----------GALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTR 55
            :|:.|.|..||:          ||..|    ||....::|..::.:.....|..::.:.:.|...
  Rat     4 LWLGLSGQKLLLWGAASAVSVAGATVL----LNILQMLVSYARKWQQMRPIPSVARAYPLVGHAL 64

  Fly    56 FGNNLDLLNLTPAN--IFSYIRESTAKANGQNYIWNFLF-APEYNIVRAEDAEEIFQSTKITTKN 117
            |        :.|.|  .|..|.:.|.:......|..::. .|...:.:||:.|.|..|:|...|:
  Rat    65 F--------MKPNNTEFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKS 121

  Fly   118 MSYELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFELE 182
            ..|:.::|:||.|||.|...||..|||.|||:|||.||:.||.:..|::...:..|:|:|..| .
  Rat   122 FMYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVNQE-A 185

  Fly   183 LNQIIP--QFTLNNICETALGVKLDDMSEG-NEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGD 244
            .|...|  ...|:.|||||:|..:...|.| :||.:.::....:..:||..|..:|:.::.:|.:
  Rat   186 FNCFFPITLCALDIICETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLWYLMFKE 250

  Fly   245 YKKYSRILRTIHGFSSGIIQRKRQQFKQKQ----LGQVDEFGKKQRYAMLDTLLA-AEAEG-KID 303
            .:.:.:.|:::|.|::.:|..:....|.:|    .|:.....|.:|.|.||.||: .:.|| |:.
  Rat   251 GRDHKKGLKSLHTFTNNVIAERVNARKAEQDCIGAGRGPLPSKTKRKAFLDLLLSVTDEEGNKLS 315

  Fly   304 HQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDL------PEDIDEVSMFQF 362
            |:.|.:||:||||.|:|||:.::.::|.||..:.:||.:..:||.|:      |     |::...
  Rat   316 HEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGRSHRP-----VTLEDL 375

  Fly   363 NELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFL 427
            .:|.:|:|||||:||:|||.|:..|:..|:..:.|..:.|..:..|..|.:.||.|:||.|.:|.
  Rat   376 KKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAGYKISKGTEAVIIPYALHRDPRYFPDPEEFQ 440

  Fly   428 PERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGI 492
            ||||.||||..|||:|:|||||||||||||||.|:|.|.:||.::|.|.:....:.|:|.....:
  Rat   441 PERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWIESNQKREELGLAGDL 505

  Fly   493 VLRTQQNIKVKFEAR 507
            :||....|.:|.:.|
  Rat   506 ILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	166/470 (35%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	161/444 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950