DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	139/528 - (26%)
Similarity:	246/528 - (46%)	Gaps:	66/528 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLD-LLNLTP 67
            ::||...:...|.:||.......|.|.....:|.....|..      |....||:.|. |::...
  Rat    14 SILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSP------PSHWFFGHKLSFLVDQEF 72

  Fly    68 ANIFSYIRESTAKANGQNYIWNF-----LFAPEYN--IVRAEDAEEIFQSTKITTKNMSYELIRP 125
            .:|.:.::...:..  ..::|..     ::.|:|.  |:...|.:          .:.||..:.|
  Rat    73 QDILTRVKNFPSAC--PQWLWGSNVRIQVYDPDYMKLILGRSDPK----------SHHSYRFLAP 125

  Fly   126 FLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFE--LELNQIIP 188
            ::|.|||:...|.|...|:.||||||::.|:.::.|..:..:..:...::.||.:  ||:.|.|.
  Rat   126 WIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHIT 190

  Fly   189 QFTLNNICETAL----GVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFF---------NWYFF 240
            ..||:.|.:.|.    .|:||  .:...|.||:.|.         |.|.||         :..:.
  Rat   191 LMTLDTIMKCAFSQEGSVQLD--RKYKSYIKAVEDL---------NNLSFFRIRNIFHQNDIIYS 244

  Fly   241 LFGDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAE--GKID 303
            |..:.:|.....:..|..:..:|:.::.|.:.::  ::.:..:|:|...||.||.|..|  ..:.
  Rat   245 LSSNGRKARSAWQLAHEHTDQVIKSRKAQLQDEE--ELQKVKQKRRLDFLDILLFARIENGSSLS 307

  Fly   304 HQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHL 368
            .:.:..||:||||.|:|||::.:.:....||.:.:.|:.|.:|:|.|..|...::....:::.:.
  Rat   308 DKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITWDDLDKMPYT 372

  Fly   369 ECVIKESLRLFPSAPIIGR-TCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFL 432
            ...|||:||::|....:.| .....:..:|..|||...:.:..|.:..:...:|.|..|.|.||.
  Rat   373 TMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFA 437

  Fly   433 PENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLP-ATQLE------DLTFEN 490
            ||:|  ||..:|:|||.|.|||||::|.:.|:||.:|..:..|:||| .|::.      .|..:|
  Rat   438 PESS--RHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKN 500

  Fly   491 GIVLRTQQ 498
            ||.||.::
  Rat   501 GIYLRLKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	130/481 (27%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	123/459 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850